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Noninvasive positive-pressure ventilation as a weaning strategy for intubated adults with respiratory failure

  1. Karen EA Burns1,*,
  2. Maureen O Meade2,
  3. Azra Premji3,
  4. Neill KJ Adhikari4

Editorial Group: Cochrane Anaesthesia, Critical and Emergency Care Group

Published Online: 9 DEC 2013

Assessed as up-to-date: 1 MAY 2012

DOI: 10.1002/14651858.CD004127.pub3


How to Cite

Burns KEA, Meade MO, Premji A, Adhikari NKJ. Noninvasive positive-pressure ventilation as a weaning strategy for intubated adults with respiratory failure. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD004127. DOI: 10.1002/14651858.CD004127.pub3.

Author Information

  1. 1

    Keenan Research Centre/Li Ka Shing Knowledge Institute, Interdepartmental Division of Critical Care and the University of Toronto, Toronto, Ontario, Canada

  2. 2

    McMaster University, Department of Clinical Epidemiology and Biostatistics, Hamilton, Ontario, Canada

  3. 3

    The University of Toronto, Toronto, Ontario, Canada

  4. 4

    University of Toronto, and Department of Critical Care Medicine and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Interdepartmental Division of Critical Care, Toronto, Ontario, Canada

*Karen EA Burns, Interdepartmental Division of Critical Care and the University of Toronto, Keenan Research Centre/Li Ka Shing Knowledge Institute, St Michael's Hospital, 30 Bond Street, Rm 4-045 Queen Wing, Toronto, Ontario, M5B 1WB, Canada. BurnsK@smh.ca. burnske2@hotmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 9 DEC 2013

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 3]
Figure 3. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Noninvasive versus invasive weaning, Outcome 1 Mortality.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Noninvasive versus invasive weaning, Outcome 1 Weaning failure.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Noninvasive versus invasive weaning, Outcome 1 Nosocomial pneumonia.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Noninvasive versus invasive weaning, Outcome 1 LOS ICU.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Noninvasive versus invasive weaning, Outcome 1 LOS hospital.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Noninvasive versus invasive weaning, Outcome 1 Average total duration of mechanical ventilatory support.
[Analysis 7.1]
Analysis 7.1. Comparison 7 Noninvasive versus invasive weaning, Outcome 1 Average duration of ventilation related to weaning.
[Analysis 8.1]
Analysis 8.1. Comparison 8 Noninvasive versus invasive weaning, Outcome 1 Duration of endotracheal mechanical ventilation.
[Analysis 9.1]
Analysis 9.1. Comparison 9 Noninvasive versus invasive weaning, Outcome 1 Reintubation.
[Analysis 10.1]
Analysis 10.1. Comparison 10 Noninvasive versus invasive weaning, Outcome 1 Arrhythmia.
[Analysis 11.1]
Analysis 11.1. Comparison 11 Noninvasive versus invasive weaning, Outcome 1 Tracheostomy.
[Analysis 12.1]
Analysis 12.1. Comparison 12 Sensitivity analysis: noninvasive versus invasive weaning, Outcome 1 Mortality excluding quasi-randomized trial.
[Analysis 12.2]
Analysis 12.2. Comparison 12 Sensitivity analysis: noninvasive versus invasive weaning, Outcome 2 Nosocomial pneumonia excluding quasi-randomized trial.
[Analysis 13.1]
Analysis 13.1. Comparison 13 Noninvasive versus invasive weaning, Outcome 1 Mortality greater than or equal to 50% COPD versus less than 50% COPD.
[Analysis 14.1]
Analysis 14.1. Comparison 14 Noninvasive versus invasive weaning, Outcome 1 Weaning failure greater than or equal to 50% COPD.
[Analysis 15.1]
Analysis 15.1. Comparison 15 Noninvasive versus invasive weaning, Outcome 1 Weaning failure.
[Analysis 15.2]
Analysis 15.2. Comparison 15 Noninvasive versus invasive weaning, Outcome 2 Nosocomial pneumonia.
[Analysis 15.3]
Analysis 15.3. Comparison 15 Noninvasive versus invasive weaning, Outcome 3 Average duration of ventilation related to weaning.
[Analysis 15.4]
Analysis 15.4. Comparison 15 Noninvasive versus invasive weaning, Outcome 4 Reintubation.