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Immunoglobulins for preventing hepatitis A

  1. Jian Ping Liu1,*,
  2. Dimitrinka Nikolova2,
  3. Yutong Fei1

Editorial Group: Cochrane Hepato-Biliary Group

Published Online: 15 APR 2009

Assessed as up-to-date: 20 DEC 2008

DOI: 10.1002/14651858.CD004181.pub2


How to Cite

Liu JP, Nikolova D, Fei Y. Immunoglobulins for preventing hepatitis A. Cochrane Database of Systematic Reviews 2009, Issue 2. Art. No.: CD004181. DOI: 10.1002/14651858.CD004181.pub2.

Author Information

  1. 1

    Beijing University of Chinese Medicine, Centre for Evidence-Based Chinese Medicine, Beijing, China

  2. 2

    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Cochrane Hepato-Biliary Group, Copenhagen, Denmark

*Jian Ping Liu, Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China. jianping_l@hotmail.com. jianping@fagmed.uit.no.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 15 APR 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Conrad 1972 {published data only}
  • Anonymous. Prophylactic gamma globulin for prevention of endemic hepatitis. Effects of US gamma globulin upon the incidence of viral hepatitis and other infectious diseases in US Soldiers abroad. Archives of Internal Medicine 1971;128(5):723-38. [MEDLINE: 4107518]
  • Conrad ME. Endemic viral hepatitis in US soldiers: causative factors and the effect of prophylactic gamma globulin. Canadian Medical Association Journal 1972;106:456-60.
  • Conrad ME, Lemon SM. Prevention of endemic icteric viral hepatitis by administration of immune serum gamma globulin. Journal of Infectious Diseases 1987;156(1):56-63.
  • Smetana HF, Smetana FG. Viral hepatitis in United States soldiers stationed in Korea, 1967-1970: prophylactic efficacy of gamma globulin. Bulletin of the New York Academy of Medicine 1976;52(5):535-60. [MEDLINE: 58695]
Gorbunov 1981a {published data only}
  • Gorbunov MA, Sumarokov AA, Zak MR, Iurkuvenas VB, Lelikov VL, Yaroshevskaya YI, et al. [Effectiveness of preseason serum prevention of hepatitis A using different doses of 10% commercial immunoglobulin]. Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii 1981;1(7):103-10.
Gorbunov 1981b {published data only}
  • Gorbunov MA, Sumarokov AA, Zak MR, Jurkuvenas VB, Lelikov VL, Yaroshevskaya YI, et al. [Effectiveness of preseasonal hepatitis A prophylaxis with 10% commercial immunoglobulin used in different doses]. Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii 1981;1(7):103-10.
Gorbunov 1984 {published data only}
  • Gorbunov MA, Sumarokov AA, Iaroshevskaia IIu, Ikoev VN, Khalitova KA. [Influence of the content of antibodies to hepatitis A virus in immunoglobulin preparations on the effectiveness of the immunoglobulin prevention of hepatitis A]. Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii 1984;6:86-9.
Green 1993 {published data only}
  • Green MS, Cohen D, Lerman Y, Sjogren M, Binn LN, Zur S, et al. A trial of the reactogenicity and immunogenicity of an inactivated hepatitis A vaccine. Israel Journal of Medical Science 1994;30(5-6):485-8.
  • Green MS, Cohen D, Lerman Y, Sjogren M, Binn LN, Zur S, et al. Depression of the immune response to an inactivated hepatitis A vaccine administered concomitantly with immune globulin. Journal of Infectious Diseases 1993;168(3):740-3.
Ignatieva 1972 {published data only}
  • Ignatieva GV, Shatrov II, Mastyukova YN, Volokhovich VV, Trushina NE, Brainina RA, et al. Gamma-globulin and albumin efficacy in pre-seasonal prophylaxis of epidemic hepatitis [Russian]. Immunobiologii 1972;49:96-100.
Iurkuvenas 1982 {published data only}
  • Gorbunov MA, Sumarokov AA, Zak MR, Zak MR, Iurkuvenas VB, Lelikov VL. [Effectiveness of preseason serum prevention of hepatitis A using different doses of 10% commercial immunoglobulin]. Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii 1981;7(7):103-10.
