Intervention Review

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Steroids for idiopathic sudden sensorineural hearing loss

  1. Benjamin PC Wei1,2,
  2. Dimitra Stathopoulos1,
  3. Stephen O'Leary1,*

Editorial Group: Cochrane ENT Group

Published Online: 2 JUL 2013

Assessed as up-to-date: 22 APR 2013

DOI: 10.1002/14651858.CD003998.pub3


How to Cite

Wei BPC, Stathopoulos D, O'Leary S. Steroids for idiopathic sudden sensorineural hearing loss. Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD003998. DOI: 10.1002/14651858.CD003998.pub3.

Author Information

  1. 1

    Royal Victorian Eye and Ear Hospital/University of Melbourne, Department of Otolaryngology, Melbourne, Victoria 3002, Australia

  2. 2

    Royal Victorian Eye and Ear Hospital/University of Melbourne, Department of Surgery, Melbourne, Australia

*Stephen O'Leary, Department of Otolaryngology, Royal Victorian Eye and Ear Hospital/University of Melbourne, 32 Gisborne Street, Melbourne, Victoria 3002, Australia. sjoleary@unimelb.edu.au.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 2 JUL 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Cinamon 2001 {published data only}
Nosrati-Zarenoe 2012 {published data only}
  • Nosrati-Zarenoe R. Idiopathic Sudden Sensorineural Hearing Loss. Corticosteroid Treatment, the Diagnostic Protocol and Outcome. Linköping University medical dissertation No. 1229. Linköping, Sweden: Linköping University, 2011.
  • Nosrati-Zarenoe R, Hultcrantz E. Corticosteroid treatment of idiopathic sudden sensorineural hearing loss. Part 1: a randomized triple-blind placebo controlled trial. http://mdh.diva-portal.org/smash/record.jsf?pid=diva2:411770.
  • Nosrati-Zarenoe R, Hultcrantz E. Corticosteroid treatment of idiopathic sudden sensorineural hearing loss: randomized triple-blind placebo-controlled trial. Otology & Neurotology 2012;33(4):523-31.
Wilson 1980 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Ahn 2006 {published data only}
Ahn 2010 {published data only}
Ai 2009 {published data only}
  • Ai W, Tong B, Liu Y, Duan M. Analysis of clinical characteristics and treatment outcome of bilateral and unilateral sudden sensorineural hearing loss. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009;23:307-10.
Alexiou 1999 {published data only}
  • Alexiou Ch, Arnold W, Fauser C, Gloddek B, Fuhrmann S, Lamm K. Influence of glucocorticoids in the treatment of sudden sensorineural hearing loss. Oto-Rhino-Laryngologia Nova 1999;9(3-4):98-104.
Alimoglu 2011 {published data only}
  • Alimoglu Y, Inci E, Edizer DT, Ozdilek A, Aslan M. Efficacy comparison of oral steroid, intratympanic steroid, hyperbaric oxygen and oral steroid + hyperbaric oxygen treatments in idiopathic sudden sensorineural hearing loss cases. European Archives of Oto-Rhino-Laryngology 2011;268:1735-41.
Angeli 2012 {published data only}
  • Angeli SI, Abi-Hachem RN, Vivero RJ, Telischi FT, Machado JJ. L-N-acetylcysteine treatment is associated with improved hearing outcome in sudden idiopathic sensorineural hearing loss. Acta Oto-Laryngologica 2012;132:369-76.
Aoki 2006 {published data only}
Arellano 1997 {published data only}
  • Arellano B, Garcia Berrocal JR, Gorriz C, Gonzalez FM, Vicente J, Ramirez Camacho R. Treatment protocol for sudden deafness [Protocolo de tratamiento de la sordera subita]. Acta Otorrinolaringologica Espanola 1997;48(7):513-6.
Arslan 2011 {published data only}
  • Arslan N, Oguz H, Demirci M, Safak MA, Islam A, Kaytez SK, et al. Combined intratympanic and systemic use of steroids for idiopathic sudden sensorineural hearing loss. Otology and Neurotology 2011;32:393-7.
Asada 1998 {published data only}
  • Asada Y, Suzuki H, Nakabayashi S, Furukawa M. High dose steroid therapy for sudden deafness - efficacy in severe cases. Journal of the Oto-rhino-laryngological Society of Japan 1998;101:1069-74.
