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Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients

  1. Liat Vidal1,*,
  2. Itsik Ben dor1,
  3. Mical Paul2,
  4. Noa Eliakim-Raz1,
  5. Ellisheva Pokroy3,
  6. Karla Soares-Weiser4,
  7. Leonard Leibovici1

Editorial Group: Cochrane Gynaecological Cancer Group

Published Online: 9 OCT 2013

Assessed as up-to-date: 31 JAN 2013

DOI: 10.1002/14651858.CD003992.pub3


How to Cite

Vidal L, Ben dor I, Paul M, Eliakim-Raz N, Pokroy E, Soares-Weiser K, Leibovici L. Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD003992. DOI: 10.1002/14651858.CD003992.pub3.

Author Information

  1. 1

    Beilinson Hospital, Rabin Medical Center, Department of Medicine E, Petah Tikva, Israel

  2. 2

    Rambam Health Care Campus, Division of Infectious Diseases, Haifa, Israel

  3. 3

    Beilinson Hospital, Rabin Medical Center, Department of Medicine A, Petah Tikva, Israel

  4. 4

    Enhance Reviews Ltd, Wantage, UK

*Liat Vidal, Department of Medicine E, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski Street, Petah Tikva, 49100, Israel. vidallit@yahoo.com. VidalL2@clalit.org.il.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 9 OCT 2013

SEARCH

[Figure 1]
Figure 1. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Funnel plot of comparison: 1 Oral versus intravenous antibiotic therapy, outcome: 1.1 Mortality.
[Figure 4]
Figure 4. Funnel plot of comparison: 1 Oral versus intravenous antibiotic therapy, outcome: 1.3 Treatment failure - per protocol analysis.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Oral versus intravenous antibiotic therapy, Outcome 1 Mortality.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Oral versus intravenous antibiotic therapy, Outcome 2 Treatment failure.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Oral versus intravenous antibiotic therapy, Outcome 3 Treatment failure - per protocol analysis.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Oral versus intravenous antibiotic therapy, Outcome 4 Adverse events requiring discontinuation of antibiotics.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Oral versus intravenous antibiotic therapy, Outcome 5 Gastrointestinal adverse events ('post-protocol' analysis).
[Analysis 1.6]
Analysis 1.6. Comparison 1 Oral versus intravenous antibiotic therapy, Outcome 6 Lost to follow-up.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Oral versus intravenous antibiotic therapy, Outcome 7 Treatment failure not dt modification in update.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Oral versus intravenous antibiotic therapy - subgroup analysis, Outcome 1 Treatment failure - age.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Oral versus intravenous antibiotic therapy - subgroup analysis, Outcome 2 Treatment failure - source of infection.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Oral versus intravenous antibiotic therapy - subgroup analysis, Outcome 3 Treatment failure - severity of neutropenia.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Oral versus intravenous antibiotic therapy - subgroup analysis, Outcome 4 Treatment failure - type of malignancy.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Methodological quality of studies, Outcome 1 Allocation concealment.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Post hoc subgroup analyses, Outcome 1 Setting.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Post hoc subgroup analyses, Outcome 2 Type of oral antibiotics.