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Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour

  1. Naguesh Naik Gaunekar1,*,
  2. Puvaneswary Raman2,3,
  3. Emily Bain3,
  4. Caroline A Crowther3,4

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 31 OCT 2013

Assessed as up-to-date: 14 JUL 2013

DOI: 10.1002/14651858.CD004071.pub3


How to Cite

Naik Gaunekar N, Raman P, Bain E, Crowther CA. Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD004071. DOI: 10.1002/14651858.CD004071.pub3.

Author Information

  1. 1

    Mater Medical Centre, Suite 28, Mackay, Queensland, Australia

  2. 2

    Women's and Children's Hospital, Women's and Babies' Division, Adelaide, Australia

  3. 3

    The University of Adelaide, ARCH: Australian Research Centre for Health of Women and Babies, The Robinson Institute, Discipline of Obstetrics and Gynaecology, Adelaide, Australia

  4. 4

    The University of Auckland, Liggins Institute, Auckland, New Zealand

*Naguesh Naik Gaunekar, Suite 28, Mater Medical Centre, 76 Willetts Road, Mackay, Queensland, 4740, Australia. nagueshg@yahoo.com.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 31 OCT 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Carr 1999 {published data only}
Lyell 2008 {published data only}
  • El Sayed YY. Nifedipine for the maintenance tocolysis of preterm labor: comparison to placebo in a prospective, randomised, double blind trial (ongoing trial). ClinicalTrials.gov (http://clinicaltrials.gov/) (accessed 21 March 2006).
  • Lyell D, Pullen K, Mannan J, Chitkara U, Druzin ML, Caughey A, et al. Maintenance nifedipine vs. placebo: a prospective, double blind trial. American Journal of Obstetrics and Gynecology 2007;197(6 Suppl 1):S6, Abstract no: 10.
  • Lyell DJ, Pullen KM, Mannan J, Chitkara U, Druzin ML, Caughey AB, et al. Maintenance nifedipine tocolysis compared with placebo: a randomized controlled trial. Obstetrics and Gynecology 2008;112(6):1221-6.
Parry 2012 {published data only}
  • Parry E, Roos C. The NIFTY Study. Personal communication 2013.
  • Parry E, Roos C, Stone P, Hayward L, Mol BW, McCowan L. The NIFTY study: a multi-centre randomised double blind placebo controlled trial of nifedipine maintenance tocolysis in fetal fibronectin positive women in threatened preterm labour. American Journal of Obstetrics and Gynecology 2012;206(Suppl 1):S216.
Roos 2013 {published data only}
  • Roos C, Scheepers LH, Bloemenkamp KW, Bolte A, Cornette J, Derks JB, et al. Assessment of perinatal outcome after sustained tocolysis in early labour (APOSTEL-II trial). BMC Pregnancy and Childbirth 2009;9:42.
  • Roos C,  Spaanderman ME,  Schuit E,  Bloemenkamp KW,  Bolte AC,  Cornette J, et al. Effect of maintenance tocolysis with nifedipine in threatened preterm labor on perinatal outcomes: a randomized controlled trial. JAMA 2013;309(1):41-7.
Sayin 2004 {published data only}
Uma 2012 {published data only}
  • Uma M, Ixora KA, Nor Azlin MI, Mahady ZA. Maintenance nifedipine for tocolysis in preterm labour: a prospective randomised controlled trial. BJOG An International Journal of Obstetrics and Gynaecology 2012;119(Suppl):35.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bracero 1991 {published data only}
  • Bracero LA, Leiken E, Kirshenbaum N, Tejani N. Comparison of nifedipine and ritodrine for the treatment of preterm labor. Proceedings of 10th Annual Meeting of the Society of Perinatal Obstetricians; 1990 January 23-27. Houston, Texas, USA, 1990:77.
  • Bracero LA, Leikin E, Kirshenbaum N, Tejani N. Comparison of nifedipine and ritodrine for the treatment of preterm labor. American Journal of Perinatology 1991;8(6):365-9.