Bae 2013 {published data only}
  • Bae SC,  Noh HI,  Jun BC,  Jeon EJ,  Seo JH,  Park SY, et al. Efficacy of intratympanic steroid therapy for idiopathic sudden sensorineural hearing loss: comparison with systemic steroid therapy and combined therapy. Acta Oto-Laryngologica 2013 Jan 28 [Epub ahead of print].
Barriat 2012 {published data only}
  • Barriat S, van Wijck F, Staecker H, Lefebvre PP. Intratympanic steroid therapy using the Silverstein Microwick for refractory sudden sensorineural hearing loss increases speech intelligibility. Audiology and Neuro-Otology 2012;17:105-11.
Battaglia 2008 {published data only}
  • Battaglia A, Burchette R, Cueva R. Combination therapy (intratympanic dexamethasone + high-dose prednisone taper) for the treatment of idiopathic sudden sensorineural hearing loss. Otology and Neurotology 2008;29:453-60.
Baysal 2013 {published data only}
  • Baysal E,  Tunç O,  Baglam T,  Durucu C,  Oz A,  Karatas ZA, et al. Systemic steroid versus combined systemic and intratympanic steroid treatment for sudden sensorineural hearing loss. Journal of Craniofacial Surgery 2013;24(2):432-4.
Behnoud 2009 {published data only}
  • Behnoud F, Goodarzi MT. The treatment of idiopathic sudden sensorineural hearing loss using phlebotomy: a prospective, randomized, double-blind clinical trial. Acta Medica Iranica 2009;47:439-42.
Bianchin 2010 {published data only}
Bittar 2009 {published data only}
  • Bittar RS, Oiticica J, Zerati FE, Bento RF. Sudden hearing loss: a ten-year outpatient experience. International Tinnitus Journal 2009;15:196-202.
Byl 1984 {published data only}
Cekin 2009 {published data only}
Chan 2009 {published data only}
  • Chan A, Tong M, Lee A, Wong E, Abdullah V. A randomized controlled trial on intratympanic steroid treatment for sudden onset sensorineural hearing loss. The Chinese University of Hong Kong 2009 (accessed 9 May 2013).
Chandrasekhar 2001 {published data only}
Chen 2003 {published data only}
Chen 2010 {published data only}
  • Chen Y, Wen L, Hu P, Qiu J, Lu L, Qiao L. Endoscopic intratympanic methylprednisolone injection for treatment of refractory sudden sensorineural hearing loss and one case in pregnancy. Journal of Otolaryngology - Head & Neck Surgery 2010;39:640-5.
Chen 2011 {published data only}
  • Chen X, Yu LS, Xia RM. Analysis of the effectiveness in patients who were treated with a course of drugs for sudden deafness which was present for at least three weeks. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2011;46:539-42.
Choi 2011 {published data only}
  • Choi SY, Lee YH, Kim YH. Comparison of the efficacy of systemic and combined highly frequent intratympanic steroid treatment on sudden sensorineural hearing loss. Korean Journal of Audiology 2011;15:133-6.
Choung 2005 {published data only}
  • Choung YH, Park K, Mo JY, Oh JH, Kim JS. The effects of intratympanic steroid injection for the patients with refractory sudden sensorineural hearing loss. Korean Journal of Otolaryngology - Head and Neck Surgery 2005;48:706-12.
Clary 2011 {published data only}
  • Clary M, Murray RC, Loftus P, Dervishaj O, Keith S, Willcox TO, et al. Clinical outcomes in idiopathic sudden sensorineural hearing loss. Laryngoscope 2011;121:S315.
Dallan 2010 {published data only}
  • Dallan I, De Vito A, Fattori B, Casani AP, Panicucci E, Berrettini S, et al. Intratympanic methylprednisolone in refractory sudden hearing loss: a 27-patient case series with univariate and multivariate analysis. Otology & Neurotology 2010;31:25-30.
Dallan 2011 {published data only}
  • Dallan I, Fortunato S, Casani AP, Panicucci E, Berrettini S, Lenzi R, et al. Intratympanic methylprednisolone as first-line therapy in sudden sensorineural hearing loss: preliminary results from a case-control series. Journal of Laryngology and Otology 2011;125:1004-8.
