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Higher versus lower protein intake in formula-fed low birth weight infants

  1. Tanis R Fenton1,2,*,
  2. Shahirose S Premji3,
  3. Heidi Al-Wassia4,5,
  4. Reg S Sauve5

Editorial Group: Cochrane Neonatal Group

Published Online: 21 APR 2014

Assessed as up-to-date: 18 JUN 2013

DOI: 10.1002/14651858.CD003959.pub3


How to Cite

Fenton TR, Premji SS, Al-Wassia H, Sauve RS. Higher versus lower protein intake in formula-fed low birth weight infants. Cochrane Database of Systematic Reviews 2014, Issue 4. Art. No.: CD003959. DOI: 10.1002/14651858.CD003959.pub3.

Author Information

  1. 1

    University of Calgary, Alberta Children's Hospital Research Institute, Department of Community Health Sciences, Faculty of Medicine, Calgary, Canada

  2. 2

    Alberta Health Services, Nutrition Services, Calgary, Canada

  3. 3

    University of Calgary, Faculty of Nursing, Calgary, Alberta, Canada

  4. 4

    King Abdulaziz University, Department of Pediatrics, Division of Neonatology, Faculty of Medicine, Jeddah, Saudi Arabia

  5. 5

    University of Calgary, Department of Pediatrics and Community Health Sciences, Faculty of Medicine, Calgary, Canada

*Tanis R Fenton, Alberta Children's Hospital Research Institute, Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, Canada. tfenton@ucalgary.ca.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 21 APR 2014

SEARCH

[Analysis 1.1]
Analysis 1.1. Comparison 1 High versus low protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 1 Growth parameters.
[Analysis 1.2]
Analysis 1.2. Comparison 1 High versus low protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 2 Nitrogen utilization.
[Analysis 1.3]
Analysis 1.3. Comparison 1 High versus low protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 3 Nitrogen balance.
[Analysis 1.4]
Analysis 1.4. Comparison 1 High versus low protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 4 Phenylalanine levels.
[Analysis 1.5]
Analysis 1.5. Comparison 1 High versus low protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 5 Necrotizing enterocolitis.
[Analysis 1.6]
Analysis 1.6. Comparison 1 High versus low protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 6 Metabolic acidosis (pH, base excess).
[Analysis 1.7]
Analysis 1.7. Comparison 1 High versus low protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 7 Serum albumin (g/L).
[Analysis 1.8]
Analysis 1.8. Comparison 1 High versus low protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 8 Sepsis.
[Analysis 1.9]
Analysis 1.9. Comparison 1 High versus low protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 9 Diarrhea.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Very high versus high protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 1 Growth parameters at discharge.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Very high versus high protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 2 Growth parameters at term.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Very high versus high protein intake (restricted to studies meeting all a priori inclusion criteria), Outcome 3 Growth parameters at 12 weeks corrected age.
[Analysis 4.1]
Analysis 4.1. Comparison 4 High versus low protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 1 Growth parameters.
[Analysis 4.2]
Analysis 4.2. Comparison 4 High versus low protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 2 Nitrogen utilization.
[Analysis 4.3]
Analysis 4.3. Comparison 4 High versus low protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 3 Nitrogen balance.
[Analysis 4.4]
Analysis 4.4. Comparison 4 High versus low protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 4 Phenylalanine levels.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Very high versus low protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 1 Weight gain (g/wk).
[Analysis 5.2]
Analysis 5.2. Comparison 5 Very high versus low protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 2 Linear growth (cm/wk).
[Analysis 5.3]
Analysis 5.3. Comparison 5 Very high versus low protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 3 Phenylalanine levels.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Very high versus high protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 1 Growth parameters.
[Analysis 6.2]
Analysis 6.2. Comparison 6 Very high versus high protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 2 Nitrogen utilization.
[Analysis 6.3]
Analysis 6.3. Comparison 6 Very high versus high protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 3 Nitrogen balance.
[Analysis 6.4]
Analysis 6.4. Comparison 6 Very high versus high protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 4 Low IQ or Bayley score at 18 months and/or later (all infants).
[Analysis 6.5]
Analysis 6.5. Comparison 6 Very high versus high protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 5 Low IQ or Bayley score at 18 months and/or later (in infants < 1300 g).
[Analysis 6.6]
Analysis 6.6. Comparison 6 Very high versus high protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 6 Phenylalanine levels.
[Analysis 6.7]
Analysis 6.7. Comparison 6 Very high versus high protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 7 Metabolic acidosis (base excess).
[Analysis 6.8]
Analysis 6.8. Comparison 6 Very high versus high protein intake (adding studies comparing formulas with differences in other nutrients), Outcome 8 Serum albumin (g/L).