El-Sayed 1998 {published data only}
  • El-Sayed YY, Holbrook RH Jr, Gibson R, Chitkara U, Druzin ML, Baba D. Diltiazem for maintenance tocolysis of preterm labor: comparison to nifedipine in a randomized trial. Journal of Maternal-Fetal Medicine 1998;7(5):217-21.
Ferguson 1990 {published data only}
  • Ferguson JE, Dyson DC, Holbrook RH Jr, Schultz T, Stevenson DK. Cardiovascular and metabolic effects associated with nifedipine and ritodrine tocolysis. American Journal of Obstetrics and Gynecology 1989;161(3):788-95.
  • Ferguson JE, Dyson DC, Schultz T, Stevenson DK. A comparison of tocolysis with nifedipine or ritodrine: analysis of efficacy and maternal, fetal and neonatal outcome. American Journal of Obstetrics and Gynecology 1990;163(1 Pt 1):105-11.
  • Ferguson JE, Schultz TE, Stevenson DK. Neonatal bilirubin production after preterm labor tocolysis with nifedipine. Developmental Pharmacology Therapeutics 1989;12(3):113-7.
Garcia-Velasco 1998 {published data only}
  • Garcia-Velasco JA, Gonzalez Gonzalez A. A prospective randomized trial of nifedipine vs. ritodrine in threatened preterm labor. International Journal of Gynaecology and Obstetrics 1998;61:239-44.
Glock 1993 {published data only}
  • Glock JL, Morales WJ. Efficacy and safety of nifedipine versus magnesium sulfate in the management of preterm labor: a randomized study. American Journal of Obstetrics and Gynecology 1993;169(4):960-4.
  • Morales WJ, Glock D. Efficacy and safety of nifedipine vs magnesium sulfate in the management of preterm labor: a randomized study. American Journal of Obstetrics and Gynecology 1993;168:375.
Janky 1990 {published data only}
  • Janky E, Leng JJ, Cormier PH, Salamon R, Meynard J. A randomized study of the treatment of threatened premature labor: nifedipine versus ritodrine. Journal de Gynecologie, Obstetrique et Biologie de la Reproduction (Paris) 1990;19:478-82.
Jannet 1997 {published data only}
  • Jannet D, Abankwa A, Guyard B, Carbonne B, Marpeau L, Milliez J. Nicardipine versus salbutamol in the treatment of premature labor: a prospective randomized study. European Journal of Obstetrics, Gynecology, and Reproductive Biology 1997;73(1):11-6.
Koks 1998 {published data only}
  • Koks CA, Brolmann HA, de Kleine MJ, Manger PA. A randomized comparison of nifedipine and ritodrine for suppression of preterm labor. European Journal of Obstetrics, Gynecology, and Reproductive Biology 1998;77(2):171-6.
Kupferminc 1993 {published data only}
  • Kuperferminc M, Lessing JB, Peyser MR. A comparative, prospective randomized study of nifedipine vs ritodrine for suppressing preterm labor. In: Proceedings of the 39th Annual Meeting of the Society for Gynecologic Investigation; 1992 March 18-21; San Antonio, Texas,1992:335.
  • Kupferminc M, Lessing JB, Yaron Y, Peyser MR. Nifedipine versus ritodrine for suppression of preterm labour. British Journal of Obstetrics and Gynaecology 1993;100(12):1090-4.
Larmon 1999 {published data only}
  • Larmon J, Ross B, May W, Dickerson G, Fischer R, Morrison JC. Oral nicardipine versus intravenous magnesium sulphate for the treatment of preterm labor. American Journal of Obstetrics and Gynecology 1999;181:1432-7.
  • Ross E, Ross B, Dickerson G, Fischer R, Morrison J. Oral nicardipine versus intravenous magnesium sulfate for the treatment of preterm labor. American Journal of Obstetrics and Gynecology 1998;178(1):181.
Papatsonis 1997 {published data only}
  • Papatsonis DN, Kok JH, van Geijn HP, Bleker OP, Ader HJ, Dekker GA. Neonatal effects of nifedipine and ritodrine for preterm labor. Obstetrics and Gynecology 2000;95(4):477-81.