Dauman 1985 {published data only}
  • Dauman R, Cros A, Poisot D. Treatment of sudden deafness: first results of a comparative study [Traitements des surdites brusques: premiers resultats d'une etude comparative]. Journal of Otolaryngology 1985;14(1):49-56.
Dispenza 2011 {published data only}
  • Dispenza F, Amodio E, De Stefano A, Gallina S, Marchese D, Mathur N, et al. Treatment of sudden sensorineural hearing loss with transtympanic injection of steroids as single therapy: a randomized clinical study. European Archives of Oto-Rhino-Laryngology 2011;268:1273-8.
Echarri 2000 {published data only}
  • Echarri RM, Rivera T, Mate MA, Cobeta I. Sudden hearing loss: effectiveness of a therapeutic protocol [Soddera brusca: eficacia de ub protocolo terapeutico]. Acta Otorrhinolaryngologica Espanola 2000;51(6):490-4.
Edamatsu 1985 {published data only}
Filipo 2010 {published data only}
  • Filipo R, Covelli E, Balsamo G, Attanasio G. Intratympanic prednisolone therapy for sudden sensorineural hearing loss: a new protocol. Acta Oto-Laryngologica 2010;130:1209-13.
Filipo 2012 {published data only}
  • Filipo R, Attanasio G, Viccaro M, Russo FY, Mancini P, Rocco M, et al. Hyperbaric oxygen therapy with short duration intratympanic steroid therapy for sudden hearing loss. Acta Oto-Laryngologica 2012;132:475-81.
Fu 2011 {published data only}
  • Fu Y, Zhao H, Zhang T, Chi F. Intratympanic dexamethasone as initial therapy for idiopathic sudden sensorineural hearing loss: clinical evaluation and laboratory investigation. Auris Nasus Larynx 2011;38:165-71.
Fujimura 2007 {published data only}
  • Fujimura T, Suzuki H, Shiomori T, Udaka T, Mori T. Hyperbaric oxygen and steroid therapy for idiopathic sudden sensorineural hearing loss. European Archives of Oto-Rhino-Laryngology 2007;264(8):861-6.
Fuse 2002 {published data only}
  • Fuse T, Aoyagi M, Funakubo T, Sakakibara A, Yoshida S. Short-term outcome and prognosis of acute low-tone sensorineural hearing loss by administration of steroid. ORL; Journal of Oto-Rhino-Laryngology & its Related Specialties 2002;64(1):6-10.
Gianoli 2001 {published data only}
Gouveris 2005 {published data only}
  • Gouveris H, Selivanova O, Mann W. Intratympanic dexamethasone with hyaluronic acid in the treatment of idiopathic sudden sensorineural hearing loss after failure of intravenous steroid and vasoactive therapy. European Archives of Oto-Rhino-Laryngology 2005;262(2):131-4.
Gouveris 2011 {published data only}
  • Gouveris H, Schuler-Schmidt W, Mewes T, Mann W. Intratympanic dexamethasone/hyaluronic acid mix as an adjunct to intravenous steroid and vasoactive treatment in patients with severe idiopathic sudden sensorineural hearing loss. Otology & Neurotology 2011;32:756-60.
Grandis 1993 {published data only}
Han 2008 {published data only}
  • Han CS, Park JR, Kim HB, Ahn JK, Park JH, Kang MK, et al. Comparison of the efficacy of systemic and intratympanic steroid treatment on sudden sensorineural hearing loss with diabetes. Korean Journal of Otorhinolaryngology - Head and Neck Surgery 2008;51:227-33.
Han 2009 {published data only}
  • Han CS, Park JR, Boo SH, Jo JM, Park KW, Lee WY, et al. Clinical efficacy of initial intratympanic steroid treatment on sudden sensorineural hearing loss with diabetes. Otolaryngology - Head and Neck Surgery 2009;141:572-8.
Herr 2005 {published data only}
Hong 2009 {published data only}
  • Hong SM, Park CH, Lee JH. Hearing outcomes of daily intratympanic dexamethasone alone as a primary treatment modality for ISSHL. Otolaryngology - Head and Neck Surgery 2009;141:579-83.
Huang 1989 {published data only}
Hultcrantz 2012 {published data only}