  • Iurkuvenas VB, Zak MR, Sangaila IV, Gurchinas SV, Tarbunas SI. [Experience with the use of immunoglobulin prophylaxis of hepatitis A in the Lithuanian SSR. The prophylactic action of different doses of a commercial immunoglobulin depending on the epidemic situation]. Voprosy Virusologii 1982;27(2):243-7.
  • Iurkuvenas VB, Zak MR, Sangaila IV, Gurchinas SV, Tarbunas SI. [Experience with the use of immunoglobulin prophylaxis of hepatitis A in the Lithuanian SSR. The prophylactic action of different doses of a commercial immunoglobulin in a pre-epidemic period]. Voprosy Virusologii 1982;27(2):241-3.
  • Yurkuvenas VB. [A decrease of immunoglobulin prophylactic effect for hepatitis A upon repeated administration of the preparation]. Voprosy Virusologii 1980;25(5):599-600.
Kark 1982a {published data only}
  • Kark JD. Pre-exposure prophylaxis with immune serum globulin for prevention of viral hepatitis in army recruits. Journal of Epidemiology and Community Health 1982;36(3):176-82.
  • Kark JD, Bar-Shany S, Shor S, Merlinski L, Nili E. Serological hepatitis A virus infections and ratio of clinical to serological infections in a controlled trial of pre-exposure prophylaxis with immune serum globulin. Journal of Epidemiology and Community Health 1985;39(2):117-22.
  • Kark JD, Witztum E, Mazkin H, Nili E, Danon YL. The three-year incidence of non-B viral hepatitis morbidity in a controlled trial of pre-exposure immune serum globulin prophylaxis. Infection 1984;12(4):251-5.
Kark 1983 {published data only}
  • Kark JD. Pre-exposure prophylaxis of viral hepatitis with immune serum globulin in an endemic area. Scandinavian Journal of Infectious Diseases 1983;15(1):3-6.
Lerman 1993 {published data only}
  • Lerman Y, Shohat T, Ashkenazi S, Almog R, Heering SL, Shemer J. Efficacy of different doses of immune serum globulin in the prevention of hepatitis A: a three-year prospective study. Clinical Infectious Diseases 1993;17(3):411-4.
Mosley 1968 {published data only}
  • Mosley JW, Reisler DM, Brachott D, Roth D. Comparison of two lots of immune serum globulin for prophylaxis of infectious hepatitis. American Journal of Epidemiology 1968;87(3):539-50.
Shouval 1993a {published data only}
  • Shouval D, Ashur Y, Adler R, Lewis JA, Miller W, Kuter B, et al. Safety, tolerability, and immunogenicity of an inactivated hepatitis A vaccine: effects of single and booster injections, and comparison to administration of immune globulin. Journal of Hepatology 1993;18(Suppl 2):S32-S37.
Victor 2007 {published data only}
  • Victor JC, Monto AS, Surdina TY, Suleimenova SZ, Vaughan G, Nainan OV, Favorov MO, Margolis HS, Bell BP. Hepatitis A vaccine versus immune globulin for postexposure prophylaxis. The New England Journal of Medicine 2007;357(17):1685-94.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Anonymous 1968 {published data only}
  • Anonymous. Assessment of British gammaglobulin in preventing infectious hepatitis. A report to the director of the Public Health Laboratory Service. British Medical Journal 1968;3(5616):451-4. [MEDLINE: 4174401]
Ginsberg 1972 {published data only}
  • Ginsberg AL, Conrad ME, Bancroft WH, Ling CM, Overby LR. Prevention of endemic HAA-positive hepatitis with gamma globulin: use of a simple radioimmune assay to detect HAA. New England Journal of Medicine 1972;286(11):562-6.
Green 1988 {published data only}
Green 1989 {published data only}
  • Green MS, Block C. Apparent effect of immune serum globulin prophylaxis in the military on viral hepatitis incidence in the civilian population in Israel. Journal of Epidemiology and Community Health 1989;43:187-90.
Hadler 1983 {published data only}
Mann 1982 {published data only}
Seeff 1977 {published data only}
  • Seeff LB, Zimmerman HJ, Wright EC, Finkelstein JD, Garcia-Pont P, Greenlee HB, et al. A randomized, double blind controlled trial of the efficacy of immune serum globulin for the prevention of post-transfusion hepatitis. A Veterans Administration Cooperation study. Gastroenterology 1977;72(1):111-21.
Shouval 1993b {published data only}
