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Intervention Protocol

Antioxidants for preventing pre-eclampsia

  1. Rumbold Alice,
  2. Duley Lelia,
  3. Crowther Caroline,
  4. Haslam Ross

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 22 APR 2003

DOI: 10.1002/14651858.CD004227

How to Cite

Alice R, Lelia D, Caroline C, Ross H. Antioxidants for preventing pre-eclampsia (Protocol). The Cochrane Database of Systematic Reviews 2003, Issue 2. Art. No.: CD004227. DOI: 10.1002/14651858.CD004227.

Author Information

*Miss Alice Rumbold, Department of Obstetrics and Gynaecology, Adelaide University, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA, 5006, AUSTRALIA.

Publication History

  1. Published Online: 22 APR 2003


This is not the most recent version of the article. View current version (23 JAN 2008)



  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

1. To determine the effectiveness and safety of any antioxidant supplementation during pregnancy on the risk of:
(a) pre-eclampsia;
(b) small for gestational age infants;
(c) stillbirth and neonatal death;
(d) maternal and neonatal morbidity;
(e) long term development of the child;
(f) side effects and adverse events.

Subgroup analyses will test whether any effects on the primary outcomes are influenced by:
(a) whether women are at low/moderate or high risk of pre-eclampsia;
(b) whether women are randomised in the first rather than the second half of pregnancy (before or after 20 weeks' gestation);
(c) the type of antioxidant supplement(s);
(d) the dosage of the antioxidant supplement(s) (above, within or below accepted pharmacological range);
(e) whether women have low or adequate dietary antioxidant(s) intake (where applicable) before trial entry.

2. If antioxidants are effective, to determine which of these agents are best, what is the ideal dose, and to compare antioxidants with other interventions.