Chemotherapy, surgery and radiotherapy for locally advanced breast cancer

  • Protocol
  • Intervention



This is the protocol for a review and there is no abstract. The objectives are as follows:

1. To assess the impact of different combinations of local therapies and systemic therapies on survival and locoregional disease control in locally advanced breast cancer.

Specifically, for local therapies,
the effect of differing amounts and type of local therapy (surgery and radiotherapy, either alone or in combination)
the effect of different sequences of local therapy (surgery then radiotherapy or vice versa)

and for systemic therapies
the effect of differing amounts and duration of treatment (for example, more chemotherapy versus less or chemotherapy with or without endocrine therapy)
the effect of sequence in relation to local therapy (chemotherapy before or after local therapy)

2. To determine if overall duration or amount of therapy influences treatment outcome