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Light therapy for improving cognition, activities of daily living, sleep, challenging behaviour, and psychiatric disturbances in dementia

  1. Dorothy Forbes1,*,
  2. Catherine M Blake2,
  3. Emily J Thiessen1,
  4. Shelley Peacock3,
  5. Pamela Hawranik4

Editorial Group: Cochrane Dementia and Cognitive Improvement Group

Published Online: 26 FEB 2014

Assessed as up-to-date: 20 JAN 2014

DOI: 10.1002/14651858.CD003946.pub4


How to Cite

Forbes D, Blake CM, Thiessen EJ, Peacock S, Hawranik P. Light therapy for improving cognition, activities of daily living, sleep, challenging behaviour, and psychiatric disturbances in dementia. Cochrane Database of Systematic Reviews 2014, Issue 2. Art. No.: CD003946. DOI: 10.1002/14651858.CD003946.pub4.

Author Information

  1. 1

    University of Alberta, Faculty of Nursing, Edmonton, Alberta, Canada

  2. 2

    University of Western Ontario, School of Nursing, Health Sciences Addition H022, London, Ontario, Canada

  3. 3

    University of Saskatchewan, Faculty of Nursing, Saskatoon, Saskatoon, Canada

  4. 4

    Athabasca University, Faculty of Graduate Studies and Faculty of Health Disciplines, Athabasca, Alberta, Canada

