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Intervention Protocol

Perioperative beta-blockers for preventing surgery related mortality and morbidity

  1. Franz Wiesbauer2,
  2. Hans Domanovits3,
  3. Oliver Schlager4,
  4. Brigitte Wildner5,
  5. Martin Schillinger4,
  6. Hermann Blessberger1,*

Editorial Group: Cochrane Anaesthesia Group

Published Online: 22 APR 2003

DOI: 10.1002/14651858.CD004476


How to Cite

Wiesbauer F, Domanovits H, Schlager O, Wildner B, Schillinger M, Blessberger H. Perioperative beta-blockers for preventing surgery related mortality and morbidity (Protocol). Cochrane Database of Systematic Reviews 2003, Issue 2. Art. No.: CD004476. DOI: 10.1002/14651858.CD004476.

Author Information

  1. 1

    General Hospital Linz (AKH Linz), Rotation, Linz, Linz, Austria

  2. 2

    General Hospital Vienna, Department of Cardiology, Vienna, Austria

  3. 3

    Vienna University Hospital, Department of Emergency Medicine, Vienna, Austria

  4. 4

    Vienna University Hospital, Department of Internal Medicine II, Vienna, Austria

  5. 5

    Austrian Central Library of Medicine, Information Retrieval Office, Vienna, Austria

*Hermann Blessberger, Rotation, General Hospital Linz (AKH Linz), Krankenhausstraße 9, Linz, Linz, 4021, Austria. hermann.blessberger@meduniwien.ac.at. hermann.blessberger@akh.linz.at.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 22 APR 2003

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The objective of this review will be to systematically analyse the evidence of the effect of perioperatively administered beta-adrenoceptor blocking agents for the prevention of surgery related mortality and morbidity. Study participants should be individuals 18 years or older undergoing any type of surgery. We will be looking at some of the most debilitating surgery related complications. The primary outcome of our study will be all cause mortality (up to 30 days postoperatively).

Secondary outcomes will be:

  • Long term all cause mortality.
  • Incidence of acute myocardial infarction (AMI).
  • Myocardial ischaemia.
  • Dysrhythmias.
  • Cerebrovascular complications.

  • Congestive heart failure.
  • Length of stay.
  • Quality of life.

Administration of the drug should have been started preoperatively or at least one day postoperatively. There will be no limit on the maximum duration of beta-blocker administration. For a detailed list of outcomes please refer to the section "Types of outcome measures", below.