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Antibiotics for treating chronic osteomyelitis in adults

  1. Lucieni O Conterno1,*,
  2. Marilia D Turchi2

Editorial Group: Cochrane Bone, Joint and Muscle Trauma Group

Published Online: 6 SEP 2013

Assessed as up-to-date: 9 APR 2013

DOI: 10.1002/14651858.CD004439.pub3


How to Cite

Conterno LO, Turchi MD. Antibiotics for treating chronic osteomyelitis in adults. Cochrane Database of Systematic Reviews 2013, Issue 9. Art. No.: CD004439. DOI: 10.1002/14651858.CD004439.pub3.

Author Information

  1. 1

    Marilia Medical School, Department of General Internal Medicine and Clinical Epidemiology Unit, Marilia, São Paulo, Brazil

  2. 2

    Federal University of Goias, Department of Public Health, Institute of Tropical Pathology and Public Health, Goiania, Goias, Brazil

*Lucieni O Conterno, Department of General Internal Medicine and Clinical Epidemiology Unit, Marilia Medical School, Avenida Monte Carmelo 800, Fragata, Marilia, São Paulo, 17519-030, Brazil. lucieni@famema.br.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 6 SEP 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Euba 2009 {published data only}
  • Cardenal JA. Oral rifampin-cotrimoxazole combination versus intravenous cloxacillin in chronic staphylococcal osteomyelitis: a long-term follow-up trial. http://isrctn.org/ISRCTN27058472 (accessed 20 April 2013) 2008.
  • Euba G, Murillo O, Fernandez-Sabé N, Mascaró J, Cabo J, Perez A, et al. Long-term follow-up trial of oral rifampin-cotrimoxazole combination versus intravenous cloxacillin in treatment of chronic staphylococcal osteomyelitis. Antimicrobial Agents and Chemotherapy 2009;53(6):2672-6.
Gentry 1990 {published data only}
Gentry 1991 {published data only}
Gomis 1999 {published data only}
  • Gomis M, Barberan J, Sanchez B, Khorrami S, Borja J, Garcia BJ. Oral ofloxacin versus parenteral imipenem-cilastatin in the treatment of osteomyelitis [Ofloxacino oral versus imipenem-cilastatina intravenoso en el tratamiento de la osteomielitis]. Revista Espanola de Quimioterapia 1999;12(3):244-9.
Greenberg 2000 {published data only}
Mader 1990 {published data only}
  • Mader JT, Cantrell JS, Calhoun J. Oral ciprofloxacin compared with standard parenteral antibiotic therapy for chronic osteomyelitis in adults. Journal of Bone Joint Surgery - American Volume 1990;72(1):104-10.
Norden 1986 {published data only}
  • Norden CW, Bryant R, Palmer D, Montgomerie JZ, Wheat J. Chronic osteomyelitis caused by Staphylococcus aureus: controlled clinical trial of nafcillin therapy and nafcillin-rifampin therapy. Southern Medical Journal 1986;79(8):947-51.
  • Norden CW, Fierer J, Bryant RE. Chronic Staphylococcus osteomyelitis: treatment with regimens containing rifampin. Reviews of Infectious Diseases 1983;5(Suppl 3):S495-501.
Sheftel 1986 {published data only}
  • Sheftel TG, Mader JT. Randomized evaluation of ceftazidime or ticarcillin and tobramycin for the treatment of osteomyelitis caused by gram-negative bacilli. Antimicrobial Agents and Chemotherapy 1986;29(1):112-5.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Baumgartner 1983 {published data only}
  • Baumgartner JD, Glauser MP. Comparative study of imipenem in severe infections. Journal of Antimicrobial Chemotherapy 1983;12(Suppl D):141-8.
Giamarellou 1989 {published data only}
  • Giamarellou H, Perdikaris G, Galanakis N, Davoulos G, Mandragos K, Sfikakis P. Pefloxacin versus ceftazidime in the treatment of a variety of gram-negative-bacterial infections. Antimicrobial Agents and Chemotherapy 1989;33(8):1362-7.