*Dorothy Forbes, Faculty of Nursing, University of Alberta, level 3, Edmonton Clinic Health Academy, Edmonton, Alberta, T6G1C9, Canada. dorothy.forbes@ualberta.ca.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 26 FEB 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Ancoli-Israel 2003a/b {published data only (unpublished sought but not used)}
  • Ancoli-Israel S, Gehrman P, Martin JL, Shochat T, Marler M, Corey-Bloom J, et al. Increased light exposure consolidates sleep and strengthens circadian rhythms in severe Alzheimer's Disease patients. Behavioural Sleep Medicine 2003;1(1):22-36.
  • Ancoli-Israel S, Martin J, Gehrman P, Shochat T, Corey-Bloom J, Marler M, et al. Effect of light on agitation in institutionalized patients with severe Alzheimer Disease. American Journal of Geriatric Psychiatry 2003;11(2):194-203.
Burns 2009 {published and unpublished data}
Dowling 2007/Dowling 2005 {published data only}
Dowling 2008 {published data only}
Gasio 2003 {published and unpublished data}
  • Gasio PF, Krauchi K, Cajochen C, van Someren E, Amrhein I, Pache M, et al. Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly. Experimental Gerontology 2003;38(1-2):207-16.
Graf 2001 {published data only}
  • Graf A, Wallner C, Schubert V, Willeit M, Wlk W, Fischer P, et al. The effects of light therapy on Mini-Mental State Examination scores in demented patients. Biological Psychiatry 2001;50(9):725-7.
Lyketsos 1999 {published data only}
McCurry 2011 {published data only}
Mishima 1998 {published data only}
  • Mishima K, Hishikawa Y, Okawa M. Randomized, dim light controlled, crossover test of morning bright light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of Alzheimer's type. Chronobiology International 1998;15(6):647-54.
Nowak 2008 {published data only}
  • Nowak L. The effect of timed blue-green light on sleep-wake patterns in women with Alzheimer's disease. Dissertation Abstracts International: Section B: The Sciences and Engineering 2008;69(6-B):1-154.
Riemersma 2008 {published data only}
  • Riemersma-van der Lek RF, Swaab DF, Twisk J, Hol EM, Hoogendijk WJG, Van Someren EJW. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: A randomized controlled trial. JAMA 2008;299(22):2642-55.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Abegg 1993 {published data only}
  • Abegg A, Wettstein A. Phototherapy of behavioral disorders as a sequela of disordered circadian rhythm in dementia in the elderly: Difficulties in practical applications [Lichttherapie von verhaltensstorungen als folge gestorter zirkadianer rhythmen bei dementiellen alterspatienten: Schwierigkeiten der praktisch-klinischen anwendbarkeit]. Schweizer Archiv fur Neorologie und Psychiatrie Band 1993;144(1):63-80.
Ancoli-Israel 1997 {published data only}
  • Ancoli-Israel S, Klauber MR, Williams Jones D, Kripke DF, Martin J, Mason W, et al. Variations in circadian rhythms of activity, sleep, and light exposure related to dementia in nursing-home patients. Sleep 1997;20(1):18-23.
Ancoli-Israel 2002 {published data only}
Barrick 2010 {published data only}
Chong 2013 {published data only}
  • Chong MS, Tan KT, Tay L, Wong YM, Ancoli-Israel S. Bright light therapy as part of a multicomponent management program improves sleep and functional outcomes in delirious older hospitalized adults. Clinical Interventions in Aging 2013;8:565-72.
Colenda 1997 {published data only}
  • Colenda CC, Cohen W, McCall WV, Rosenquist PB. Phototherapy for patients with Alzheimer disease with disturbed sleep patterns: Results of a community-based pilot study. Alzheimer Disease and Associated Disorders 1997;11:175-8.
Connell 2007 {published data only}
  • Connell BR, Sanford JA, Lewis D. Therapeutic effects of an outdoor activity program on nursing home residents with dementia. Journal of Housing for the Elderly 2007;21(3-4):195-209.
Dawson 1999 {published data only}
  • Dawson P. Bright light treatment for people with Alzheimer's disease. Perspectives 1999;23(1):25-6.
Dowling 2005a {published data only}
  • Dowling GA, Hubbard EM, Mastick J, Luxenberg JS, Burr RL, Van Someren EJW. Effect of morning bright light treatment for rest–activity disruption in institutionalized patients with severe Alzheimer’s disease. International Psychogeriatrics 2005;17(2):221-36.
Fetveit 2003 {published data only}
Haffmans 2001 {published data only}
Hickman 2007 {published data only}
Hozumi 1990 {published data only}
  • Hozumi S, Okawa M, Mishima K, Hishikawa Y, Hori H, Takahashi K. Phototherapy for elderly patients with dementia and sleep-wake rhythm disorders-A comparison between morning and evening exposure. The Japanese Journal of Psychiatry and Neurology 1990;44(4):813-4.
Ito 1999 {published data only}
  • Ito T, Yamadera H, Ito R, Endo S. Effects of bright light on cognitive disturbances in Alzheimer-type dementia. Nippon-Ika_Daigaku-Zusshi 1999;66(4):229-38.
Ito 2001 {published data only}
Kobayashi 2001 {published data only}
Koyama 1999 {published data only}
Laborie 2010 {published data only}
  • Laborie S. Effect of bright light and melatonin on cognitive and non-cognitive function. Cahiers de l'Annee Gerontologique 2010;2(3):194-8.
Lovell 1995 {published data only}
McCurry 2005 {published data only}
McCurry 2006 {published data only}
  • McCurry SM, Logsdon RG, Gibbon LE, Vitiello MV, Teri L. Behavioral treatment for sleep disturbances in Alzheimer's Disease: The Nite-AD study. Research and Practice in Alzheimer's Disease 2006;11:341-6.
Mishima 1994 {published data only}
Mishima 2000 {published data only}
  • Mishima K, Okawa M, Hozumi S, Hishikawa Y. Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons. Chronobiology International 2000;17(3):419-32.
NCT01816152 {published data only}
  • NCT01816152. Methodology Issues in a Tailored Light Treatment for Persons With Dementia. ClinicalTrials.gov NCT01816152.
Okawa 1989 {published data only}
  • Okawa M, Mishima K, Shimizu T, Iijima S, Hishikawa Y, Hozumi S, Hori H. Sleep-waking rhythm disorders and their phototherapy in elderly patients with dementia. The Japanese Journal of Psychiatry and Neurology 1989;43(2):293-5.
Okawa 1999a {published data only}
  • Okawa M, Mishima K, Hishikawa Y, Hozumi S, Hori H. Sleep disorder in elderly patients with dementia and trials of new treatments-Enforcement of social interaction and bright light therapy. Unknown 1999;Unknown:128-32.
Okawa 1999b {published data only}
  • Okawa M, Mishima K, Hozumi S. Effects of environmental stimulation with bright light and transcranial electrostimulation on sleep and behavior disorders in elderly patients with dementia. Alzheimer's Disease and Related Disorders 1999;87:757-62.
Okumoto 1998 {published data only}
Porter 2012 {published data only}
  • Porter G, Leonards U, Troscianko T, Haworth J, Bayer A, Tales A. Dealing with illumination in visual scenes: effects of ageing and Alzheimer's disease. PLoS ONE [Electronic Resource] 2012;7(9):e45104.
Rheaume 1998 {published data only}
  • Rheame Y, Manning B, Harper D, Volcier L. Effect of light therapy upon disturbed behaviors in Alzheimer patients. American Journal of Alzheimer's Disease 1998;13(6):291-5.
Riemersma 2001 {published data only}
  • Riemersma R, Van Hutten R, Kalis A, Hoekstra R, Hoogendijk W, Scherder E, Swaab D, Van Someren E. Indirect bright light therapy decreases sleep fragmentation in institutionalized demented elderly. Sleep-Wake Research in the Netherlands 2001;12:96-8.
Satlin 1992 {published data only}
  • Satlin A, Volicer L, Ross V, Herz L, Campbell S. Bright light treatment of behavioral and sleep disturbances in patients with Alzheimer's disease. American Journal of Psychiatry 1992;149:1028-32.
Skjerve 2004 {published data only}
Sloane 2007 {published data only}
Thorpe 2000 {published data only}
  • Thorpe L, Middleton J, Russell G, Stewart N. Bright light therapy for demented nursing home patients with behavioral disturbance. American Journal of Alzheimer's Disease 2000;15(1):18-26.
Van Hoof 2009 {published data only}
  • Van Hoof J, Aarts MPJ, Rense CG, Schoutens AMC. Ambient bright light in dementia: effects on behaviour and circadian rhythmicity. Building and Environment 2009;44(1):146-55.
van Someren 1997 {published data only}
  • van Someren EJW, Kessler A, Mirmiran M, Swaab DF. Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients. Biological Psychiatry 1997;41:955-63.
Yamadera 2000 {published data only}

