Intervention Review

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Strategies to improve adherence and acceptability of hormonal methods of contraception

  1. Vera Halpern1,
  2. Laureen M Lopez1,*,
  3. David A Grimes2,
  4. Laurie L Stockton3,
  5. Maria F Gallo4

Editorial Group: Cochrane Fertility Regulation Group

Published Online: 26 OCT 2013

DOI: 10.1002/14651858.CD004317.pub4

How to Cite

Halpern V, Lopez LM, Grimes DA, Stockton LL, Gallo MF. Strategies to improve adherence and acceptability of hormonal methods of contraception. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD004317. DOI: 10.1002/14651858.CD004317.pub4.

Author Information

  1. 1

    FHI 360, Clinical Sciences, Research Triangle Park, North Carolina, USA

  2. 2

    University of North Carolina, School of Medicine, Obstetrics and Gynecology, Chapel Hill, North Carolina, USA

  3. 3

    FHI360, Health Services Research, Research Triangle Park, North Carolina, USA

  4. 4

    The Ohio State University, Division of Epidemiology, Columbus, Ohio, USA

*Laureen M Lopez, Clinical Sciences, FHI 360, PO Box 13950, Research Triangle Park, North Carolina, NC 27709, USA.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 26 OCT 2013



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Berenson 2012 {published data only}
  • Berenson A B, Rahman M. A randomized controlled study of two educational interventions on adherence with oral contraceptives and condoms. Contraception 2012;86(6):716-24.
  • Berenson AB. Improving Adolescent Adherence to Hormonal Contraception. (accessed 29 Oct 2010). [NCT00584038]
Canto De Cetina 2001 {published data only}
  • Canto De Cetina TE, Canto P, Luna MO. Effect of counseling to improve compliance in Mexican women receiving depot-medroxyprogesterone acetate. Contraception 2001;63(3):143-6.
Castaño 2012 {published data only}
  • Castaño PM, Bynum JY, Andrés R, Lara M, Westhoff C. Effect of daily text messages on oral contraceptive continuation: a randomized controlled trial. Obstetrics and Gynecology 2012;119(1):14-20. [NCT00677703]
  • Hall KS, Westhoff CL, Castaño PM. The impact of an educational text message intervention on young urban women's knowledge of oral contraception. Contraception 2013;87(4):449-54.
Gilliam 2004 {published data only}
Hou 2010 {published data only}
  • Hou MY, Hurwitz S, Kavanagh E, Fortin J, Goldberg AB. Using daily text-message reminders to improve adherence with oral contraceptives. Obstetrics and Gynecology 2010;116(3):633-40. [NCT00733707]
Jay 1984 {published data only}
  • Jay MS, DuRant RH, Shoffitt T, Linder CW, Litt IF. Effect of peer counselors on adolescent compliance in use of oral contraceptives. Pediatrics 1984;73(2):126-31.
Keder 1998 {published data only}
  • Keder LM, Rulin MC, Gruss J. Compliance with depot medroxyprogesterone acetate: a randomized, controlled trial of intensive reminders. American Journal of Obstetrics and Gynecology 1998;179(3 Pt 1):583-5.
Kirby 2010 {published data only}
  • Kirby D, Raine T, Thrush G, Yuen C, Sokoloff A, Potter SC. Impact of an intervention to improve contraceptive use through follow-up phone calls to female adolescent clinic patients. Perspectives on Sexual and Reproductive Health 2010;42(4):251-7. [NCT00230880]
  • Raine TR. Young Woman's Reach Project: Trial of an Intervention to Impact Contraceptive Behavior, Unintended Pregnancy, and Sexually Transmitted Infections (STIs) Among Adolescent Females (REACH). (accessed 10 Dec 2010).
Trent 2013 {published data only}
  • Trent M. Meaningful use of technology to improve health care delivery. (accessed 11 Jul 2013). [NCT01641380]
  • Trent M, Tomaszewski K. Family planning appointment attendance among urban youth: Results from the depotext trial. Journal of Adolescent Health 2013;52(2):S88.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Andolsek 1982 {published and unpublished data}
  • Andolsek L, Pretnar A. Influence of counseling in postabortal contraception. Presented at Reproductive Health Care International Symposium; 1982 Oct 10-15; Maui, Hawaii.
Behboodi 2013 {published and unpublished data}