  • Papatsonis DN, van Geijn HP, Ader HJ, Lange FM, Bleker OP, Dekker GA. Nifedipine and ritodrine in the management of preterm labor: a randomized multicenter trial. Obstetrics and Gynecology 1997;90(2):230-4.
  • Papatsonis DN, van Geijn HP, Ader HJ, Lange FM, Bleker OP, Dekker GA. Tocolytic efficacy of nifedipine versus ritodrine: results of a randomized trial. American Journal of Obstetrics and Gynecology 1996;174:306.
  • Papatsonis DNM, Kok JH, Samson JF, Lange FM, Ader HJ, Dekker GA. Neonatal morbidity after randomised trial comparing nifedipine with ritodrine in the management of preterm labour. American Journal of Obstetrics and Gynecology 1997;176(1):S117.
  • Papatsonis DNM, Kok JH, van Geijn HP, Bleker OP, Ader HJ, Dekker GA. Neonatal effects of nifedipine and ritodrine in the management of preterm labour. In: Proceedings of the 5th Annual Congress of the Perinatal Society of Australia and New Zealand; 2001 March 13-16; Canberra, ACT, 2001:100.
  • Papatsonis DNM, van Geijn HP, Dekker GA. Nifedipine as a safe and effective tocolytic agent in the treatment of preterm labor [letter]. American Journal of Obstetrics and Gynecology 2000;183(2):513-4.
  • Papatsonis DNM, van Geijn HP, Kok JH, Ader JH, Dekker GA. Adjuvant use of indomethacin for preterm labor: is it safe to use?. In: Proceedings of the 5th Annual Congress of the Perinatal Society of Australia and New Zealand; 2001 March 13-16; Canberra, ACT, 2001:296.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Agustines 2000
  • Agustines LA, Yin YG, Rumney PJ, Lu MC, Bonebrake R, Asrat T, et al. Outcomes of extremely low-birth-weight infants between 500 and 750 g. American Journal of Obstetrics and Gynecology 2000;182:1113-6.
Berkman 2003
  • Berkman ND, Thorp JM, Lohr KN, Carey TS, Hartmann KE, Gavin NI, et al. Tocolytic treatment for the management of preterm labor: a review of the evidence. American Journal of Obstetrics and Gynecology 2003;188(6):1648-59.
Clarke 2003
  • Clarke M, Oxman AD (editors). Cochrane Reviewers' Handbook 4.2.0 [updated March 2003]. In: The Cochrane Library 2003, Issue 3. Oxford:Update Software.
Clarke 2003a
  • Clarke M, Oxman AD editors. Assessment of Study Quality. Cochrane Reviewers' Handbook 4.1.5. Section 6. In: The Cochrane Library 2003, Issue 2. Oxford: Update Software.
Dodd 2012
Economy 2001
Gyetvai 1999
Han 2013
Harake 1987
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Johnson 1993
King 2003
  • King JF, Flenady VJ, Papatsonis DNM, Dekker GA, Carbonne B. Calcium channel blockers for inhibiting preterm labour. Cochrane Database of Systematic Reviews 2003, Issue 1. [DOI: 10.1002/14651858.CD002255]
Kok 1998
Meirowitz 1999
  • Meirowitz NB, Ananth CV, Smulian JC, Vintzilous AM. Value of maintenance therapy with oral tocolytics: a systematic review. Journal of Maternal-Fetal Medicine 1999;8:177-83.
Meyer 1990
Nanda 2002
  • Nanda K, Cook LA, Gallo MF, Grimes DA. Terbutaline pump maintenance therapy after threatened preterm labor for preventing preterm birth. Cochrane Database of Systematic Reviews 2002, Issue 4. [DOI: 10.1002/14651858.CD003933]
Papatsonis 2009
RevMan 2003
  • The Cochrane Collaboration. Review Manager (RevMan) [Computer program]. Version 4.2 for Windows. Oxford, England: The Cochrane Collaboration, 2003.
RevMan 2012
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Roberts 2006
Sanchez-Ramos 1999

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Gaunekar 2004
  • Gaunekar NN, Crowther CA. Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour. Cochrane Database of Systematic Reviews 2004, Issue 3. [DOI: 10.1002/14651858.CD004071.pub2]