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Different antibiotic treatments for group A streptococcal pharyngitis

  1. Mieke L van Driel1,2,3,*,
  2. An IM De Sutter3,4,
  3. Natalija Keber5,
  4. Hilde Habraken6,
  5. Thierry Christiaens7

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 30 APR 2013

Assessed as up-to-date: 19 OCT 2012

DOI: 10.1002/14651858.CD004406.pub3


How to Cite

van Driel ML, De Sutter AIM, Keber N, Habraken H, Christiaens T. Different antibiotic treatments for group A streptococcal pharyngitis. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD004406. DOI: 10.1002/14651858.CD004406.pub3.

Author Information

  1. 1

    The University of Queensland, Discipline of General Practice, School of Medicine, Brisbane, Queensland, Australia

  2. 2

    Bond University, Centre for Research in Evidence-Based Practice, Gold Coast, QLD, Australia

  3. 3

    Ghent University, Department of General Practice and Primary Health Care, Ghent, Belgium

  4. 4

    Ghent University, Heymans Institute of Pharmacology, Ghent, Belgium

  5. 5

    University of Ljubljana, Medical Faculty, Ljubljana, Slovenia

  6. 6

    Farmaka, Ghent, Belgium

  7. 7

    Heymans Institute of Pharmacology, Ghent University, Department of General Practice and Primary Health Care and, Ghent, Belgium

*Mieke L van Driel, m.vandriel@uq.edu.au. mieke.vandriel@ugent.be.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 30 APR 2013

