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Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour

  1. Naguesh Naik Gaunekar1,*,
  2. Puvaneswary Raman2,3,
  3. Emily Bain3,
  4. Caroline A Crowther3,4

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 31 OCT 2013

Assessed as up-to-date: 14 JUL 2013

DOI: 10.1002/14651858.CD004071.pub3


How to Cite

Naik Gaunekar N, Raman P, Bain E, Crowther CA. Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD004071. DOI: 10.1002/14651858.CD004071.pub3.

Author Information

  1. 1

    Mater Medical Centre, Suite 28, Mackay, Queensland, Australia

  2. 2

    Women's and Children's Hospital, Women's and Babies' Division, Adelaide, Australia

  3. 3

    The University of Adelaide, ARCH: Australian Research Centre for Health of Women and Babies, The Robinson Institute, Discipline of Obstetrics and Gynaecology, Adelaide, Australia

  4. 4

    The University of Auckland, Liggins Institute, Auckland, New Zealand

*Naguesh Naik Gaunekar, Suite 28, Mater Medical Centre, 76 Willetts Road, Mackay, Queensland, 4740, Australia. nagueshg@yahoo.com.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 31 OCT 2013

SEARCH

[Figure 1]
Figure 1. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Calcium channel blocker versus control, Outcome 1 Preterm birth.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Calcium channel blocker versus control, Outcome 2 Birth within 48 hours of treatment.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Calcium channel blocker versus control, Outcome 3 Perinatal death.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Calcium channel blocker versus control, Outcome 4 Maternal adverse drug reaction causing treatment cessation.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Calcium channel blocker versus control, Outcome 5 Maternal intrauterine infection.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Calcium channel blocker versus control, Outcome 6 Antepartum haemorrhage.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Calcium channel blocker versus control, Outcome 7 Postpartum haemorrhage.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Calcium channel blocker versus control, Outcome 8 Maternal death.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Calcium channel blocker versus control, Outcome 9 Pregnancy prolongation (days).
[Analysis 1.10]
Analysis 1.10. Comparison 1 Calcium channel blocker versus control, Outcome 10 Pregnancy prolongation (days).
[Analysis 1.11]
Analysis 1.11. Comparison 1 Calcium channel blocker versus control, Outcome 11 Birth within seven days of treatment.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Calcium channel blocker versus control, Outcome 12 Gestation at birth.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Calcium channel blocker versus control, Outcome 13 Perinatal mortality.
[Analysis 1.14]
Analysis 1.14. Comparison 1 Calcium channel blocker versus control, Outcome 14 Birthweight (g).
[Analysis 1.15]
Analysis 1.15. Comparison 1 Calcium channel blocker versus control, Outcome 15 Birthweight (g).
[Analysis 1.16]
Analysis 1.16. Comparison 1 Calcium channel blocker versus control, Outcome 16 Small-for-gestational age.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Calcium channel blocker versus control, Outcome 17 Low birthweight.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Calcium channel blocker versus control, Outcome 18 Apgar score less than seven at five minutes.
[Analysis 1.19]
Analysis 1.19. Comparison 1 Calcium channel blocker versus control, Outcome 19 Neonatal sepsis.
[Analysis 1.20]
Analysis 1.20. Comparison 1 Calcium channel blocker versus control, Outcome 20 Neonatal jaundice.
[Analysis 1.21]
Analysis 1.21. Comparison 1 Calcium channel blocker versus control, Outcome 21 Respiratory distress syndrome.
[Analysis 1.22]
Analysis 1.22. Comparison 1 Calcium channel blocker versus control, Outcome 22 Mechanical ventilation.
[Analysis 1.23]
Analysis 1.23. Comparison 1 Calcium channel blocker versus control, Outcome 23 Periventricular leukomalacia.
[Analysis 1.24]
Analysis 1.24. Comparison 1 Calcium channel blocker versus control, Outcome 24 Intraventricular haemorrhage.
[Analysis 1.25]
Analysis 1.25. Comparison 1 Calcium channel blocker versus control, Outcome 25 Chronic lung disease.
[Analysis 1.26]
Analysis 1.26. Comparison 1 Calcium channel blocker versus control, Outcome 26 Necrotising enterocolitis.
[Analysis 1.27]
Analysis 1.27. Comparison 1 Calcium channel blocker versus control, Outcome 27 Composite neonatal morbidity.
[Analysis 1.28]
Analysis 1.28. Comparison 1 Calcium channel blocker versus control, Outcome 28 Neonatal intensive care unit admission.
[Analysis 1.29]
Analysis 1.29. Comparison 1 Calcium channel blocker versus control, Outcome 29 Maternal admission to intensive care unit.
[Analysis 1.30]
Analysis 1.30. Comparison 1 Calcium channel blocker versus control, Outcome 30 Maternal readmission for threatened preterm labour.
[Analysis 1.31]
Analysis 1.31. Comparison 1 Calcium channel blocker versus control, Outcome 31 Length of neonatal intensive care unit stay (days).
[Analysis 1.32]
Analysis 1.32. Comparison 1 Calcium channel blocker versus control, Outcome 32 Length of neonatal intensive care unit stay (days).
[Analysis 1.33]
Analysis 1.33. Comparison 1 Calcium channel blocker versus control, Outcome 33 Length of neonatal hospital stay (days).
[Analysis 1.34]
Analysis 1.34. Comparison 1 Calcium channel blocker versus control, Outcome 34 Length of neonatal hospital stay (days).
[Analysis 2.1]
Analysis 2.1. Comparison 2 Calcium channel blocker versus control (subgroups based on control group), Outcome 1 Preterm birth.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Calcium channel blocker versus control (subgroups based on control group), Outcome 2 Birth within 48 hours of treatment.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Calcium channel blocker versus control (subgroups based on control group), Outcome 3 Neonatal death.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Calcium channel blocker versus control (subgroups based on dose), Outcome 1 Preterm birth.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Calcium channel blocker versus control (subgroups based on dose), Outcome 2 Birth within 48 hours of treatment.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Calcium channel blocker versus control (subgroups based on dose), Outcome 3 Neonatal death.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Calcium channel blocker versus control (subgroups based on duration), Outcome 1 Preterm birth.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Calcium channel blocker versus control (subgroups based on duration), Outcome 2 Birth within 48 hours of treatment.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Calcium channel blocker versus control (subgroups based on duration), Outcome 3 Neonatal death.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Calcium channel blocker versus control (higher quality studies), Outcome 1 Preterm birth.
[Analysis 5.2]
Analysis 5.2. Comparison 5 Calcium channel blocker versus control (higher quality studies), Outcome 2 Birth within 48 hours of treatment.
[Analysis 5.3]
Analysis 5.3. Comparison 5 Calcium channel blocker versus control (higher quality studies), Outcome 3 Stillbirth.
[Analysis 5.4]
Analysis 5.4. Comparison 5 Calcium channel blocker versus control (higher quality studies), Outcome 4 Neonatal death.