  • Behboodi Z. The effect of an educational program based on BASNEF model on choosing contraceptive methods in women. (accessed 11 Jul 2013). [IRCT201205289463N2]
Bender 2004 {published data only}
Burnhill 1985 {unpublished data only}
  • Burnhill MS, King E, Koteen E. Impact of counseling on repeated unplanned pregnancy and contraceptive behavior in low SES abortion population. New Brunswick (NJ): Department of Obstetrics and Gynecology, UMDNJ - Rutgers Medical School 1985.
Carneiro 2011 {published data only}
  • Carneiro Gomes Ferreira AL, Impieri Souza A, Evangelista Pessoa R, Braga C. The effectiveness of contraceptive counseling for women in the postabortion period: an intervention study. Contraception 2011, issue 4:377-83.
  • Ferreiro AL. Contraceptive Counseling Following an Abortion (APA). (accessed 29 Oct 2010). [NCT00756314]
Gilliam 2010 {published data only}
  • Gilliam M L, Neustadt A, Kozloski M, Mistretta S, Tilmon S, Godfrey E. Adherence and acceptability of the contraceptive ring compared with the pill among students: a randomized controlled trial. Obstetrics and Gynecology 2010;115(3):503-10.
  • Hughey A B, Neustadt A B, Mistretta S Q, Tilmon S J, Gilliam M L. Daily context matters: predictors of missed oral contraceptive pills among college and graduate students. American Journal of Obstetrics and Gynecology 2010;203(4):323 e1-7.
Langston 2010 {published data only}
  • Langston AM, Rosario L, Westhoff CL. Structured contraceptive counseling--a randomized controlled trial. Patient Education and Counseling. 2010/09/28 2010; Vol. 81, issue 3:362-7.
  • Langston AM, Rosario LY, Westhoff CL. Structured contraceptive counseling: a randomized controlled trial [abstract]. Contraception 2010;82(2):188-9.
  • Westhoff C. Randomized controlled trial of structured contraceptive counseling in adult women. (accessed 08 Jul 2013). [NCT00746993]
  • World Health Organization. Decision-making tool for family planning clients and providers. (accessed 08 Jan 2012).
Madden 2013 {published data only}
  • Madden T, Mullersman JL, Omvig KJ, Secura GM, Peipert JF. Structured contraceptive counseling provided by the Contraceptive CHOICE Project. Contraception 88;2:243-9.
Metson 1991 {published data only}
  • Metson D, Kassianos GC, Norman DP, Moriarty JMA. Effect of information leaflets on long term recall - useful or useless?. British Journal of Family Planning 1991;17(1):21-3.
Roye 2007 {published data only}
  • Roye C, Perlmutter Silverman P, Krauss B. A brief, low-cost, theory-based intervention to promote dual method use by black and Latina female adolescents: a randomized clinical trial. Health Education & Behavior 2007;34(4):608-21.
  • Roye CF, Hudson M. Developing a culturally appropriate video to promote dual-method use by urban teens: rationale and methodology. AIDS Education and Prevention 2003;15(2):148-58.
Schunmann 2006 {published data only}
  • Schunmann C, Glasier A. Specialist contraceptive counselling and provision after termination of pregnancy improves uptake of long-acting methods but does not prevent repeat abortion: a randomized trial. Human Reproduction 2006;21(9):2296-303.
Schwandt 2013 {published data only}
  • Schwandt HM, Creanga AA, Danso KA, Adanu RM, Agbenyega T, Hindin MJ. Group versus individual family planning counseling in Ghana: a randomized, noninferiority trial. Contraception 2013;88(2):281-8.
Schwarz 2008 {published data only}
  • Schwarz EB, Gerbert B, Gonzales R. Computer-assisted provision of emergency contraception a randomized controlled trial. Journal of General Internal Medicine 2008;23(6):794-9.
Westhoff 2010 {published data only}
  • Langston AM, Rosario LY, Westhoff CL. Structured contraceptive counseling: a randomized controlled trial [abstract]. Contraception 2010;82(2):188-9.
  • Westhoff C. Randomized Controlled Trial of Structured Contraceptive Counseling in Adult Women. (accessed 14 Oct 2010).
Zhu 2009 {published data only}
  • Zhu JL, Zhang W-H, Cheng Y, Xu J, Xu X, Gibson D, et al. Impact of post-abortion family planning services on contraceptive use and abortion rate among young women in China: a cluster randomised trial. European Journal of Contraception and Reproductive Health Care 2009;14(1):46-54.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Smith 2013 {published data only}
