Premedication for endotracheal intubation in neonates

  • Protocol
  • Intervention



This is the protocol for a review and there is no abstract. The objectives are as follows:

The overall objective is to assess the effectiveness and safety of premedications in reducing stress/pain in neonates undergoing endotracheal intubation.

In separate comparisons we will assess the effectiveness and potential harmful effects of premedications in reducing stress/pain when used in isolation or in combination, as compared to placebo or nothing, or other premedication. The following comparisons are planned:

  • Anticholinergics vs Placebo/or nothing

  • Analgesics vs Placebo/or nothing

  • Anxiolytics vs Placebo/or nothing

  • Neuromuscular blocking agents vs Placebo/or nothing

  • Anxiolytics vs Analgesics

  • Neuromuscular blocking agents vs Anxiolytics

  • Anticholinergics vs Anticholinergics and Neuromuscular blocking agents

  • A combination of drugs vs placebo/or nothing

  • One combination of drugs vs another combination of drugs

We plan sub-group analyses in the following sub-groups of neonates

  • Preterm (<37 weeks) vs Term (>37 weeks)

  • Birth weight <2500 grams vs >2500 grams