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Oral evening primrose oil and borage oil for eczema

  1. Joel TM Bamford1,*,
  2. Sujoy Ray2,
  3. Alfred Musekiwa3,
  4. Christel van Gool4,
  5. Rosemary Humphreys5,
  6. Edzard Ernst6

Editorial Group: Cochrane Skin Group

Published Online: 30 APR 2013

Assessed as up-to-date: 29 AUG 2012

DOI: 10.1002/14651858.CD004416.pub2


How to Cite

Bamford JTM, Ray S, Musekiwa A, van Gool C, Humphreys R, Ernst E. Oral evening primrose oil and borage oil for eczema. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD004416. DOI: 10.1002/14651858.CD004416.pub2.

Author Information

  1. 1

    University of Minnesota Medical School, Department of Family Medicine and Community Health, Duluth, Minnesota, USA

  2. 2

    St. John's Medical College and Hospital, Department of Psychiatry, Bangalore, Karnataka, India

  3. 3

    University of the Witwatersrand, Wits Reproductive Health and HIV Institute (WRHI), Faculty of Health Sciences, Johannesburg, South Africa

  4. 4

    Maastricht University, Department of Epidemiology, CAPHRI, Maastricht, Netherlands

  5. 5

    The University of Nottingham, c/o Cochrane Skin Group, Nottingham, UK

  6. 6

    Peninsula Medical School, University of Exeter, Complementary Medicine Department, Exeter, UK

