Intervention Review

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Pharmacological treatment for psychotic depression

  1. Jaap Wijkstra1,*,
  2. Jeroen Lijmer2,
  3. Huibert Burger3,4,
  4. John Geddes5,
  5. Willem A Nolen4

Editorial Group: Cochrane Depression, Anxiety and Neurosis Group

Published Online: 26 NOV 2013

Assessed as up-to-date: 12 APR 2013

DOI: 10.1002/14651858.CD004044.pub3


How to Cite

Wijkstra J, Lijmer J, Burger H, Geddes J, Nolen WA. Pharmacological treatment for psychotic depression. Cochrane Database of Systematic Reviews 2013, Issue 11. Art. No.: CD004044. DOI: 10.1002/14651858.CD004044.pub3.

Author Information

  1. 1

    UMCU, Department of Psychiatry, Utrecht, Netherlands

  2. 2

    UMCU, Psychiatry, Utrecht, Netherlands

  3. 3

    University Medical Center Groningen, University of Groningen, Department of Epidemiology, Groningen, Netherlands

  4. 4

    University Hospital Groningen, Department of Psychiatry, Groningen, Netherlands

  5. 5

    University of Oxford/Warneford Hospital, Department of Psychiatry, Oxford, UK

*Jaap Wijkstra, Department of Psychiatry, UMCU, B.01.206, Postbox 85500, 3508 GA, Utrecht, Netherlands. J.Wijkstra@umcutrecht.nl.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 26 NOV 2013

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[Figure 1]
Figure 1. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Study flow diagram.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Antidepressant versus placebo, Outcome 1 Clinical response.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Antidepressant versus placebo, Outcome 2 Dropouts.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Antipsychotic versus placebo, Outcome 1 Clinical response.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Antipsychotic versus placebo, Outcome 2 Dropouts.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Antidepressant versus antidepressant, Outcome 1 Clinical response.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Antidepressant versus antidepressant, Outcome 2 Dropouts.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Antidepressant versus antipsychotic, Outcome 1 Clinical response.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Antidepressant versus antipsychotic, Outcome 2 Dropouts.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Antidepressant plus antipsychotic versus placebo, Outcome 1 Clinical response.
[Analysis 5.2]
Analysis 5.2. Comparison 5 Antidepressant plus antipsychotic versus placebo, Outcome 2 Dropouts.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Antidepressant plus antipsychotic versus placebo plus antipsychotic, Outcome 1 Clinical response.
[Analysis 6.2]
Analysis 6.2. Comparison 6 Antidepressant plus antipsychotic versus placebo plus antipsychotic, Outcome 2 Dropouts.
[Analysis 7.1]
Analysis 7.1. Comparison 7 Antidepressant plus antipsychotic versus placebo plus antidepressant, Outcome 1 Clinical response.
[Analysis 7.2]
Analysis 7.2. Comparison 7 Antidepressant plus antipsychotic versus placebo plus antidepressant, Outcome 2 Dropouts.
[Analysis 8.1]
Analysis 8.1. Comparison 8 Antidepressant plus antipsychotic versus placebo plus the same antidepressant, Outcome 1 Clinical response.
[Analysis 8.2]
Analysis 8.2. Comparison 8 Antidepressant plus antipsychotic versus placebo plus the same antidepressant, Outcome 2 Dropouts.