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Perioperative beta-blockers for preventing surgery related mortality and morbidity

  • Protocol
  • Intervention



This is the protocol for a review and there is no abstract. The objectives are as follows:

The objective of this review will be to systematically analyse the evidence of the effect of perioperatively administered beta-adrenoceptor blocking agents for the prevention of surgery related mortality and morbidity. Study participants should be individuals 18 years or older undergoing any type of surgery. We will be looking at some of the most debilitating surgery related complications. The primary outcome of our study will be all cause mortality (up to 30 days postoperatively).

Secondary outcomes will be:

  • Long term all cause mortality.

  • Incidence of acute myocardial infarction (AMI).

  • Myocardial ischaemia.

  • Dysrhythmias.

  • Cerebrovascular complications.

  • Congestive heart failure.

  • Length of stay.

  • Quality of life.

Administration of the drug should have been started preoperatively or at least one day postoperatively. There will be no limit on the maximum duration of beta-blocker administration. For a detailed list of outcomes please refer to the section "Types of outcome measures", below.