Intervention Review

Tacrolimus versus cyclosporin as primary immunosuppression for kidney transplant recipients

  1. Angela C Webster1,*,
  2. Rod RS Taylor2,
  3. Jeremy R Chapman3,
  4. Jonathan C Craig4

Editorial Group: Cochrane Renal Group

Published Online: 19 OCT 2005

Assessed as up-to-date: 21 AUG 2005

DOI: 10.1002/14651858.CD003961.pub2

How to Cite

Webster AC, Taylor RRS, Chapman JR, Craig JC. Tacrolimus versus cyclosporin as primary immunosuppression for kidney transplant recipients. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD003961. DOI: 10.1002/14651858.CD003961.pub2.

Author Information

  1. 1

    University of Sydney, School of Public Health, Sydney, NSW, Australia

  2. 2

    Peninsula Medical School, PenTAG, Exeter, UK

  3. 3

    Westmead Hospital, Renal Medicine, Westmead, NSW, Australia

  4. 4

    The Children's Hospital at Westmead, Centre for Kidney Research, Westmead, NSW, Australia

*Angela C Webster, School of Public Health, University of Sydney, Edward Ford Building A27, Sydney, NSW, 2006, Australia.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 19 OCT 2005


Cited in:


This article has been cited by:

  1. 1
    Shahram Shahangian, Todd D. Alspach, J. Rex Astles, Ajay Yesupriya, William K. Dettwyler, Trends in Laboratory Test Volumes for Medicare Part B Reimbursements, 2000–2010, Archives of Pathology & Laboratory Medicine, 2014, 138, 2, 189


  2. 2
    David Rush, The impact of calcineurin inhibitors on graft survival, Transplantation Reviews, 2013, 27, 3, 93


  3. 3
    George Melvin, Selvarajan Sandhiya, Kumaresan Subraja, Authors′ reply, Journal of Pharmacology and Pharmacotherapeutics, 2012, 3, 1, 83


  4. 4
    J. Barba, D. Rosell, A. Rincon, J.E. Robles, J. Zudaire, J.M. Berian, I. Pascual, P. Errasti, New Immunosuppressive Therapies and Surgical Complications After Renal Transplantation, Transplantation Proceedings, 2012, 44, 5, 1275


  5. 5
    C. J. Yates, S. Fourlanos, J. Hjelmesæth, P. G. Colman, S. J. Cohney, New-Onset Diabetes After Kidney Transplantation—Changes and Challenges, American Journal of Transplantation, 2012, 12, 4
  6. 6
    Rajat Dhar, Theresa Human, Central Nervous System Complications After Transplantation, Neurologic Clinics, 2011, 29, 4, 943


  7. 7
    Nassim Kamar, Cyril Garrouste, Elizabeth B. Haagsma, Valérie Garrigue, Sven Pischke, Cécile Chauvet, Jérome Dumortier, Amélie Cannesson, Elisabeth Cassuto–Viguier, Eric Thervet, Filomena Conti, Pascal Lebray, Harry R. Dalton, Robert Santella, Nada Kanaan, Marie Essig, Christiane Mousson, Sylvie Radenne, Anne Marie Roque–Afonso, Jacques Izopet, Lionel Rostaing, Factors Associated With Chronic Hepatitis in Patients With Hepatitis E Virus Infection Who Have Received Solid Organ Transplants, Gastroenterology, 2011, 140, 5, 1481


  8. 8
    Simon Urschel, Luis A. Altamirano-Diaz, Lori J. West, Immunosuppression Armamentarium in 2010: Mechanistic and Clinical Considerations, Pediatric Clinics of North America, 2010, 57, 2, 433


  9. 9
    Thomas G. Gross, Barbara Savoldo, Angela Punnett, Posttransplant Lymphoproliferative Diseases, Pediatric Clinics of North America, 2010, 57, 2, 481


  10. 10
    Valter D. Garcia, Deise B.M. Carvalho, Renato T. Gonçalves, Ruy L. Cavalcanti, Henry H. Campos, Mário Abbud-Filho, Abner A. Lobao-Neto, Randomized trial of early corticosteroid reduction vs. regular-dose corticosteroid maintenance in combination with tacrolimus and mycophenolate mofetil in living donor kidney transplant recipients: the Brazilian CORRETA trial, Clinical Transplantation, 2010, 24, 4
  11. You have free access to this content11
    Lutz Liefeldt, Klemens Budde, Risk factors for cardiovascular disease in renal transplant recipients and strategies to minimize risk, Transplant International, 2010, 23, 12
  12. 12
    S.P. Steigerwalt, N. Brar, A. Dhungel, D. Butcher, S. Steigerwalt, M. El-Ghouroury, R. Provenzano, Improved 24-Hour Blood Pressure Control With Sirolimus Versus Calcineurin Inhibitor Based Immunosuppression in Renal Transplant Recipients, Transplantation Proceedings, 2009, 41, 10, 4184


  13. 13
    Laurence J. Egan, Pharmacology and Therapeutics, 2009,


  14. 14
    Binu S. Mathew, Denise H. Fleming, Visalakshi Jeyaseelan, Sujith J. Chandy, V. M. Annapandian, P. K. Subbanna, George T. John, A limited sampling strategy for tacrolimus in renal transplant patients, British Journal of Clinical Pharmacology, 2008, 66, 4
  15. 15
    S.P.L. Travis, E.F. Stange, M. Lémann, T. Øresland, W.A. Bemelman, Y. Chowers, J.F. Colombel, G. D'Haens, S. Ghosh, P. Marteau, W. Kruis, N.J.McC. Mortensen, F. Penninckx, M. Gassull, European evidence-based Consensus on the management of ulcerative colitis: Current management, Journal of Crohn's and Colitis, 2008, 2, 1, 24


  16. 16
    Ali Gürkan, Beral Afacan, Gülnur Emingil, Hüseyin Töz, Aykut Başkesen, Gül Atilla, Gingival crevicular fluid transforming growth factor-β1 in cyclosporine and tacrolimus treated renal transplant patients without gingival overgrowth, Archives of Oral Biology, 2008, 53, 8, 723


  17. 17
    A. Sharma, M. Minz, S. Singh, Incidence of Glucose Metabolic Abnormalities in Indian Living Renal Allograft Recipients on Tacrolimus-Based Triple Drug Immunosuppression, Transplantation Proceedings, 2008, 40, 7, 2414


  18. 18
    Pilar Martín-Dávila, Marino Blanes, Jesús Fortún, Inmunosupresión e infección en el paciente trasplantado, Enfermedades Infecciosas y Microbiología Clínica, 2007, 25, 2, 143


  19. 19
    Selda Emre Aydingoz, Steven K. Takemoto, Brett W. Pinsky, Paolo R. Salvalaggio, Krista L. Lentine, Lisa Willoughby, Beverly Hoover, Thomas A. Burroughs, Mark A. Schnitzler, Ralph Graff, The impact of human leukocyte antigen matching on transplant complications and immunosuppression dosage, Human Immunology, 2007, 68, 6, 491


  20. 20
    Luit Penninga, Elisabeth I Penninga, Christian H Møller, Martin Iversen, Daniel A Steinbrüchel, Christian Gluud, Tacrolimus versus cyclosporin as primary immunosuppression for lung transplant recipients, The Cochrane Library,
  21. 21
    Shishu Huang, Dan Long, Xin Duan, Na Zhao, Shengfu Li, Liang Du, Youping Li, Tacrolimus versus cyclosporin for simultaneous pancreas-kidney transplant recipients, The Cochrane Library,