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Most 2010 {published data only}
  • Most EI, Scheltens P, Van Someren EJ. Prevention of depression and sleep disturbances in elderly with memory-problems by activation of the biological clock with light--a randomized clinical trial. Trials 2010;11:19.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
APA 1995
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ASC 2013
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Balk 2002
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Campbell 1995
David 2010
  • David R, Zeitzer J, Friedman L, Noda A, O'Hara R, Robert P, Yesavage JA. Non pharmacologic management of sleep disturbance in Alzheimer's disease. The Journal of Nutrition, Health & Aging 2010;14(3):203-6.
Davis 2001
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Feldman 2005
Folstein 1975
Harper 2001
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Harper 2008
  • Harper D, Stopa EG, Kuo-Leblanc V, McKee AC, Asayama K, Volicer L, et al. Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia. Brain 2008;131(P6):1609–17.
Higgins 2002
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Hogan 2007
Kjaergard 2001
Kong 2009
Liu 2000
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Martin 2007
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Porta 2007
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Schulz 1995
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Shirani 2009
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Forbes 2004
  • Forbes D, Morgan DG, Bangma J, Peacock S, Adamson J. Light therapy for managing sleep, behaviour, and mood disturbances in dementia. Cochrane Database of Systematic Reviews 2004, Issue 2.
Forbes 2009
  • Forbes D, Culum I, Lischka AR, Morgan DG, Peacock S, Forbes J, Forbes S. Light therapy for managing cognitive, sleep, functional, behavioural, or mood disturbances in dementia. Cochrane Database of Systematic Reviews 2009, Issue 4. [DOI: 10.1002/14651858C; : ]