*Joel TM Bamford, PO 3247, Duluth, Minnesota, 55803-3247, USA. JoelTMBamford@icloud.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 30 APR 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bahmer 1992 {published data only (unpublished sought but not used)}
  • Bahmer FA, Schafer J. Treatment of Atopic Dermatitis with Borage Seed Oil (Glandol) - a Time Series Analysis Study [Die Behandlung der atopischen Dermatitis mit Borretschsamen-Ol (Glandol)--eine zeitreihenanalytische Studie]. Kinderarztliche Praxis 1992;60(7):199-202. [MEDLINE: 1434338]
Bamford 1985 {published and unpublished data}
  • Bamford JT, Gibson RW, Renier CM. Atopic eczema unresponsive to evening primrose oil (linoleic and gammma-linolenic acids). Journal of the American Academy of Dermatology 1985;13(6):959-65. [PUBMED: 3908514]
Berth-Jones 1993 {published data only}
Biagi 1994 {published data only (unpublished sought but not used)}
  • Biagi PL, Bordoni A, Hrelia S, Celadon M, Ricci GP, Cannella V, et al. The effect of gamma-linolenic acid on clinical status, red cell fatty acid composition and membrane microviscosity in infants with atopic dermatitis. Drugs Under Experimental & Clinical Research 1994;20(2):77-84. [MEDLINE: 7924900]
Borrek 1997 {published data only}
  • Borrek S, Hildebrandt A, Forster J. Gamma-linolenic-acid-rich borage seed oil capsules in children with atopic dermatitis. A placebo-controlled double-blind study [Gammalinolensaure-reiche Borretschsamenol-Kapseln bei Kindern mit Atopischer Dermatitis. Eine placebo-kontrollierte Doppelblind-Studie]. Klinische Padiatrie 1997;209(3):100-4.
Buslau 1996 {published data only}
  • Buslau M, Thaci D. Atopic dermatitis: Borage oil for systemic therapy [Atopische Dermatitis: Borretschol zur systemischen Therapie]. Zeitschrift fur Dermatologie 1996;182(3):131-6.
Don 2003 {published data only (unpublished sought but not used)}
  • Don M, Melli P, Braida F, Comici A, Barbi E, Spano C, et al. Efficacy of essential fatty acids in the treatment of atopic dermatitis and correlations of their changes with clinical response [Efficacia degli acidi grassi essenziali nel trattamento della dermatite atopica e correlazione de; loro cambiamenti con la risposta clinica]. Italian Journal of Pediatrics 2003;29(6):427-32.
Finlay 2001 {unpublished data only}
  • Finlay AY, Marks R, Wilson AM, Huntley C. Epogam in Children with Atopic Eczema. Pharmacia (Formerly Searle Division of Monsanto) 2001:1-473.
France 1988 {unpublished data only}
  • France, et al. Epogam in Severe Atopic Eczema. Pharmacia 2001(18 October). [ISN 880002/3/4/24/25/128/130/890141]
Fraser 2001 {unpublished data only}
  • Fraser. Efamol in Atopic Eczema. Pharmacia 2001 (22 October). [ISSN 86004/5/6/7]
Harper 1990 {unpublished data only}
  • Harper J statician authors: Jaderberg M, Wilson A. Efamol in Moderate to Severe Atopic Eczema. Pharmacia 2001. [SN 890136/7]
Heddle 1990 {unpublished data only}
  • Heddle RJ, Forsyth K, Gordon LA, TAO BK, Gibson RA. Oral Evening Primrose Oil (EPO) in Atopic Eczema. Pharmacia 2001. [ISN 910033]
Hederos 1996 {published data only}
Henz 1999 {published data only}
Kenicer 2001 {unpublished data only}
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Kovar 1992 {unpublished data only}
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Lovell 1981 {published and unpublished data}
MacKie Adult 1990 {unpublished data only}
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MacKie Child 1990 {published data only}
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MacLeod 2001 {unpublished data only}
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Schalin-Karrila 1987 {published data only}
Senapati 2008 {published data only}
  • Senapati S, Banerjee S, Gangopadhyay DN. Evening primrose oil is effective in atopic dermatitis: A randomized placebo-controlled trial. Indian Journal of Dermatology, Venereology and Leprology 2008;74(5):447-52. [PUBMED: 19052401]
Takwale 2003 {published data only}
  • Takwale A, Tan E, Agarwal S, Barclay G, Ahmed I, Hotchkiss K, et al. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomized, double blind, placebo controlled, parallel group trial. BMJ 2003;327(7428):1385. [PUBMED: 14670885]
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Wishart 1992 {unpublished data only}
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Wright 1982 {published data only (unpublished sought but not used)}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Biagi 1988 {published data only (unpublished sought but not used)}
  • Biagi PL, Bordoni A, Masi M, Ricci G, Fanelli C, Patrizi A, et al. A long-term study on the use of evening primrose oil (Efamol) in atopic children. Drugs Under Experimental & Clinical Research 1988;14(4):285-90. [MEDLINE: 3048952]
Bordoni 1988 {published data only}
  • Bordoni A, Biagi PL, Masi M, Ricci G, Fanelli C, Patrizi A, et al. Evening primrose oil (Efamol) in the treatment of children with atopic eczema. Drugs Under Experimental & Clinical Research 1988;14(4):291-7. [PUBMED: 3048953]
Coskery 1988 {published data only (unpublished sought but not used)}
  • Coskery G, Cowley N, Allen R. The Effect of Dietary Supplementation with Evening Primrose Oil on Skin Surface Texture in Atopic Dermatitis, A quantitative method of assessment. [Abstract 216]. The 18th Annual Meeting of the European Society for Dermatologic Research 19-22 June 1988, Munich, Germany. Journal of Investigative Dermatology 1988; Vol. 91, issue 4:413.
Courage 1991 {published data only}
  • Courage B, Nissen HP, Wehrmann W, Biltz H. Influence of polyunsaturated Fatty Acids on the Plasma Catecholamines of Patients with Atopic Eczema [Veranderungen des Katecholaminspiegels bei Neurodermatitis - Beeinflussung durch ungesattigte Fettsauren]. H+G Zeitschrift fur Hautkrankheiten 1991;66(6):509-10. [EMBASE: 1991249008]
Guenther 1987 {published data only (unpublished sought but not used)}
  • Guenther L, Wexler D. Efamol in the treatment of atopic dermatitis. Journal of the American Academy of Dermatology 1987; Vol. 17, issue 5 Pt 1:860.
Melnick 1995 {published data only}
  • Melnik BC, Bahmer FA. Treatment of Atopic Dermatitis with Glandol and Epoleum - A Comparative Study [Die behandlung des atopischen ekzems mit glandol und epoleum - eine vergleichende studie]. Aktuelle Dermatologie 1995;21(7):215-9.
NCT00878670 {unpublished data only}
  • NCT00878670. Investigation of Efficacy and Safety of EPOGAM. clinicaltrials.gov/ct2/show/NCT00878670 (accessed 16 December 2012).
Swapan 2008 {published data only}
  • Swapan S, Banerjee S, Gangopadhyay DN. Evening primrose oil is effective in atopic dermatitis: A randomized placebo-controlled trial. Indian Journal of Dermatology, Venereology & Leprology 2008;74(5):447-52. [PUBMED: 19052401]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
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Dove 1999
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Draelos 2008
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