  • Hultcrantz E, Nosrati-Zarenoe R. Corticosteroid treatment of idiopathic sudden sensorineural hearing loss. Part 2: a meta-analysis of a RCT and the Swedish national database. http://liu.diva-portal.org/smash/record.jsf?pid=diva2:411773 (accessed 3 June 2013).
Hunchaisri 2010 {published data only}
  • Hunchaisri N, Chantapant S, Srinangyam N. Intratympanic dexamethasone for refractory sudden sensorineural hearing loss. Journal of the Medical Association of Thailand 2010;93:1406-14.
Joong 2005 {published data only}
  • Joong HA, Mi RK, Hyang CK. Therapeutic effect of lipoprostaglandin E1 on sudden hearing loss. American Journal of Otolaryngology - Head and Neck Medicine and Surgery 2005;26:245-8.
Jun 2012 {published data only}
  • Jun HJ, Chang J, Im GJ, Kwon SY, Jung H, Choi J. Analysis of frequency loss as a prognostic factor in idiopathic sensorineural hearing loss. Acta Oto-Laryngologica 2012;132(6):590-6.
Kanzaki 1988 {published data only}
  • Kanzaki J, Taiji H, Ogawa K. Evaluation of hearing recovery and efficacy of steroid treatment in sudden deafness. Acta Oto-Laryngologica 1988;456:31-6.
Kanzaki 2003 {published data only}
  • Kanzaki J, Inoue Y, Ogawa K, Fukuda S, Fukushima K, Gyo K, et al. Effects of single-drug treatment on idiopathic sudden sensorineural hearing loss. Auris Nasus Larynx 2003;30:123-7.
Kara 2010 {published data only}
  • Kara E, Cetik F, Tarkan O, Suermelioglu O. Modified intratympanic treatment for idiopathic sudden sensorineural hearing loss. European Archives of Oto-Rhino-Laryngology 2010;267:701-7.
Kasapoglu 2009 {published data only}
  • Kasapoglu F, Tuzemen G, Hizalan I, Erisen L, Basut O, Onart S, et al. Prognosis in sudden hearing loss: is it the disease or the treatment that determines the prognosis?. Journal of International Advanced Otology 2009;5:187-94.
Kawamata 2007 {published data only}
  • Kawamata T, Ohki S, Sakuma T, Suzaki H. Combination steroid and hyperbaric oxygenation therapy for sudden idiopathic sensorineural hearing loss. Journal of the Oto-Rhino-Laryngological Society of Japan 2007;110(5):395-402.
Kim 2011a {published data only}
  • Kim YH, Park KT, Choi BY, Park MH, Lee JH, Oh SH, et al. Early combination treatment with intratympanic steroid injection in severe to profound sudden sensorineural hearing loss improves speech discrimination performance. European Archives of Oto-Rhino-Laryngology 2011;269(10):2173-8.
Kim 2011b {published data only}
  • Kim MG, Jung YG, Eun YG. Effect of steroid, carbogen inhalation, and lipoprostaglandin E(1) combination therapy for sudden sensorineural hearing loss. American Journal of Otolaryngology 2011;32:91-5.
Kitajiri 2002 {published data only}
  • Kitajiri S, Tabuchi K, Hiraumi H, Hirose T. Is corticosteroid therapy effective for sudden-onset sensorineural hearing loss at lower frequencies?. Archives of Otolaryngology - Head and Neck Surgery 2002;128(4):365-7.
Kitamura 1996 {published data only}
  • Kitamura K, Doi K, Takeda N, Mishiro Y, Okusa M, Kubo T. Statistical analysis of recovery from sudden deafness among treatment groups. Journal of the Oto-rhino-laryngological Society of Japan 1996;99(11):1676-83.
Kopke 2001 {published data only}
Kubo 1988 {published data only}
  • Kubo T, Matsunaga T, Asai H, Kawanoto K, Kusakari J, Nomura Y, et al. Efficacy of defibrinogenation and steroid therapies on sudden deafness. Archives of Otolaryngology - Head and Neck Surgery 1988;114(6):649-52.
Lee 2008 {published data only}
  • Lee HS, Kim JM, Kim YJ, Chung DH, Seo BS, Kim SH. Results of intratympanic dexamethasone injection as salvage treatment in idiopathic sudden hearing loss. Journal of Otolaryngology - Head & Neck Surgery 2008;37:263-8.
Lee 2011 {published data only}