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This is not the most recent version of the article. View current version (11 SEP 2016)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Bachand 1991 {published data only}
  • Bachand RT Jr. A comparative study of clarythromycin and penicillin VK in the treatment of outpatients with streptococcal pharyngitis. Journal of Antimicrobial Chemotherapy 1991;27(Suppl A):75-82.
Carbon 1995 {published data only}
  • Carbon C, Chatelin A, Bingen E, Zuck P, Rio Y, Guetat F, et al. A double-blind randomized trial comparing the efficacy and safety of a 5-day course of cefotiam hexetil with that of a 10-day course of penicillin V in adult patients with pharyngitis caused by group A beta-haemolytic streptococci. Journal of Antimicrobial Chemotherapy 1995;35(6):843-54.
Disney 1992a {published data only}
  • Disney FA, Dillon H, Blumer JL, Dudding BA, McLinn SE, Nelson DB, et al. Cephalexin and penicillin in the treatment of group A beta-hemolytic streptococcal throat infections. American Journal of Diseases of Children 1992;146(11):1324-7.
Disney 1992b {published data only}
  • Disney FA, Hanfling MJ, Hausinger SA. Loracarbef (LY163892) vs. penicillin VK in the treatment of streptococcal pharyngitis and tonsillitis. Pediatric Infectious Disease Journal 1992;11(Suppl 8):20-6.
Henness 1982a {published data only}
  • Henness DM. A clinical experience with cefadroxil in upper respiratory tract infection. Journal of Antimicrobial Chemotherapy 1982;10(Suppl B):125-35.
Henness 1982b {published data only}
  • Henness DM. A clinical experience with cefadroxil in upper respiratory tract infection. Journal of Antimicrobial Chemotherapy 1982;10(Suppl B):125-35.
Jackson 1973 {published data only}
Levenstein 1991 {published data only}
  • Levenstein JH. Clarythromycin versus penicillin in the treatment of streptococcal pharyngitis. Journal of Antimicrobial Chemotherapy 1991;27(Suppl A):67-74.
McCarty 1992a {published data only}
  • McCarty J. Loracarbef versus penicillin VK in the treatment of streptococcal pharyngitis and tonsillitis in an adult population. American Journal of Medicine 1992;92(Suppl 6A):74-9.
Muller 1992 {published data only}
Nemeth 1999 {published data only}
  • Nemeth MA, McCarty J, Gooch III WM, Henry D, Keyserling CH, Tack KJ. Comparison of cefdinir and penicillin for the treatment of streptococcal pharyngitis. Clinical Therapeutics 1999;21(11):1873-81.
Norrby 2002 {published data only}
  • Norrby SR, Chang J, Stewart JA, Brumpt I, Conway DP. Relief of symptoms in patients with group A b-hemolytic streptococcus tonsillopharyngitis: comparison between telithromycin and penicillin V. Scandinavian Journal of Infectious Diseases 2003;35(4):223-5.
  • Norrby SR, Rabie WJ, Bacart P, Mueller O, Leroy B, Rangaraju M, et al. Efficacy of short-course therapy with the ketolide telithromycin compared with 10 days of penicillin V for the treatment of pharyngitis/tonsillitis. Scandinavian Journal of Infectious Diseases 2002;33(12):883-90.
O'Doherty 1996 {published data only}
  • O'Doherty B, and the Paediatric Azithromycin Study Group. Azithromycin versus penicillin V in the treatment of paediatric patients with acute streptococcal pharyngitis/tonsillitis. European Journal of Clinical Microbiology and Infectious Diseases 1996;15(9):718-24.
Randolph 1985 {published data only}
Reed 1991 {published data only}
  • Reed BD, Huck W, Zazove P. Treatment of beta-hemolytic streptococcal pharyngitis with cefaclor or penicillin; efficacy and interaction with beta-lactamase-producing organisms in the pharynx. Journal of Family Practice 1991;32(2):138-44.
Stein 1991 {published data only}
  • Stein GE, Christensen S, Mummaw N. Comparative study of clarythromycin and penicillin V in the treatment of streptococcal pharyngitis. European Journal of Clinical Microbiology and Infectious Diseases 1991;10(11):949-53.
Trickett 1973 {published data only}
  • Trickett PC, Dineen P, Mogabgab W. Clinical experience: respiratory tract. Trimethoprim-sulfamethoxazole versus penicillin G in the treatment of group A beta-hemolytic streptococcal pharyngitis and tonsillitis. Journal of Infectious Diseases 1973;128(Suppl):693-5.
Watkins 1997 {published data only}
  • Watkins VS, Smietana M, Conforti PM, Sides GD, Huck W. Comparison of dirithromycin and penicillin for treatment of streptococcal pharyngitis. Antimicrobial Agents and Chemotherapy 1997;41(1):72-5.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Adam 1994 {published data only}
