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Delayed antibiotics for respiratory infections

  1. Geoffrey KP Spurling1,*,
  2. Chris B Del Mar2,
  3. Liz Dooley3,
  4. Ruth Foxlee4,
  5. Rebecca Farley1

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 30 APR 2013

Assessed as up-to-date: 28 FEB 2013

DOI: 10.1002/14651858.CD004417.pub4


How to Cite

Spurling GKP, Del Mar CB, Dooley L, Foxlee R, Farley R. Delayed antibiotics for respiratory infections. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD004417. DOI: 10.1002/14651858.CD004417.pub4.

Author Information

  1. 1

    University of Queensland, Discipline of General Practice, Herston, Queensland, Australia

  2. 2

    Bond University, Centre for Research in Evidence-Based Practice (CREBP), Gold Coast, Queensland, Australia

  3. 3

    Bond University, Faculty of Health Sciences and Medicine, Gold Coast, Queensland, Australia

  4. 4

    University of York, Department of Health Sciences, York, UK

*Geoffrey KP Spurling, Discipline of General Practice, University of Queensland, Level 8, Health Sciences Building 16/910, Royal Brisbane and Women's Hospital, Herston, Queensland, 4029, Australia. g.spurling@uq.edu.au. geoffspurling@optusnet.com.au.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 30 APR 2013

