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Oral versus intravenous rehydration for treating dehydration due to gastroenteritis in children

  1. Lisa Hartling1,
  2. Steven Bellemare2,
  3. Natasha Wiebe3,
  4. Kelly F Russell4,
  5. Terry P Klassen5,
  6. William Raine Craig6,*

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 19 JUL 2006

Assessed as up-to-date: 28 MAR 2006

DOI: 10.1002/14651858.CD004390.pub2


How to Cite

Hartling L, Bellemare S, Wiebe N, Russell KF, Klassen TP, Craig WR. Oral versus intravenous rehydration for treating dehydration due to gastroenteritis in children. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD004390. DOI: 10.1002/14651858.CD004390.pub2.

Author Information

  1. 1

    University of Alberta, Department of Paediatrics, Edmonton, Alberta, Canada

  2. 2

    Dalhousie University, Department of Pediatrics, Halifax, Nova Scotia, Canada

  3. 3

    University of Alberta, Medicine, Edmonton, Alberta, Canada

  4. 4

    Alberta Children's Hospital, Department of Paediatrics, Calgary, Alberta, Canada

  5. 5

    8417 Aberhart Centre One, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

  6. 6

    University of Alberta, Pediatric Emergency, Edmonton, Alberta, Canada

*William Raine Craig, Pediatric Emergency, University of Alberta, 7215 Aberhart Centre 1, 11402 University Ave, Edmonton, Alberta, T6G 2J3, Canada. William.Craig@albertahealthservices.ca.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 19 JUL 2006

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[Figure 1]
Figure 1. Influence plot: meta-analysis using random-effects model (linear form)
[Figure 2]
Figure 2. Galbraith plot
[Figure 3]
Figure 3. Funnel plot for primary outcome (failure to rehydrate) based on fixed-effect model
[Figure 4]
Figure 4. Cumulative plot: failure cumulative by year
[Analysis 1.1]
Analysis 1.1. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 1 Failure to rehydrate (by inpatient/outpatient).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 2 Weight gain (g) at discharge (by inpatient/outpatient).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 3 Per cent weight gain (g) at discharge (by inpatient/outpatient).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 4 Length of hospital stay (days).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 5 Incidences of hyponatremia.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 6 Incidences of hypernatremia (by inpatient/outpatient).
[Analysis 1.7]
Analysis 1.7. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 7 Duration of diarrhea (h) (by inpatient/outpatient).
[Analysis 1.8]
Analysis 1.8. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 8 Total fluid intake (mL/kg) at 6 h (by inpatient/outpatient).
[Analysis 1.9]
Analysis 1.9. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 9 Total fluid intake (mL/kg) at 24 h (by inpatient/outpatient).
[Analysis 1.10]
Analysis 1.10. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 10 Total fluid intake (mL) at 6 h (by inpatient/outpatient).
[Analysis 1.11]
Analysis 1.11. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 11 Complications.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 12 Sodium intake (mmol/kg) at 6 h (by inpatient/outpatient).
[Analysis 1.13]
Analysis 1.13. Comparison 1 Oral rehydration therapy (any solution) versus intravenous therapy, Outcome 13 Sodium levels (mmol/kg) at 24 h (by inpatient/outpatient).
[Analysis 2.1]
Analysis 2.1. Comparison 2 Oral rehydration therapy (any solution) versus intravenous therapy: subgroup analyses, Outcome 1 Failure to rehydrate: review authors' definition.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Oral rehydration therapy (any solution) versus intravenous therapy: subgroup analyses, Outcome 2 Failure to rehydrate: intention-to-treat analysis.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Oral rehydration therapy (any solution) versus intravenous therapy: subgroup analyses, Outcome 3 Failure to rehydrate: by osmolarity.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Oral rehydration therapy (any solution) versus intravenous therapy: subgroup analyses, Outcome 4 Failure to rehydrate: by vomiting.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Oral rehydration therapy (any solution) versus intravenous therapy: subgroup analyses, Outcome 5 Failure to rehydrate: by route.