Greenberg 1987 {published data only}
  • Greenberg RN, Tice AD, Marsh PK, Craven PC, Reilly PM, Bollinger M, et al. Randomized trial of ciprofloxacin compared with other antimicrobial therapy in the treatment of osteomyelitis. American Journal of Medicine 1987;82(4A):266-9.
Hedstrom 1975 {published data only}
  • Hedstrom SA. Treatment of chronic staphylococcal osteomyelitis with cloxacillin and dicloxacillin - a comparative study in 12 patients. Scandinavian Journal of Infectious Diseases 1975;7(1):55-7.
Ingianni 2007 {published data only}
  • Ingianni A, Lampis G, Laconi S, Cariello D, Pompei R. Standard versus specific therapy for chronic osteomyelitis treatment. American Journal of Infectious Diseases 2007;3(3):128-33.
Loffler 1986 {published data only}
  • Loffler L, Bauernfeind A, Keyl W. Sulbactam/ampicillin versus cefotaxime as initial therapy in serious soft tissue, joint and bone infections. Drugs 1988;35(Suppl 7):46-52.
  • Loffler L, Bauernfeind A, Keyl W, Hoffstedt B, Piergies A, Lenz W. An open, comparative study of sulbactam plus ampicillin vs. cefotaxime as initial therapy for serious soft tissue and bone and joint infections. Reviews of Infectious Diseases 1986;8(Suppl 5):S593-8.
Mandell 1989 {published data only}
  • Mandell LA, Bergeron MG, Ronald AR, Vega C, Harding G, Saginur R, et al. Once-day therapy with ceftriaxone compared with daily multiple-dose therapy with cefotaxime for serious bacterial infections: a randomised, double-blind study. Journal of Infectious Diseases 1989;160(3):433-41.
Marier 1983 {published data only}
  • Marier RL, McCloskey RV, Dickenson G, Sanders CV, Aldridge KE, Hoffman T, et al. Comparative clinical trial of imipenem-cilastatin (N-formimidoyl-thienamycin-dehydropeptidase inhibitor) and cefazolin. Journal of Antimicrobial Chemotherapy 1983;12(Suppl D):133-9.
Marriott 2008 {published data only}
  • Marriott R, Rubayi S. Successful truncated osteomyelitis treatment for chronic osteomyelitis secondary to pressure ulcers in spinal cord injury patients. Annals of Plastic Surgery 2008;61(4):425-9.
Nguyen 2009 {published data only}
  • Nguyen S, Pasquet A, Legout L, Beltrand E, Dubreuil L, Migaud H, et al. Efficacy and tolerance of rifampicin–linezolid compared with rifampicin–cotrimoxazole combinations in prolonged oral therapy for bone and joint infections. Clinical Microbiology and Infection 2009;15(12):1163-9.
Paladino 1991 {published data only}
  • Paladino JA, Sperry HE, Backes JM, Gelber JA, Serrianne, DJ, Cumbo TJ, et al. Clinical and economic evaluation of oral ciprofloxacin after an abbreviated course of intravenous antibiotics. American Journal of Medicine 1991;91(5):462-70.
Peacock 1989 {published data only}
  • Peacock JE Jr, Pegram PS, Weber SF, Leone PA. Prospective, randomised comparison of sequential intravenous followed by oral ciprofloxacin with intravenous ceftazidime in the treatment of serious infections. American Journal of Medicine 1989;87(5A):185S-90S.
Reinhardt 1986 {published data only}
  • Reinhardt JF, Jonnston L, Ruane P, Johnson CC, Ingram-drake L, MacDonald K, et al. A randomised, double-blind comparison of sulbactam/ampicillin and clindamycin for the treatment of aerobic and aerobic-anaerobic infections. Reviews of Infectious Diseases 1986;8(Suppl 5):S569-75.
Siebert 1985 {published data only}
  • Siebert WT, Kopp PE. Ticarcillin plus clavulanic acid versus moxalactam therapy of osteomyelitis, septic arthritis, and skin and soft tissue infections. American Journal of Medicine 1985;79(5B):141-5.