  • Adam D, Hostalek U. Effectiveness and tolerance of cefixime in comparison with penicillin V in bacterial pharyngitis and tonsillitis in children. Cefixime Study Group. Klinische Padiatrie 1994;206(1):26-9.
Adam 1995 {published data only}
  • Adam D, Hostalek U, Troster K. 5-day cefixime therapy for bacterial pharyngitis and/or tonsillitis: comparison with 10-day penicillin V therapy. Infection 1995;22(Suppl 2):83-6.
Adam 1996 {published data only}
  • Adam D, Scholz H, and the Pharyngitis Study Group. Five days of erythromycin estolate versus ten days of penicillin V in the treatment of group A Streptococcal tonsillopharyngitis in children. European Journal of Clinical Microbiology and Infectious Diseases 1996;15(9):712-7.
Adam 2000a {published data only}
  • Adam D, Scholz H, Helmerking M. Comparison of short-course (5 day) cefuroxime axetil with a standard 10 day oral penicillin V regimen in the treatment of tonsillopharyngitis. Journal of Antimicrobial Chemotherapy 2000;45(Suppl):23-30.
Adam 2000b {published data only}
  • Adam D, Scholz H, Helmerking M. Short-course antibiotic treatment of 4782 culture-proven cases of group A streptococcal tonsillopharyngitis and incidence of poststreptococcal sequelae. Journal of Infectious Diseases 2000;182(2):509-16.
Adam 2001 {published data only}
  • Adam D, Scholz H, Helmerking M. Five days ceftibuten versus 10 days penicillin in the treatment of 2099 patients with A-streptococcal tonsillopharyngitis [Fünf Tage Ceftibuten im Vergleich zu zehn Tagen Penicillin V in der Therapie der A-Streptokokken-Tonsillopharyngitis]. Fortschritte der Medizin 2001;119(Suppl 2):63-70.
Aujard 1995 {published data only}
  • Aujard Y, Boucot I, Brahimi N, Chiche D, Bingen E. Comparative efficacy and safety of four-day cefuroxime axetil and ten-day penicillin treatment of group A beta-hemolytic streptococcal pharyngitis in children. Pediatric Infectious Disease Journal 1995;14(4):295-300.
Bottaro 2012 {published data only}
  • Bottaro G, Biasci P, Giudice MLO, Mele G, Montanari G, Napoleone E, et al. 5 days cefaclor vs. 10 days amoxicillin/clavulanate in the treatment of childhood streptococcal pharyngitis. Data from a randomized clinical trial. Minerva Pediatrica 2012;64(3):341-6.
Breese 1974 {published data only}
  • Breese BB, Disney FA, Talpey WB, Green JL. Treatment of Streptococcal pharyngitis with amoxicillin. Journal of Infectious Diseases 1974;129(Suppl):178-80.
Cohen 2002 {published data only}
  • Cohen R, Reinert P, De La Rocque F, Levy C, Boucherat M, Robert M, et al. Comparison of two dosages of azithromycin for three days versus penicillin V for ten days in acute group A streptococcal tonsillopharyngitis. Pediatric Infectious Disease Journal 2002;21:297-303.
Cruz 2011 {published data only}
  • Llerena Santa Cruz ED,  Buñuel Álvarez JC,  Porcar Farrán D,  Solà Pou J,  Fortea Gimeno E,  Cortés Marina RB, et al. Treatment of streptococcal tonsillitis with once-a-day amoxicillin: a meta-analysis. Anales De Pediatria 2011;75(5):298-306.
Davies 1995 {published data only}
  • Davies HD, Low DE, Schwartz B, Scriver S, Fletcher A, O'Rourke K, et al. Evaluation of short-course therapy with cefixime or rifampin for eradication of pharyngeally carried group A Streptococci. Clinical Infectious Diseases 1995;21:1294-6.
Del Mar 2008 {published data only}
  • Del Mar C. Once-daily amoxycillin eradicates group A beta-hemolytic strep as well as penicillin twice a day. Journal of Pediatrics 2008;153(5):725.
De Meyere 1992 {published data only}
  • de Meyere M, Mervielde I, Bogaert M. Use of antibiotics in acute sore throat [Het nut van antibiotica bij acute keelpijn]. Nederlands Tijdschrift Voor Geneeskunde 1992;136(47):2314-7.
Denny 1953 {published data only}
  • Denny FW, Wannamaker LW, Hahn EO. Comparative effects of penicillin, aureomycin and terramycin on streptococcal tonsillitis and pharyngitis. Pediatric Infectious Disease 1953;11:7-14.
Disney 1979 {published data only}
  • Disney FA, Breese BB, Francis AB, Green JL. The use of cefaclor in the treatment of beta-haemolytic streptococcal throat infections in children. Postgraduate Medical Journal 1979;55(Suppl 4):50-2.
Dykhuizen 1996 {published data only}
  • Dykhuizen RS, Golder D, Reid TMS, Gould IM. Phenoxymethyl penicillin versus co-amoxiclav in the treatment of acute streptococcal pharyngitis, and the role of beta-lactamase activity in saliva. Journal of Antimicrobial Chemotherapy 1996;37:133-8.
Esposito 2002 {published data only}