  • Lee JB, Choi SJ, Park K, Park HY, Choo OS, Choung YH. The efficiency of intratympanic dexamethasone injection as a sequential treatment after initial systemic steroid therapy for sudden sensorineural hearing loss. European Archives of Oto-Rhino-Laryngology 2011;268:833-9.
Leong 1991 {published data only}
  • Leong HK, Loh KK. Prognostic factors in idiopathic sudden hearing loss. Annals Academy of Medicine Singapore 1991;20(5):624-7.
Li 2010 {published data only}
  • Li X, Wang R, Sun LJ, Jiang ZG, Fu ZQ, Guo Y, et al. Study of intratympanic methylprednisolone injections in diabetics with a sudden sensorineural hearing loss. Zhonghua Yi Xue Za Zhi 2010;90:3103-6.
Li 2011 {published data only}
  • Li P, Zeng XL, Ye J, Yang QT, Zhang GH, Li Y. Intratympanic methylprednisolone improves hearing function in refractory sudden sensorineural hearing loss: a control study. Audiology and Neuro-Otology 2011;16:198-202.
Lim 2013 {published data only}
  • Lim HJ,  Kim YT, Choi SJ, Lee JB, Park HY, Park K, et al. Efficacy of 3 different steroid treatments for sudden sensorineural hearing loss: a prospective, randomized trial. Otolaryngology - Head and Neck Surgery 2013;148(1):121-7.
Liu 2011 {published data only}
  • Liu SC, Kang BH, Lee JC, Lin YS, Huang KL, Liu DW, et al. Comparison of therapeutic results in sudden sensorineural hearing loss with/without additional hyperbaric oxygen therapy: a retrospective review of 465 audiologically controlled cases. Clinical Otolaryngology 2011;36:121-8.
Mattox 1977 {published data only}
Min 2011 {published data only}
  • Min HJ, Kim JM, Kim K, Park CW, Jeong JH, Lee SH. The combination effects of early intratympanic dexamethasone injection for patients with sudden sensorineural hearing loss. Otolaryngology - Head and Neck Surgery 2011;145:228-9.
Minoda 2000 {published data only}
  • Minoda R, Masuyama K, Habu K, Yumoto E. Initial steroid hormone dose in the treatment of idiopathic sudden deafness. American Journal of Otology 2000;21(6):819-25.
Moon 2011 {published data only}
  • Moon IS, Lee JD, Kim J, Hong SJ, Lee WS. Intratympanic dexamethasone is an effective method as a salvage treatment in refractory sudden hearing loss. Otology and Neurotology 2011;32:1432-6.
Mosges 2009 {published data only}
  • Mosges R, Koberlein J, Heibges A, Erdtracht B, Klingel R, Lehmacher W. Rheopheresis for idiopathic sudden hearing loss: results from a large prospective, multicenter, randomized, controlled clinical trial. European Archives of Oto-Rhino-Laryngology 2009;266:943-53.
Moskowitz 1984 {published data only}
Nakagawa 2010 {published data only}
  • Nakagawa T, Sakamoto T, Hiraumi H, Kikkawa YS, Yamamoto N, Hamaguchi K, et al. Topical insulin-like growth factor 1 treatment using gelatin hydrogels for glucocorticoid-resistant sudden sensorineural hearing loss: a prospective clinical trial. BMC Medicine 2010;8:76.
Nickisch 1987 {published data only}
  • Nickisch A, Heinemann M, Gross M. Drug therapy in sensorineural hearing loss in childhood [Medikamentose therapie bei schallenmpfindungs-schwerhorigkeiten im kindesalter]. Laryngologie Rhinologie Otologie 1987;66(12):664-6.
Nosrati-Zarenoe 2007 {published data only}
  • Nosrati-Zarenoe R, Arlinger S, Hultcrantz E. Idiopathic sudden sensorineural hearing loss: results drawn from the Swedish national database. Acta Oto-Laryngologica 2007;127(11):1168-75.
Nosrati-Zarenoe 2010 {published data only}
  • Nosrati-Zarenoe R, Hansson M, Hultcrantz E. Assessment of diagnostic approaches to idiopathic sudden sensorineural hearing loss and their influence on treatment and outcome. Acta Oto-Laryngologica 2010;130:384-91.
Ogawa 2002 {published data only}
  • Ogawa K, Takei S, Inoue Y, Kanzaki J. Effect of prostaglandin E1 on idiopathic sudden sensorineural hearing loss: a double-blinded clinical study. Otology and Neurotology 2002;23:665-8.
