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Intervention Protocol

Premedication for endotracheal intubation in neonates

  1. Abhay Lodha1,*,
  2. Arne Ohlsson2,
  3. Vibhuti S Shah1

Editorial Group: Cochrane Neonatal Group

Published Online: 20 OCT 2003

Assessed as up-to-date: 17 JUL 2003

DOI: 10.1002/14651858.CD004499


How to Cite

Lodha A, Ohlsson A, Shah VS. Premedication for endotracheal intubation in neonates (Protocol). Cochrane Database of Systematic Reviews 2003, Issue 4. Art. No.: CD004499. DOI: 10.1002/14651858.CD004499.

Author Information

  1. 1

    Mount Sinai Hospital, Department of Paediatrics, Toronto, Ontario,, Canada

  2. 2

    University of Toronto, Departments of Paediatrics, Obstetrics and Gynaecology and Health Policy, Management and Evaluation, Warkworh, Ontario, Canada

*Abhay Lodha, Department of Paediatrics, Mount Sinai Hospital, Rm 775A-600 University Avenue, Toronto, Ontario,, M5G 1X5, Canada. drabhaylodha@hotmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 20 OCT 2003

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The overall objective is to assess the effectiveness and safety of premedications in reducing stress/pain in neonates undergoing endotracheal intubation.

In separate comparisons we will assess the effectiveness and potential harmful effects of premedications in reducing stress/pain when used in isolation or in combination, as compared to placebo or nothing, or other premedication. The following comparisons are planned:

  • Anticholinergics vs Placebo/or nothing
  • Analgesics vs Placebo/or nothing
  • Anxiolytics vs Placebo/or nothing
  • Neuromuscular blocking agents vs Placebo/or nothing
  • Anxiolytics vs Analgesics
  • Neuromuscular blocking agents vs Anxiolytics
  • Anticholinergics vs Anticholinergics and Neuromuscular blocking agents
  • A combination of drugs vs placebo/or nothing
  • One combination of drugs vs another combination of drugs

We plan sub-group analyses in the following sub-groups of neonates

  • Preterm (<37 weeks) vs Term (>37 weeks)
  • Birth weight <2500 grams vs >2500 grams