Intervention Review

Recombinant Factor VIIa concentrate versus plasma derived concentrates for the treatment of acute bleeding episodes in people with haemophilia and inhibitors

  1. Alfonso Iorio1,*,
  2. Davide Matino2,
  3. Roberto D'Amico3,
  4. Michael Makris4

Editorial Group: Cochrane Cystic Fibrosis and Genetic Disorders Group

Published Online: 4 AUG 2010

Assessed as up-to-date: 6 JUL 2010

DOI: 10.1002/14651858.CD004449.pub3


How to Cite

Iorio A, Matino D, D'Amico R, Makris M. Recombinant Factor VIIa concentrate versus plasma derived concentrates for the treatment of acute bleeding episodes in people with haemophilia and inhibitors. Cochrane Database of Systematic Reviews 2010, Issue 8. Art. No.: CD004449. DOI: 10.1002/14651858.CD004449.pub3.

Author Information

  1. 1

    McMaster University, Clinical Epidemiology and Biostatistic Department, Hamilton, ON, Canada

  2. 2

    University of Perugia, Department of Internal Medicine, Perugia, Italy

  3. 3

    University of Modena and Reggio Emilia, Statistics Unit, Department of Oncology, Hematology and Respiratory Disease, Modena, Italy

  4. 4

    University of Sheffield, Academic Unit of Haematology, Sheffield, UK

*Alfonso Iorio, Clinical Epidemiology and Biostatistic Department, McMaster University, 1280 Main Street West, CRL - 140, Hamilton, ON, L8S 4K1, Canada. iorioa@mcmaster.ca.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 4 AUG 2010

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This article has been cited by:

  1. 1
    J. J. Veen, R. M. Maclean, K. K. Hampton, A. Hamer, M. Makris, Major surgery in severe haemophilia A with inhibitors using a recombinant factor VIIa and activated prothrombin complex concentrate hybrid regimen, Haemophilia, 2014, 20, 4
  2. You have free access to this content2
    Peter W. Collins, Elizabeth Chalmers, Daniel P. Hart, Ri Liesner, Savita Rangarajan, Kate Talks, Mike Williams, Charles R. Hay, Diagnosis and treatment of factor VIII and IX inhibitors in congenital haemophilia: (4th edition), British Journal of Haematology, 2013, 160, 2
  3. 3
    Zheng-Yi Zhou, Joel W. Hay, Efficacy of Bypassing Agents in Patients With Hemophilia and Inhibitors: A Systematic Review and Meta-Analysis, Clinical Therapeutics, 2012, 34, 2, 434

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  4. 4
    Mindy L Simpson, Barbara A Konkle, Sarah J Nolan, Shweta Jain, Maissaa Janbain, Amina Rafique, Bypassing agent prophylaxis in people with hemophilia A or B with inhibitors, The Cochrane Library,
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    Yi Liu, Lingli Zhang, Cristina Santoro, Jie Song, Armando Rodriguez, Li Wang, Rituximab for treating inhibitors in children with hemophilia, The Cochrane Library,