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Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes

  1. Susan J McDonald1,*,
  2. Philippa Middleton2,
  3. Therese Dowswell3,
  4. Peter S Morris4

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 11 JUL 2013

Assessed as up-to-date: 14 MAR 2013

DOI: 10.1002/14651858.CD004074.pub3


How to Cite

McDonald SJ, Middleton P, Dowswell T, Morris PS. Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes. Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD004074. DOI: 10.1002/14651858.CD004074.pub3.

Author Information

  1. 1

    La Trobe University/Mercy Hospital for Women, Midwifery Professorial Unit, Melbourne, Victoria, Australia

  2. 2

    The University of Adelaide, ARCH: Australian Research Centre for Health of Women and Babies, The Robinson Institute, Discipline of Obstetrics and Gynaecology, Adelaide, South Australia, Australia

  3. 3

    The University of Liverpool, Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, Liverpool, UK

  4. 4

    Menzies School of Health Research, Division of Child Health, Darwin, Northern Territory, Australia

*Susan J McDonald, Midwifery Professorial Unit, La Trobe University/Mercy Hospital for Women, Level 4, Room 4.071, 163 Studley Road, Heidelberg, Melbourne, Victoria, 3084, Australia. s.mcdonald@latrobe.edu.au. sue.mcdonald@mercy.com.au.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 11 JUL 2013

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[Figure 1]
Figure 1. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Early versus late cord clamping, Outcome 1 Severe PPH/blood loss 1000 mL or more.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Early versus late cord clamping, Outcome 2 Neonatal death.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Early versus late cord clamping, Outcome 3 PPH/blood loss 500 mL or more.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Early versus late cord clamping, Outcome 4 Mean blood loss (mL).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Early versus late cord clamping, Outcome 5 Maternal haemoglobin (g/dL) 24 to 72 hours postpartum.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Early versus late cord clamping, Outcome 6 Need for blood transfusion.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Early versus late cord clamping, Outcome 7 Need for manual removal of placenta.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Early versus late cord clamping, Outcome 8 Length of third stage > 30 mins.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Early versus late cord clamping, Outcome 9 Length of third stage > 60 mins.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Early versus late cord clamping, Outcome 10 Need for therapeutic uterotonics.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Early versus late cord clamping, Outcome 11 Apgar score < 7 at 5 mins.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Early versus late cord clamping, Outcome 12 Any admission to SCN or NICU.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Early versus late cord clamping, Outcome 13 Respiratory distress.
[Analysis 1.14]
Analysis 1.14. Comparison 1 Early versus late cord clamping, Outcome 14 Jaundice requiring phototherapy.
[Analysis 1.15]
Analysis 1.15. Comparison 1 Early versus late cord clamping, Outcome 15 Clinical jaundice.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Early versus late cord clamping, Outcome 16 Polycythaemia.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Early versus late cord clamping, Outcome 17 Cord haemoglobin (g/dL).
[Analysis 1.18]
Analysis 1.18. Comparison 1 Early versus late cord clamping, Outcome 18 Newborn haemoglobin (g/dL).
[Analysis 1.19]
Analysis 1.19. Comparison 1 Early versus late cord clamping, Outcome 19 Infant haemoglobin at 24-48 hours (g/dL).
[Analysis 1.20]
Analysis 1.20. Comparison 1 Early versus late cord clamping, Outcome 20 Infant haemoglobin at 3-6 months (g/dL).
[Analysis 1.21]
Analysis 1.21. Comparison 1 Early versus late cord clamping, Outcome 21 Low infant haemoglobin at 3-6 months.
[Analysis 1.22]
Analysis 1.22. Comparison 1 Early versus late cord clamping, Outcome 22 Infant haematocrit (%).
[Analysis 1.23]
Analysis 1.23. Comparison 1 Early versus late cord clamping, Outcome 23 Low infant haematocrit (< 45% at 6 hours).
[Analysis 1.24]
Analysis 1.24. Comparison 1 Early versus late cord clamping, Outcome 24 Low infant haematocrit (< 45% at 24-48 hours).
[Analysis 1.25]
Analysis 1.25. Comparison 1 Early versus late cord clamping, Outcome 25 Infant iron deficiency at 3-6 months.
[Analysis 1.26]
Analysis 1.26. Comparison 1 Early versus late cord clamping, Outcome 26 Birthweight (g).
[Analysis 1.27]
Analysis 1.27. Comparison 1 Early versus late cord clamping, Outcome 27 Not breastfeeding on discharge (or later).
[Analysis 1.28]
Analysis 1.28. Comparison 1 Early versus late cord clamping, Outcome 28 Neurodevelopment at 4 months.
[Analysis 1.29]
Analysis 1.29. Comparison 1 Early versus late cord clamping, Outcome 29 Symptoms of infection during first 4 months.