Tascini 2009 {published data only}
  • Tascini C, Tagliaferri E, Di Paolo A, Del Tacca M, Lambelet P, Menichetti F. Three-times weekly teicoplanin as outpatient treatment of chronic osteoarticular infections. Journal of Chemotherapy 2009;21(4):421-5.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Barberán 2000 {published data only}
  • Barberán J, Gomis M, Sánchez B, Hernández-Salván J, García Del Salto L, Carroquino G, et al. Cefepime in the treatment of osteomyelitis caused by Gram negative bacilli [Cefepima en el tratamiento de la osteomielitis por bacilos gramnegativos]. Revista Espanola de Quimioterapia 2000;13(4):366-73.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
CTRI/2008/091/000060 {published data only}
  • Saraf N, Mudgai M. A clinical trial to study the safety and efficacy of combination drugs, vancomycin and ceftriaxone compared to vancomycin in mild to severe bacterial infections. http://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=100&EncHid=&userName=ceftriaxone (accessed 12 August 2013) 2008.
EUCTR2009-015744-42-GB {published data only}
  • Oxford Radcliffe Hospital Trust (sponsor). Randomised open label study of oral versus intravenous antibiotic treatment for bone and joint infections requiring prolonged antibiotic treatment. http://apps.who.int/trialsearch/Trial.aspx?TrialID=EUCTR2009-015744-42-GB (accessed 20 April 2013) 2009. [EUCTR2009-015744-42-GB]
NCT00324922 {published data only}
  • Ramers C, Taistman L, Harrington R, Chan J, Henley BM, Hawn TR, et al. A prospective randomised trial comparing vancomycin with trimethoprim/sulphamethoxazole for the treatment of MRSA osteomyelitis. http://clinicaltrials.gov/show/NCT00324922 (accessed 20 April 2013) 2006.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Bourguignat 1996
Carek 2001
Ciampolini 2000
Cierny 1985
  • Cierny G 3rd, Mader JT, Penninck JJ. A clinical staging system for adult osteomyelitis. Contemporary Orthopaedics 1985;10:17-37.
Cierny 2003
Cunha 2002
Darouiche 2004
Eckardt 1994
  • Eckardt JJ, Wirganowicz PZ, Mar T. An aggressive surgical approach to the management of chronic osteomyelitis. Clinical Orthopaedics and Related Research 1994;(298):229-39.
Ferard 2002
  • Ferard G, Gaudias J, Bourguignat A, Ingenbleek Y. C-reactive protein to transthyretin ratio for the early diagnosis and follow-up of postoperative infection. Clinical Chemistry and Laboratory Medicine 2002;40(12):1334-8.
Gristina 1990
  • Gristina AG, Naylor PT, Myrvik QN. Musculoskeletal infection, microbial adhesion, and antibiotic resistance. Infectious Disease Clinics of North America 1990;4(3):391-408.
Haas 1996
Haidar 2010
  • Haidar R, Der Boghossian A, Atiyeh B. Duration of post-surgical antibiotics in chronic osteomyelitis: empiric or evidence-based?. International Journal of Infectious Diseases 2010;14(9):e752-8.
Higgins 2003
Higgins 2006
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Holtom 1999
  • Holtom PD, Smith AM. Introduction to adult posttraumatic osteomyelitis of the tibia. Clinical Orthopaedics and Related Research 1999;(360):6-13.
Huber 2002
  • Huber AM, Lam PY, Duffy CM, Yeung RS, Ditchfield M, Laxer D, et al. Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. Journal of Pediatrics 2002;141(2):198-203.
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Karamanis 2008
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Mader 1999a
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Conterno 2009