  • Smith CGJ. Mobile technology for improved family planning. (accessed 11 Jul 2013). [NCT01823861]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
ARHP 2004
  • Association of Reproductive Health Professionals. Periodic well-woman visit: individualized contraceptive care. ARHP Clinical Proceedings 2004; Vol. May.
Bartz 2011
  • Bartz D, Goldberg AB. Injectable contraceptives. In: Hatcher RA, Trussell J, Nelson AL, Cates W, Kowal D, Pollicar MS editor(s). Contraceptive Technology. 20th Edition. New York: Ardent Media, Inc., 2011:209-36.
Blanc 2002
Davie 1996
  • Davie JE, Walling MR, Mansour DJ, Bromham D, Kishen M, Fowler P. Impact of patient counseling on acceptance of the levonorgestrel implant contraceptive in the United Kingdom. Clinical Therapy 1996;18(1):150-9.
Diaz 2000
  • Diaz J, Bahamondes L, Monteiro I, Petta C, Hildalgo MM, Arce XE. Acceptability and performance of the levonorgestrel-releasing intrauterine system (Mirena) in Campinas, Brazil. Contraception 2000;62(2):59-61.
Dieben 2002
Fleming 1998
Gallo 2013
Gaudet 2004
Glasier 2002
Hall 1997
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  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from John Wiley & Sons, Ltd, (accessed 24 October 2012).
Jain 1989
Jones 2012
  • Jones J, Mosher W, Daniels K. Current contraceptive use in the United States, 2006-2012, and changes in patterns of use since 1995. National health statistics reports; no 60. Hyattsville, MD (USA): National Center for Health Statistics, 2012.
Lei 1996
  • Lei ZW, Wu SC, Garceau RJ, Jiang S, Yang QZ, Wang WL, et al. Effect of pretreatment counseling on discontinuation rates in Chinese women given depo-medroxyprogesterone acetate for contraception. Contraception 1996;53(6):357-61.
Leite 2007
  • Leite IC, Gupta N. Assessing regional differences in contraceptive discontinuation, failure and switching in Brazil. Reproductive Health 2007;4:6.
Little 1998
  • Little P, Griffin S, Kelly J, Dickson N, Sadler C. Effect of educational leaflets and questions on knowledge of contraception in women taking the combined contraceptive pill: randomised controlled trial. British Medical Journal 1998;316(7149):1948-52.
Murphy 2008
  • Murphy PA, Brixner D. Hormonal contraceptive discontinuation patterns according to formulation: investigation of associations in an administrative claims database. Contraception 2008;77(4):257-63.
  • National Collaborating Centre for Women’s and Children’s Health. Long-acting Reversible Contraception: The Effective and Appropriate Use of Long-Acting Reversible Contraception. London: RCOG Press, 2005. (NICE Clinical Guidelines, No. 30). []
Nelson 2008
  • Nelson AL, Westhoff C, Schnare SM. Real-world patterns of prescription refills for branded hormonal contraceptives: a reflection of contraceptive discontinuation. Obstetrics and Gynecology 2008; Vol. 112, issue 4:782-7.
Robinson 2002
  • Robinson KA, Dickersin K. Development of a highly sensitive search strategy for the retrieval of reports of controlled trials using PubMed. International Journal of Epidemiology 2002;31(1):150-3.
Rosenberg 1995
  • Rosenberg MJ, Waugh MS, Long S. Unintended pregnancies and use, misuse, and discontinuation of oral contraceptives. Journal of Reproductive Medicine 1995;40(5):355-60.
Rosenberg 1998
Rosenberg 1999
Rudy 2003
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Silberstein 1966
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Stuart 2009
Trussell 2011
UN 2011
  • United Nations, Department of Economic and Social Affairs. World Contraceptive Use - 2011. (accessed 21 Feb 2013).
Westhoff 2007
  • Westhoff C, Heartwell S, Edwards S, Zieman M, Cushman L, Robilotto C, et al. Initiation of oral contraceptives using a quick start compared with a conventional start: a randomized controlled trial. Obstetrics and Gynecology 2007; Vol. 109, issue 6:1270-6.
White 2011
  • White KO, Westhoff C. The effect of pack supply on oral contraceptive pill continuation: a randomized controlled trial. Obstetrics and Gynecology 2011; Vol. 118, issue 3:615-22.