  • Esposito S, Marchisio P, Bosis S, Droghetti R, Mattina R, Principi N, et al. Comparative efficacy and safety of 5-day cefaclor and 10-day amoxycillin treatment of group A streptococcal pharyngitis in children. International Journal of Antimicrobial Agents 2002;20:28-33.
Feder 1999 {published data only}
Gerber 1986 {published data only}
Gerber 1999a {published data only}
  • Gerber MA, Tanz RR, Kabat W, Bell GL, Siddiqui PN, Lerer TJ, et al. Potential mechanisms for failure to eradicate group A streptococci from the pharynx. Pediatrics 1999;104(4):911-7.
Gooch 1993 {published data only}
  • Gooch WM 3rd, McLinn SE, Arnovitz GH, Pichichero ME, Kumar A, Kaplan A, et al. Efficacy of cefuroxime axetil suspension compared with that of penicillin V suspension in children with group A streptococcal pharyngitis. Antimicrobial Agents and Chemotherapy 1993;37(2):159-63.
Granizio 2008 {published data only}
  • Granizio JJ, Gimenez MJ, Barberan J, Coronel J, Gimeno M, Aguilar L. Efficacy of cefditoren in the treatment of upper respiratory tract infections: a pooled analysis of six clinical trials. Revista Espanola de Quimioterapia 2008;21(1):14-21.
Hamill 1993 {published data only}
  • Hamill J. Multicentre evaluation of azithromycin and penicillin V in the treatment of acute streptococcal pharyngitis and tonsillitis in children. Journal of Antimicrobial Chemotherapy 1993;31(Suppl E):89-94.
Haverkorn 1971 {published data only}
  • Haverkorn MJ, Valkenburg HA, Goslings WR. Streptococcal pharyngitis in the general population. I. A controlled study of streptococcal pharyngitis and its complications in the Netherlands. Journal of Infectious Diseases 1971;124(4):339-47.
Holm 1991 {published data only}
  • Holm SE, Roos K, Stromberg A. A randomized study of treatment of streptococcal pharyngotonsillitis with cefadroxil or phenoxymethylpenicillin (penicillin V). Pediatric Infectious Disease Journal 1991;10(Suppl 10):68-71.
Howe 1997 {published data only}
  • Howe RW, Millar MR, Coast J, Whitfield M, Peters TJ, Brookes S. A randomized controlled trial of antibiotics on symptom resolution in patients presenting to their general practitioner with a sore throat. British Journal of General Practice 1997;47:280-4.
Lennon 2008 {published data only}
  • Lennon DR, Farrell E, Martin DR, Stewart JM. Once-daily amoxicillin versus twice-daily penicillin V in group A beta-hemolytic streptococcal pharyngitis. Archives of Disease in Childhood 2008;93(6):474-8.
Matsen 1974 {published data only}
  • Matsen JM, Torstenson O, Siegel SE, Bacaner H. Use of available dosage forms of cephalexin in clinical comparison with phenoxymethyl penicillin and benzathine penicillin in the treatment of streptococcal pharyngitis in children. Antimicrobial Agents and Chemotherapy 1974;6(4):501-6.
McCarty 1992b {published data only}
  • McCarty JM, Renteria A. Treatment of pharyngitis and tonsillitis with cefprozil: review of three multicenter trials. Clinical Infectious Diseases 1992;14(Suppl 2):224-30.
McCarty 1994 {published data only}
  • McCarty JM. Comparative efficacy and safety of cefprozil versus penicillin, cefaclor and erythromycin in the treatment of streptococcal pharyngitis and tonsillitis. European Journal of Clinical Microbiology and Infectious Diseases 1994;13(10):846-50.
McIsaac 2004 {published data only}
Milatovic 1991 {published data only}
  • Milatovic D. Evaluation of cefadroxil, penicillin and erythromycin in the treatment of streptococcal tonsillopharyngitis. Pediatric Infectious Disease Journal 1991;10(Suppl):61-3.
Milatovic 1993 {published data only}
Pacifico 1996 {published data only}
  • Pacifico L, Scopetti F, Ranucci A, Pataracchia M, Savignoni F, Chiesa C. Comparative efficacy and safety of 3-day azithromycin and 10-day penicillin V treatment of group A beta-hemolytic streptococcal pharyngitis in children. Antimicrobial Agents and Chemotherapy 1996;40(4):1005-8.
Perkins 1969 {published data only}
Pichichero 2000 {published data only}
  • Pichichero ME, Gooch WM 3rd. Comparison of cefdinir and penicillin V in the treatment of pediatric streptococcal tonsillopharyngitis. Pediatric Infectious Disease Journal 2000;19(Suppl 12):171-3.
Pichichero 2008 {published data only}
  • Pichichero ME, Casey JR, Block SL, Guttendorf R, Flanner H, Markowitz D, et al. Pharmacodynamic analysis and clinical trial of amoxicillin sprinkle administered once daily for 7 days compared to penicillin v potassium administered four times daily for 10 days in the treatment of tonsillopharyngitis due to streptococcus pyogenes in children. Antimicrobial Agents and Chemotherapy 2008;52(7):2512-20.
Portier 1990 {published data only}