SEARCH

[Figure 1]
Figure 1. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 2]
Figure 2. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Sore throat - pain; delayed versus immediate antibiotics, Outcome 1 Pain on day 3.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Sore throat - pain; delayed versus immediate antibiotics, Outcome 2 Pain severity on day 3.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Sore throat - malaise; delayed versus immediate antibiotics, Outcome 1 Malaise on day 3.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Sore throat - malaise; delayed versus immediate antibiotics, Outcome 2 Malaise severity.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Sore throat - fever; delayed versus immediate antibiotics, Outcome 1 Fever severity on day 3.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Sore throat - fever; delayed versus immediate antibiotics, Outcome 2 Fever severity on day 1.
[Analysis 4.1]
Analysis 4.1. Comparison 4 AOM - pain; delayed versus immediate antibiotics, Outcome 1 Pain on day 3.
[Analysis 4.2]
Analysis 4.2. Comparison 4 AOM - pain; delayed versus immediate antibiotics, Outcome 2 Pain on days 4 to 6.
[Analysis 4.3]
Analysis 4.3. Comparison 4 AOM - pain; delayed versus immediate antibiotics, Outcome 3 Pain on day 7.
[Analysis 4.4]
Analysis 4.4. Comparison 4 AOM - pain; delayed versus immediate antibiotics, Outcome 4 Pain severity on day 3.
[Analysis 4.5]
Analysis 4.5. Comparison 4 AOM - pain; delayed versus immediate antibiotics, Outcome 5 Pain severity on day 7.
[Analysis 5.1]
Analysis 5.1. Comparison 5 AOM - malaise; delayed versus immediate antibiotics, Outcome 1 Malaise on day 3.
[Analysis 5.2]
Analysis 5.2. Comparison 5 AOM - malaise; delayed versus immediate antibiotics, Outcome 2 Malaise severity on day 3.
[Analysis 5.3]
Analysis 5.3. Comparison 5 AOM - malaise; delayed versus immediate antibiotics, Outcome 3 Malaise severity on day 7.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Supplementary medicine consumption; delayed versus immediate antibiotics, Outcome 1 Spoons of paracetamol/day.
[Analysis 6.2]
Analysis 6.2. Comparison 6 Supplementary medicine consumption; delayed versus immediate antibiotics, Outcome 2 Use of paracetamol and ibuprofen.
[Analysis 7.1]
Analysis 7.1. Comparison 7 AOM - fever; delayed versus immediate antibiotics, Outcome 1 Fever Days 4 to 6.
[Analysis 8.1]
Analysis 8.1. Comparison 8 AOM - pain; delayed versus no antibiotics, Outcome 1 Otitis media pain on Day 3 delayed versus none.
[Analysis 9.1]
Analysis 9.1. Comparison 9 AOM - fever; delayed versus no antibiotics, Outcome 1 Otitis media number of patients with fever on day 3 delayed versus none.
[Analysis 10.1]
Analysis 10.1. Comparison 10 Common cold - pain; delayed versus immediate antibiotics, Outcome 1 Pain on day 3.
[Analysis 10.2]
Analysis 10.2. Comparison 10 Common cold - pain; delayed versus immediate antibiotics, Outcome 2 Pain on day 7.
[Analysis 11.1]
Analysis 11.1. Comparison 11 Common cold - fever; delayed versus immediate antibiotics, Outcome 1 Fever on day 3.
[Analysis 11.2]
Analysis 11.2. Comparison 11 Common cold - fever; delayed versus immediate antibiotics, Outcome 2 Fever on day 7.
[Analysis 11.3]
Analysis 11.3. Comparison 11 Common cold - fever; delayed versus immediate antibiotics, Outcome 3 Fever severity on day 1.
[Analysis 11.4]
Analysis 11.4. Comparison 11 Common cold - fever; delayed versus immediate antibiotics, Outcome 4 Fever severity on day 3.
[Analysis 11.5]
Analysis 11.5. Comparison 11 Common cold - fever; delayed versus immediate antibiotics, Outcome 5 Fever severity on day 7.
[Analysis 12.1]
Analysis 12.1. Comparison 12 Common cold - cough; delayed versus immediate antibiotics, Outcome 1 Cough on day 3.
[Analysis 12.2]
Analysis 12.2. Comparison 12 Common cold - cough; delayed versus immediate antibiotics, Outcome 2 Cough on day 7.
[Analysis 13.1]
Analysis 13.1. Comparison 13 Antibiotic use: delayed versus immediate antibiotics, Outcome 1 Antibiotic use: delayed versus immediate antibiotics.
[Analysis 14.1]
Analysis 14.1. Comparison 14 Antibiotic use: delayed versus no antibiotics, Outcome 1 Antibiotic use: delayed versus no antibiotics.
[Analysis 15.1]
Analysis 15.1. Comparison 15 Patient satisfaction: delayed versus immediate antibiotics, Outcome 1 Patient satisfaction: delayed versus immediate antibiotics.
[Analysis 16.1]
Analysis 16.1. Comparison 16 Patient satisfaction: delayed versus no antibiotics, Outcome 1 Patient satisfaction: delayed versus no antibiotics.
[Analysis 17.1]
Analysis 17.1. Comparison 17 Adverse events: delayed versus immediate antibiotics, Outcome 1 Vomiting.
[Analysis 17.2]
Analysis 17.2. Comparison 17 Adverse events: delayed versus immediate antibiotics, Outcome 2 Diarrhoea.
[Analysis 17.3]
Analysis 17.3. Comparison 17 Adverse events: delayed versus immediate antibiotics, Outcome 3 Rash.
[Analysis 17.4]
Analysis 17.4. Comparison 17 Adverse events: delayed versus immediate antibiotics, Outcome 4 Stomach ache.
[Analysis 18.1]
Analysis 18.1. Comparison 18 Adverse events: delayed versus no antibiotics, Outcome 1 Vomiting.
[Analysis 18.2]
Analysis 18.2. Comparison 18 Adverse events: delayed versus no antibiotics, Outcome 2 Diarrhoea.
[Analysis 18.3]
Analysis 18.3. Comparison 18 Adverse events: delayed versus no antibiotics, Outcome 3 Rash.
[Analysis 18.4]
Analysis 18.4. Comparison 18 Adverse events: delayed versus no antibiotics, Outcome 4 Stomach ache.
[Analysis 19.1]
Analysis 19.1. Comparison 19 Re-consultation rate; delayed versus immediate antibiotics, Outcome 1 Re-consultation rate.
[Analysis 20.1]
Analysis 20.1. Comparison 20 Subsequent consultation rates in the 12 months following the index consultation (excluding first month following consultation); delayed versus immediate antibiotics, Outcome 1 Re-consultation in the 12 months following the index consultation (excluding the first month following the index consultation).