  • Shouval D, Ashur Y, Adler R, Lewis JA, Armstrong ME, Davide JP, et al. Single and booster dose responses to an inactivated hepatitis A virus vaccine: comparison with immune serum globulin prophylaxis. Vaccine 1993;11(Suppl 1):S9-S14.
Slepushkin 1987 {published data only}
  • Slephushkin AN, Gorbunov MA, Stepanchuk VA, Ikoev VN, Opanasiuk LG. Evaluation of the effectiveness of a specific immunoglobulin against hepatitis A. Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii 1987;4:52-5.
Weiland 1979 {published data only}
Weiland 1981 {published data only}
  • Weiland O, Niklasson, Berg R, Lundbergh P, Tidestrom L. Clinical and subclinical hepatitis A occuring after immunoglobulin prophylaxis among Swedish UN soldiers in Sinai. Scandinavian Journal of Gastroenterology 1981;16:967-72.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
AAPCID 1996
  • American Academy of Pediatrics Committee on Infectious Diseases. Prevention of hepatitis A infections: guidelines for use of hepatitis A vaccine and immune globulin. Pediatrics 1996;98(6 Pt 1):1207-15.
Berge 2000
Bianco 2004
  • Bianco E, De Masi S, Mele A, Jefferson T. Effectiveness of immune globulins in preventing infectious hepatitis and hepatitis A: a systematic review. Digestive and Liver Diseases 2004;36(12):834-42.
Campbell 2004
CDC 1999
  • Centers for Disease Control and Prevention. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). Morbidity and Mortality Weekly Report 1999;48(RR-12):1-37.
CDC 2006
  • CDC. Recommended childhood and adolescent immunization schedule - United States, 2006. MMWR 2006;54(52):Q1-Q4.
Conrad 1987
Dienstag 1999
  • Dienstag JL. Hepatitis A. In: Bircher J, Benhamou JP, McIntyre N, Rizzetto M, Rodes J editor(s). Oxford Textbook of Clinical Hepatology. 2. Vol. 1, Oxford: Oxford University Press, 1999:870-5.
Donner 2002
Egger 1997
Gluud 2008
  • Gluud C, Nikolova D, Klingenberg SL, Whitfield K, Alexakis N, Als-Nielsen B, et al. Cochrane Hepato-Biliary Group. About The Cochrane Collaboration (Cochrane Review Groups (CRGs)) 2008, Issue 1. Art. No.: LIVER.
Halsey 2002
Higgins 2008
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008]. The Cochrane Colloboration, 2008. Available from www.cochrane-handbook.org.
Hollinger 1996
  • Hollinger FB, Ticehurst JR. Hepatitis A virus. In: Fields BN, Knipe DM, Howley PM editor(s). Fields Virology. 3rd Edition. Philadelphia: Lippincott - Raven, 1996:735-82.
ICH-GCP 1997
  • International Conference on Harmonisation Expert Working Group. Code of Federal Regulations & International Conference on Harmonisation Guidelines. 1. Vol. 1, Philadelphia: Parexel/Barnett, 1997.
Kjaergard 2001
Koff 1998
Lemon 1994
  • Lemon SM. Hepatitis A virus. In: Webster RG, Granoff A editor(s). Encyclopedia of Virology. London: Academic Press Ltd, 1994:54.
Lemon 1997
Liu 2002
Melnick 1995
Moher 1998
  • Moher D, Pham B, Jones A, Cook DJ, Jadad AR, Moher M, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?. The Lancet 1998;352:609-13.
Nothdurft 2008
Pedersen 2002
RevMan 2008 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
Royle 2003
  • Royle P, Milne R. Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches. International Journal of Technology Assessment in Health Care 2003;19(4):591-603.
Schulz 1995
Stapleton 1994
  • Stapleton JT, Lemon SM. Hepatitis A and hepatitis E. In: Hoeprich PD, Jordan MC, Ronald AR editor(s). Infectious Diseases. 5th Edition. Philadelphia: Lippincott Co, 1994:790-7.
Stapleton 1995
Tormans 1992
VHPB 1997
  • Viral Hepatitis Prevention Board. News from the VHPB meeting in St. Julians, Malta. Viral Hepatitis. 1997; Vol. 6:1.
Vickers 1998
Werzberger 1992
WHO 2000
  • WHO. Hepatitis A. http://www.who.int/csr/disease/hepatitis/whocdscsredc2007/en/ Accessed 30 January 2009.
Wood 2008
  • Wood L, Egger M, Gluud LL, Schulz KF, Jüni P, Altman GD, et al. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ (Clinical Research Ed.) 2008;336:601-5.
Woodson 1969