Intervention Review

Transcutaneous Electrical Nerve Stimulation (TENS) for dementia

  1. Michelle H Cameron1,*,
  2. Edmund Lonergan2,
  3. Helen Lee3

Editorial Group: Cochrane Dementia and Cognitive Improvement Group

Published Online: 21 JUL 2003

Assessed as up-to-date: 4 DEC 2005

DOI: 10.1002/14651858.CD004032

How to Cite

Cameron MH, Lonergan E, Lee H. Transcutaneous Electrical Nerve Stimulation (TENS) for dementia. Cochrane Database of Systematic Reviews 2003, Issue 3. Art. No.: CD004032. DOI: 10.1002/14651858.CD004032.

Author Information

  1. 1

    Portland, Oregon, USA

  2. 2

    Emeryville, CA, USA

  3. 3

    Oxford, Oxfordshire, UK

*Michelle H Cameron, 9351 SW 12th Drive, Portland, Oregon, OR 97219, USA.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 JUL 2003




  1. Top of page
  2. Abstract
  3. Plain language summary
  4. Laički sažetak


Transcutaneous electrical nerve stimulation (TENS) is the application of an electrical current through electrodes attached to the skin. The commonest clinical application of TENS is pain control. TENS is also used occasionally for the treatment of a range of neurological and psychiatric conditions including drug and alcohol dependence, headaches, and depression. TENS is rarely used for the treatment of dementia. However, since the early 1990s a number of studies carried out by a group in the Netherlands, and one study carried out by a group in Japan, suggest that TENS applied to the back or head may improve cognition and behaviour in patients with Alzheimer's disease or multi-infarct dementia. It was claimed that applying TENS could benefit patients with dementia by altering the activity of various neurotransmitters, or by increasing brain activity and thereby retarding neural degeneration and stimulating regenerative processes. It is claimed that application of TENS to the head may also alleviate the sleep disorders associated with dementia.


The aim of this review is to determine the effectiveness and safety of transcutaneous electrical nerve stimulation (TENS) in the treatment of dementia. Secondary objectives of this review are to determine whether any effect of treatment of dementia with TENS is influenced by any treatment parameters or patient features, including: the duration of treatment, electrical waveform, current amplitude, pulse duration and frequency and the patient's type or severity of cognitive impairment.

Search methods

The trials were identified from a search of the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group on 5 December 2005 using the terms TENS, transcutaneous, "transcutaneous electrical nerve stimulation", "electric stimulation", or "cranial electrostimulation" or "cranial stimulation". The CDCIG Specialized Register contains records from all major health care databases and many ongoing trials databases and is regularly updated.

Selection criteria

All RCTs in which TENS was used as an intervention for people with dementia were included in this review. This included peripherally applied transcutaneous electrical stimulation as well as transcutaneous electrical stimulation applied to the head (also known as cranial electrical stimulation (CES)).

Data collection and analysis

All randomized controlled trials (RCTs) that fulfilled the inclusion criteria for the review and for which sufficient data were available were included in this meta-analysis. Two reviewers extracted the data from the included trials. All except one of the included trials used similar outcome measures. Data of the same outcome measures were combined for analysis.

Main results

Nine trials were included in the review but only 3 trials could be included in the meta-analysis. Sufficient data to include the other trials in the meta-analysis could not be obtained. From this limited analysis it appears that TENS produced a statistically significant improvement directly after treatment in: delayed recall of 8 words in one trial, face recognition in two trials and motivation in one trial. However, no effect of TENS was found on any of the many other neuropsychological and behavioural measures evaluated either directly after TENS treatment or 6 weeks after treatment was completed.

Authors' conclusions

Although a number of studies suggest that TENS may produce short lived improvements in some neuropsychological or behavioural aspects of dementia, the limited presentation and availability of data from these studies does not allow definite conclusions on the possible benefits of this intervention. Since most of the currently published studies are well designed, although the numbers of subjects in each study is small, analysis of the complete original data from these and/or future studies may allow more definitive conclusions to be drawn.


Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. Laički sažetak

Insufficient data to determine the efficacy of transcutaneous electrical nerve stimulation for dementia

Transcutaneous electrical nerve stimulation (TENS) is rarely used for the treatment of dementia but has been studied in a number of randomized controlled trials. Although the available data suggests TENS may be beneficial for some neuropsychological and/or behavioural aspects of dementia insufficient data was available to these reviewers for definitive conclusions to be drawn.


Laički sažetak

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. Laički sažetak

Nema dovoljno podataka za određivanje učinkovitosti transkutane elektroneurostimulacije kod demencije

Transkutana elektroneurostimulacija (TENS) se rijetko koristi u liječenju demencije, ali je ispitivana u brojnim randomiziranim kontroliranim ispitivanjima. Iako dostupni podaci ukazuju da TENS može biti koristan za neke neuropsihološke i/ili bihevioralne aspekte demencije, autorima ovog Cochrane sustavnog pregleda nije bilo dostupno dovoljno podataka za donošenje konačnih zaključaka.

Bilješke prijevoda

Cochrane Hrvatska
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