Orchi 1998 {published data only}
  • Orchi K, Mitsui M, Watenabe S, Nakashima H, Ohashi T, Kinoshita H, et al. The effects of high dose steroid therapy on sudden deafness. Journal of the Oto-rhino-laryngological Society of Japan 1998;101:1311-5.
Panda 2008 {published data only}
  • Panda NK, Verma RK, Saravanan K. Sudden sensorineural hearing loss: have we got a cure?. Journal of Otolaryngology - Head & Neck Surgery 2008;37:807-12.
Park 2009 {published data only}
  • Park HH, Choi JH, Huh EJ, Lee TH, Nam JK, Kwon JK. Comparison of the effect of high-dose steroid with that of super-high-dose steroid therapy in sudden sensorineural hearing loss. Korean Journal of Otorhinolaryngology - Head and Neck Surgery 2009;52:566-71.
Park 2011 {published data only}
  • Park MK, Lee CK, Park KH, Lee JD, Lee CG, Lee BD. Simultaneous versus subsequent intratympanic dexamethasone for idiopathic sudden sensorineural hearing loss. Otolaryngology - Head and Neck Surgery 2011;145:1016-21.
Peng 2008 {published data only}
  • Peng Y, Xiong S, Cheng Y, Qi YF, Yang Y. Clinical investigation of different routes of administration of dexamethasone on sudden deafness. Lin chuang er bi yan hou tou jing wai ke za zhi [Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery] 2008;22(10):442-5.
Penido 2009 {published data only}
  • Penido NO, Cruz OL, Zanoni A, Inoue DP. Classification and hearing evolution of patients with sudden sensorineural hearing loss. Brazilian Journal of Medical and Biological Research 2009;42:712-6.
Plontke 2009 {published data only}
  • Plontke SK, Lowenheim H, Mertens J, Engel C, Meisner C, Weidner A, et al. Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy. Laryngoscope 2009;119:359-69.
Pyykkö 1997 {published data only}
  • Pyykkö I, Ishizaki H, Peltomaa M. Azathioprine with cortisone in treatment of hearing loss in only hearing ear. Acta Oto-Laryngologica 1997;529:83-5.
Rauch 2011 {published data only}
  • Rauch SD, Halpin CF, Antonelli PJ, Babu S, Carey JP, Gantz BJ, et al. Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial. JAMA 2011;305:2071-9.
Roebuck 2006 {published data only}
Sakata 2010 {published data only}
  • Sakata T, Ueno T, Takase H, Shiraishi K, Nakagawa T. Acute idiopathic sensorineural hearing impairment at frequency exceeding 8 kHz. Acta Oto-laryngologica 2010;130:1141-6.
She 2010 {published data only}
  • She WD, Dai YH, Du XP, Yu CJ, Chen F, Wang JG, et al. Hearing evaluation of intratympanic methylprednisolone perfusion for refractory sudden sensorineural hearing loss. Otolaryngology - Head and Neck Surgery 2010;142:266-71.
Shin 2007 {published data only}
  • Shin SO, Choi YS, Lee JY, Yoo SD. The efficacy of an additional cycle of oral steroids in partially recovered sudden sensorineural hearing loss (SSNHL) after initial oral steroid therapy. Acta Oto-laryngologica. Supplementum 2007;558:49-53.
Shiraishi 1991 {published data only}
Slattery 2005a {published data only}
  • Slattery WH, Fisher LM, Iqbal Z, Friedman RA, Liu N. Intratympanic steroid injection for treatment of idiopathic sudden hearing loss. Otolaryngology - Head & Neck Surgery 2005;133(2):251-9.
Slattery 2005b {published data only}
Suoqiang 2012 {published data only}
  • Suoqiang Z, Ning Y, Guiliang Z, Yuhua Z, He Q. Effect of retreatment on the end-stage sudden deafness. Cell Biochemistry and Biophysics 2012;62:403-6.
Suzuki 2003 {published data only}
  • Suzuki H, Furukawa M, Kumagai M, Takahashi E, Matsuura K, Katori Y, et al. Defibrinogenation therapy for idiopathic sudden sensorineural hearing loss in comparison with high-dose steroid therapy. Acta Oto-laryngologica 2003;123:46-50.
Suzuki 2008 {published data only}
  • Suzuki H, Fujimura T, Shiomori T, Ohbuchi T, Kitamura T, Hashida K, et al. Prostaglandin E1 versus steroid in combination with hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss. Auris, Nasus, Larynx 2008;35(2):192-7.
