Intervention Protocol

Preterm formula milk versus term formula milk for feeding preterm or low birth weight infants

  1. Karen Simmer1,*,
  2. Lisa M Askie2

Editorial Group: Cochrane Neonatal Group

Published Online: 22 APR 2003

Assessed as up-to-date: 11 FEB 2003

DOI: 10.1002/14651858.CD004204


How to Cite

Simmer K, Askie LM. Preterm formula milk versus term formula milk for feeding preterm or low birth weight infants (Protocol). Cochrane Database of Systematic Reviews 2003, Issue 2. Art. No.: CD004204. DOI: 10.1002/14651858.CD004204.

Author Information

  1. 1

    King Edward Memorial Hospital for Women and Princess Margaret Hospital for Children, Neonatal Care Unit, Subiaco, WA, Australia

  2. 2

    University of Sydney, NHMRC Clinical Trials Centre, Camperdown, NSW, Australia

*Karen Simmer, Neonatal Care Unit, King Edward Memorial Hospital for Women and Princess Margaret Hospital for Children, Bagot Road, Subiaco, WA, 6008, Australia. Karen.Simmer@health.wa.gov.au.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 22 APR 2003

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Among low birth weight or preterm infants, does preterm versus term formula lead to fewer children with poor growth and fewer children with adverse neurodevelopment, without significant adverse effects? In separate comparisons, we will examine the effect of preterm vs term formula fed as sole diet, as supplement to human milk, or as either sole diet or supplement to human milk.

As the factors noted below may impact significantly on treatment effects, the following subgroup analyses will be performed:
- birth weight category (extremely LBW, less than or equal to 1000g) (as very small infants are at higher risk of adverse outcomes)
- gestational age (less than 28 weeks) (as very low gestation infants are at higher risk of adverse outcomes)
- male infants (outcomes for males are different from females)
- trials with longer duration of the intervention, i.e. trials continuing the intervention post-discharge from hospital (as preterm infants may not receive their recommended dietary intakes while still in hospital)
- in utero growth retardation (small and appropriate for gestational age infants may have different nutritional requirements. Studies indicating very low birth weight infants will have a higher percentage of small for gestational age infants than the normal populations.)