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Topical agents and dressings for fungating wounds

  1. Una J Adderley*,
  2. Ian GS Holt

Editorial Group: Cochrane Wounds Group

Published Online: 15 MAY 2014

Assessed as up-to-date: 2 AUG 2013

DOI: 10.1002/14651858.CD003948.pub3


How to Cite

Adderley UJ, Holt IGS. Topical agents and dressings for fungating wounds. Cochrane Database of Systematic Reviews 2014, Issue 5. Art. No.: CD003948. DOI: 10.1002/14651858.CD003948.pub3.

Author Information

  1. University of Leeds, School of Healthcare, Leeds, UK

*Una J Adderley, School of Healthcare, University of Leeds, Room 2.22, Baines Wing, Leeds, LS2 9JT, UK. u.adderley@leeds.ac.uk. uadderley@talktalk.net.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 15 MAY 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bower 1992 {published data only}
  • Bower M, Stein R, Evans TR, Hedley A, Pert P, Coombes RC. A double-blind study of the efficacy of metronidazole gel in the treatment of malodorous fungating tumours. European Journal of Cancer 1992;28A(4-5):888-9.
Kalemikerakis 2012 {published data only}
  • Kalemikerakis J. Comparison of foam dressings with silver versus foam dressings without silver in the care of malodorous malignant fungating wounds. Journal of B.U.On 2012;17(3):560-4.
Leonard 2001 {published data only}
  • Leonard R, Hardy J, van Tienhoven G, Houston S, Simmonds P, David M, et al. Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer. Journal of Clinical Oncology 2001;19(21):4150-9.
Lund-Nielsen 2011a {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Ashford 1984 {published data only}
  • Ashford R, Plant G, Maher J, Teare L. Double blind trial of metronidazole in malodorous ulcerating tumours. Lancet 1984;June 2:1232-3.
Bale 2004 {published and unpublished data}
  • Bale S, Tebbie N, Price P. A topical metronidazole gel used to treat malodorous wounds. British Journal of Nursing 2004;13(11):4S-11S.
Clive 1999 {published data only}
  • Clive S, Gardiner J, Leonard RC. Miltefosine as a topical treatment for cutaneous metastases in breast carcinoma. Cancer Chemotherapy Pharmacology 1999;44(Suppl):29S-30S.
Efendiev 1991 {published data only}
  • Efendiev AI, Tolstykh PI, Dadashev AI, Marshava AM. Topical prolonged enzyme therapy of purulent wounds. Khirurgiia (Mosk) 1991;Jul(7):48-50.
Gostishchev 1983 {published data only}
  • Gostishchev VK, Vasilkova ZF, Khanin AG, Vavilova GS, Lebedskoj AG. Debrisan in the treatment of purulent wounds. Vestnik Chirurgii Imemi Grekova 1983;131(9):56-9.
Gostishchev 1985 {published data only}
  • Gostishchev VK, Tolstykh PI, Khanin AG, Vasilkova ZF, Yusupuv KA, Vlasov, LT, et al. The use of Trypsin immobilised on textile cellulose matrix in the treatment of purulent wounds of soft tissues. Vestnik Chirurgii Imemi Grekova 1985;134(6):68-71.
Gostishchev 1993 {published data only}
  • Gotstishchev VK, Mulyaev LF, Nikolaev AV, Khanin AG, Kassin VY. Regenkur, a polymer sorbent, in the treatment of purulent wounds. Khirurgiya 1993;69(11):3-6.
Grocott 2001a {published data only}
  • Grocott P, Cowley S. The palliative management of fungating malignant wounds - generalising from multiple-case study data using a system of reasoning. International Journal of Nursing Studies 2001;38(5):533-45.
Healy 1969 {published data only}
  • Healy JB. The use of topical 5-fluorouracil. Journal of the Irish Medical Association 1969;62(380):41-6.
Ingle 2006 {published data only}
Lo 2010 {published data only}
  • Lo SF. A cost-effectiveness analysis of a silver dressing for malignant fungating wound of cancer patients. EWMA Journal 2010;10:P116.
Lo 2010a {published data only}
  • Lo SF, Huang CU. The effect wound bed status of a ionic silver dressings in cancer patients with malignant fungating wound. EWMA Journal. 2010; Vol. 10:P28.
Lo 2012 {published data only}
Lund-Nielsen 2008 {published data only}
  • Lund-Nielsen B. Malignant wounds. A randomised clinical trial investigating a complimentary multidimensional intervention. EWMA Conference. 2008; Vol. 8, issue 2 (Supp):49, Abstract no. 60.