Suzuki 2012 {published data only}
Tsai 2011 {published data only}
  • Tsai YJ, Liang JG, Wu WB, Ding YF, Chiang RPY, Wu SM. Intratympanic injection with dexamethasone for sudden sensorineural hearing loss. Journal of Laryngology and Otology 2011;125:133-7.
Wang 2012 {published data only}
  • Wang Y-W, Ren J-H, Lu Y-D, Yin T-F, Xie D-H. Evaluation of intratympanic dexamethasone for treatment of refractory sudden sensorineural hearing loss. Journal of Zhejiang University - Science B 2012;13:203-8.
Wilkins 1987 {published data only}
Wu 2011 {published data only}
  • Wu HP, Chou YF, Yu SH, Wang CP, Hsu CJ, Chen PR. Intratympanic steroid injections as a salvage treatment for sudden sensorineural hearing loss: a randomized, double-blind, placebo-controlled study. Otology & Neurotology 2011;32:774-9.
Xenellis 2006 {published data only}
  • Xenellis J, Papadimitriou N, Nikolopoulos T, Maragoudakis P, Segas J,   Tzagaroulakis A, et al. Intratympanic steroid treatment in idiopathic sudden sensorineural hearing loss: a control study. Otolaryngology - Head & Neck Surgery 2006;134(6):940-5.
Yang 2010 {published data only}
  • Yang J, Huang L, Shi J, Li Y, Wu H, Kong W. The effect of intratympanic dexamethasone or methylprednisolone on treatment of sudden sensorineural hearing loss. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010;24:594-7.
Yang 2011 {published data only}
Zadeh 2003 {published data only}
  • Zadeh MH, Storper IS, Spitzer JB. Diagnosis and treatment of sudden-onset sensorineural hearing loss: a study of 51 patients. Otolaryngology - Head and Neck Surgery 2003;128(1):92-8.
Zernotti 2009 {published data only}
  • Zernotti ME, Paoletti OA, Zernotti M, Martinez ME, Roques-Revol M, Prina AC. Intratympanic dexamethasone as therapeutic option in sudden sensorineural hearing loss. Acta Otorrinolaringologica Espanola 2009;60:99-103.
Zhao 2009 {published data only}
  • Zhao H, Zhang TY, Fu YY, Jing JH. Preliminary study on intratympanic dexamethasone injection for management of patients with profound sudden hearing loss. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009;44:297-301.
Zhou 2011 {published data only}
  • Zhou Y, Zheng H, Zhang Q, Campione PA. Early transtympanic steroid injection in patients with 'poor prognosis' idiopathic sensorineural sudden hearing loss. ORL; Journal of Oto-Rhino-Laryngology and Its Related Specialties 2011;73:31-7.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Chalmers 1990
Cole 1988
Eisenman 2000
Gulya 1996
  • Gulya AJ. Sudden sensorineural hearing loss: an otologic emergency. Comprehensive Therapy 1996;22(4):217-21.
Haberkamp 1999
  • Haberkamp TJ, Tanyeri HM. Management of idiopathic sudden sensorineural hearing loss. American Journal of Otology 1999;20:587-92; discussion 593-5.
Handbook 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions 5.0.1 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hughes 1996
  • Hughes GB, Freedman MA, Haberkamp TJ, Guay ME. Sudden sensorineural hearing loss. Otolaryngologic Clinics of North America 1996;29(3):394-405.
Mattox 1989
Plontke 2009a
Shikowitz 1991
Stokroos 1996a
  • Stokroos RJ, Albers FWJ. Therapy of idiopathic sudden sensorineural loss. A review of the literature. Acta Oto-rhino-laryngologica Belgica 1996;50:237-45.
Stokroos 1996b
  • Stokroos RJ, Albers FWJ. The etiology of idiopathic sudden sensorineural loss. A review of the literature. Acta Oto-rhino-laryngologica Belgica 1996;50(1):69-76.
Thurmond 1998
  • Thurmond M, Amedee RG. Sudden sensorineural hearing loss: etiologies and treatments. Journal of the Louisiana State Medical Society 1998;150(5):200-3.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Wei 2006