  • Portier H, Chavanet P, Gouyon JB, Guetat F. Five day treatment of pharyngotonsillitis with cefpodoxime proxetil. Journal of Antimicrobial Chemotherapy 1990;26(Suppl E):79-85.
Portier 1994 {published data only}
  • Portier H, Chavanet P, Waldner-Combernoux A, Kisterman JP, Grey PC, Ichou F, et al. Five versus ten days treatment of Streptococcal pharyngotonsillitis: a randomized controlled trial comparing cefpodoxime proxetil and phenoxymethyl penicillin. Scandinavian Journal of Infectious Diseases 1994;26(1):59-66.
Rimoin 2011 {published data only}
  • Rimoin AW, Hoff NA, Fischer Walker CL, Hamza HS, Vince A, Abdel Rahman N, et al. Treatment of streptococcal pharyngitis with once-daily amoxicillin versus intramuscular benzathine penicillin G in low-resource settings: a randomized controlled trial. Clinical Pediatrics 2011;50(6):535-42.
Roos 1997 {published data only}
Sakata 2008 {published data only}
  • Sakata H. Comparative study of 5-day cefcapene-pivoxil and 10-day amoxicillin or cefcapene-pivoxil for treatment of group A streptococcal pharyngitis in children. Journal of Infection & Chemotherapy 2008;14(3):208-12.
Sanofi Aventis 2010 {published and unpublished data}
  • Anon. Efficacy study of pristinamycin versus amoxicillin to treat tonsillitis induced by streptococcus in children. www.clinicaltrials.gov. [: http://clinicaltrials.gov/ct2/show/record/NCT00393744]
Shapera 1973 {published data only}
  • Shapera RM, Hable KA, Matsen JM. Erythromycin therapy twice daily for streptococcal pharyngitis. Controlled comparison with erythromycin or penicillin phenoxymethyl four times daily or penicillin G benzathine. JAMA 1973;226(5):531-5.
Shvartzman 1993 {published data only}
Siegel 1961 {published data only}
  • Siegel AC, Johnson EE, Stollerman GH. Controlled studies of Streptococcal pharyngitis in a pediatric population. New England Journal of Medicine 1961;265(12):559-65.
Standaert 1997 {published data only}
  • Standaert BB, Finney KMA, Taylor MT, Coleman RT, Horowitz CL, Walter SM, et al. Comparison between cefprozil and penicillin to eradicate pharyngeal colonization of group A beta-hemolytic streptococci. Pediatric Infectious Disease Journal 1998;17(1):39-43.
Stillerman 1986 {published data only}
  • Stillerman M. Comparison of oral cephalosporins with penicillin therapy for group A streptococcal pharyngitis. Pediatric Infectious Disease Journal 1986;5(6):649-54.
Tack 1997 {published data only}
  • Tack KJ, Hendrick JA, Rothstein E, Nemeth MA, Keyserling C, Pichichero ME. A study of 5-day treatment for streptococcal pharyngitis in children. Cefdinir Pediatric Study Group. Archives of Pediatric and Adolescent Medicine 1997;151(1):45-9.
Tack 1998 {published data only}
  • Tack KJ, Henry DC, Gooch WM, Brink DN, Keyserling CH, The Cefdinir Pharyngitis Study Group. Five-day cefdinir treatment for streptococcal pharyngitis. Antimicrobial Agents and Chemotherapy 1998;42(5):1073-5.
Uysal 2000 {published data only}
  • Uysal S, Sanack R, Sunbul M. A comparison of the efficacy of cefuroxime axetil and intramuscular benzathine penicillin for treating streptococcal tonsillopharyngitis. Annals of Tropical Paediatrics 2000;20:199-202.
Zwart 2000 {published data only}
  • Zwart S, Sachs APE, Ruijs GJHM, Gubbels JW, Hoes AW, et al. Penicillin for acute sore throat: randomised double blind trial of seven days versus three days treatment or placebo in adults. BMJ 2000;320(7228):150-4.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Pfizer 2011 {published and unpublished data}
  • Pfizer. A multicenter, randomized, double-blind, double-dummy study of azithromycin SR versus amoxicillin for the treatment of strep throat In children. www.clinicaltrials.gov. [: http://clinicaltrials.gov/ct2/show/record/NCT00643149]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Brunton 2006
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Cars 2001
Casey 2004
Cooper 1992
Cooper 2001
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DerSimonian 1986
Gerber 1999b
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Gerber 2009b
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Higgins 2003
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Linder 2001
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Matthys 2007
McIsaac 1998
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Neuner 2003
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Shulman 2004
Snow 2001
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Spinks 2011
van Driel 2009
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Wise 1998