Lund-Nielsen 2011 {published data only}
  • Lund-Nielsen B, Adamsen L, Gottrup F, Rorth M, Tolver A, Kolmos HJ. Qualitative bacteriology in malignant wounds - A prospective randomized clinical study to compare the effect of honey and silver dressings. Ostomy/Wound Management 2011;57(7):28-36.
Moller 2000 {published data only}
  • Moller F, Jakobsen V, Jensen K. Performance of Contreet antibacterial hydrocolloid dressing compared to other antibacterial dressings. Tenth Annual Meeting of the European Tissue Repair Society; 2000, 24-27 May; Brussels, Belgium. Brussels, 2000:A427.
Russell 2001 {published data only}
  • Russell L, Deeth M, Jones HM, Reynolds T. Vacutex capillary action dressing: a multicentre, randomized trial. British Journal of Nursing 2001;10(11):66S-70S.
Stuwe 1983 {published data only}
Taranenko 1984 {published data only}
  • Taranenko LD, Bondarev VI, Nefedov GP, Shlopov VG, Verkhuletsky IE, Kuznetsov AS. Experience in the use of SKN-1K sorbent in the treatment of purulent wounds. Klinichna Khirurhiia 1984;Jan(1):44-7.
Udwadia 2011 {published data only}
Upright 1994 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Alexander 2009a
  • Alexander S. Malignant fungating wounds: epidemiology, aetiology, presentation and assessment. Journal of Wound Care 2009;18(7):273-80.
Alexander 2009b
  • Alexander S. Malignant fungating wounds: key symptoms and psychosocial. Journal of Wound Care 2009;18(8):325-9.
Bale 1991
  • Bale S, Harding K. Fungating breast wounds. Journal of District Nursing 1991;9(12):4-5.
Bridel-Nixon 1997
  • Bridel-Nixon J. Other chronic wounds. In: Morison M, Moffatt C, Bridel-Nixon J, Bale S editor(s). Nursing Management of Chronic Wounds. 1st Edition. London: Mosby, 1997:221-45.
de Haes 1996
  • Haes JCJM de, Olschewski M, Fayers P, Visser MRM, Cull A, Hopwood P, Sanderman, R. Measuring the quality of life of cancer patients with the Rotterdam Symptom Checklist: a manual. Groningen, the Netherlands: Noordelijk Centrum voor Gezondheidsvraagstukken / Northern Centre for Healthcare Research. University of Groningen, 1996.
Fairburn 1994
  • Fairburn K. A challenge that requires further research. Management of fungating breast lesions. Professional Nurse 1994;9:272-7.
Gibson 2013
Grocott 1995
  • Grocott P. The palliative management of fungating malignant wounds. Journal of Wound Care 1995;4(5):240-2.
Grocott 2001b
  • Grocott P. Developing a tool for researching fungating wounds. World Wide Wounds 2001; Vol. http://www.worldwidewounds.com/2001/july/Grocott/Fungating-Wounds.html.
Grocott 2002
  • Grocott P. A review of advances in fungating wound management since EWMA 1991. EWMA Journal 2002;2(1):21-4.
Haughton 1995
  • Haughton W, Young T. Common problems in wound care: malodorous wounds. British Journal of Nursing 1995;4(16):959-63.
Higgins 2003
Higgins 2011
  • Higgins JPT, Altman DG, on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group (Editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org. Available from www.cochrane-handbook.org.
Hirst 1992
  • Hirst DG. Tumour vascular physiology. Annual report of the Cancer Research Campaign Grey Laboratory 1992.
Kelly 2002
  • Kelly N. Malodorous fungating wounds: a review of current literature. Professional Nurse 2002;17(5):323-6.
KLONK 2014
  • KLONK. KLONK Image Measurement. http://www.imagemeasurement.com/ (accessed February 15 2014).
Lefebrve 2011
  • Lefebvre C, Manheimer E, Glanville J, on behalf of the Cochrane Information Retrieval Methods Group. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Lo 2008
Lund-Nielson 2005
Melzack 1987
Probst 2013
Selby 2009
  • Selby T. Managing exudate in malignant fungating wounds and solving problems for patients. Nursing Times 2009;105(18):14-17.
SIGN 2008
  • Scottish Intercollegiate Guidelines Network (SIGN). Search filters. Available from http://www.sign.ac.uk/methodology/filters.html#random (accessed August 2008).
WHO 1979
  • World Health Organisation. WHO Handbook for Reporting Results of Cancer Treatment. Geneva: World Health Organisation, 1979.