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Methotrexate for ankylosing spondylitis

  1. Junmin Chen1,*,
  2. Mirella MS Veras2,
  3. Chao Liu3,
  4. Junfang Lin1

Editorial Group: Cochrane Musculoskeletal Group

Published Online: 28 FEB 2013

Assessed as up-to-date: 20 NOV 2012

DOI: 10.1002/14651858.CD004524.pub4


How to Cite

Chen J, Veras MMS, Liu C, Lin J. Methotrexate for ankylosing spondylitis. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD004524. DOI: 10.1002/14651858.CD004524.pub4.

Author Information

  1. 1

    The First Affiliated Hospital of Fujian Medical University, Department of Hematology and Rheumatology, Fuzhou, Fujian Province, China

  2. 2

    University of Ottawa, Centre for Global Health, Institute of Population Health, Ottawa, Ontario, Canada

  3. 3

    The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China

*Junmin Chen, Department of Hematology and Rheumatology, The First Affiliated Hospital of Fujian Medical University, #20 Chazhong Road, Fuzhou, Fujian Province, 350005, China. drjunminchen@hotmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 FEB 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Altan 2001 {published data only}
  • Altan L, Bingol U, Karakoc Y, Aydiner S, Yurtkuran M, Yurtkuran M. Clinical investigation of methotrexate in the treatment of ankylosing spondylitis. Scandinavian Journal of Rheumatology 2001;30(5):255-9.
Gonzalez-Lopez 2004 {published data only}
  • Gonzalez-Lopez L, Garcia-Gonzalez A, Vazquez-Del-Mercado M, Munoz-Valle JF, Gamez-Nava JI. Efficacy of methotrexate in ankylosing spondylitis: a randomized, double blind, placebo controlled trial. The Journal of Rheumatology 2004;31(8):1568-74.
Roychowdhury 2002 {published data only}
  • Roychowdhury B, Bintley-Bagot S, Bulgen DY, Thompson RN, Tunn EJ, Moots RJ. Is methotrexate effective in ankylosing spondylitis?. Rheumatology (Oxford) 2002;41( 11 ):1330-2.
  • Roychowdhury B, Bintley-Bagot S, Hunt J, Tunn EJ. Methotrexate in severe ankylosing spondylitis: a randomised placebo controlled, double-blind observer study. Rheumatology 2001;40(Suppl 1):43.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Breban 2008 {published data only}
  • Breban M, Ravaud P, Claudepierre P, Baron G, Henry YD, Hudry C, et al. Maintenance of infliximab treatment in ankylosing spondylitis: results of a one-year randomized controlled trial comparing systematic versus on-demand treatment. Arthritis and Rheumatism 2008;58(1):88-97.
  • Breban M, Ravaud P, Claudepierre P, Baron G, Hudry C, Euller-Ziegler L, et al. No superiority of infliximab (INF) + methotrexate (MTX) over INF alone in the treatment of ankylosing spondylitits (AS): results of a one-year randomized prospective study. Arthritis and Rheumatism 2005;52(Suppl 9):S214.
Kabasakal 2009 {published data only}
  • Kabasakal Y, Kitapcioglu G, Yargucu F, Taylan A, Argin M, Gumusdis G. Efficacy of SLZ and MTX (alone or combinaiton) on the treatment of sacroiliitis in early AS. Rheumatology International 2009;29(12):1523-7.
Li 2008 {published data only}
  • Li EK, Griffith JF, Lee VW, Wang YX, Li TK, Lee KK, et al. Short-term efficacy of combination methotrexate and infliximab in patients with ankylosing spondylitis: a clinical and magnetic resonance imaging correlation. Rheumatology (Oxford) 2008;47(9):1358-63.
  • Li EK, Griffith JF, Lee VW, Wang YX, Li TK, Lee KK, et al. Short-term efficacy of combination methotrexate and infliximab in patients with ankylosing spondylitis: a clinical and magnetic resonance imaging correlation. Erratum. Rheumatology (Oxford) 2010;49(7):1423.
Mulleman 2011 {published data only}
  • Mulleman D, Lauferon F, Wendling D, Ternant D, Ducourau E, Paintaud G, et al. Infliximab in ankylosing spondylitis: alone or in combination with methotrexate? A pharmacokinetic comparative study. Arthritis Research and Therapy 2011;13(3):R82.
Pérez-Guijo 2007 {published data only}
  • Pérez-Guijo VC, Cravo AR, Castro MdelC, Font P, Muñoz-Gomariz E, Collantes-Estevez E. Increased efficacy of infliximab associated with methotrexate in ankylosing spondylitis. Joint Bone Spine 2007;74(3):254-8.
Xie 2003 {published data only}
  • Xie RL, Li XH, Kang XT. Methotrexate in conjunction with meloxicam for treating ankylosing spondylitis: a clinical observation of the efficacy and safety. Di Yi Jun Yi Da Xue Xue Bao (Academic journal of the First Medical College of PLA) 2003;23(5):460-2.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Haque 1999 {published data only}
  • Haque MA, Bari MA, Saha GK, Ali MA, Hoque SA, Abdullah ABM. Prospective, nonblind trial of methotrexate on seronegative spondyloarthropathy. Journal of Institute of Postgraduate Medicine and Research 1999;14(2):56-63.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
ACR 2002
Akkoc 2005
Annelies 2006
  • Boonen A, van der Linden SM. The burden of ankylosing spondylitis. The Journal of Rheumatology. Supplement 2006;78:4-11.
Biasi 2000
  • Biasi D, Carletto A, Caramaschi P, Pacor ML, Maleknia T, Bambara LM. Efficacy of methotrexate in the treatment of ankylosing spondylitis: a three-year open study. Clinical Rheumatology 2000;19(2):114-7.
Chen 2005
Clavaguera 1998
  • Clavaguera MT, Juanola X, Narvaez FJ. Methotrexate in the treatment of ankylosing spondylitis. British Journal of Rheumatology 1998;37(Suppl 1):45.
Creemers 1995
  • Creemers MC, Franssen MJ, van de Putte LB, Gribnau FW, van Riel PL. Methotrexate in severe ankylosing spondylitis: an open study. Journal of Rheumatology 1995;22(6):1104-7.
Haibel 2007
  • Haibel H, Brandt HC, Song IH, Brandt A, Listing J, Rudwaleit M, et al. No efficacy of subcutaneous methotrexate in active ankylosing spondylitis: a 16-week open-label trial. Annals of the Rheumatic Diseases 2007;66(3):419-21.
Handler 1989
Higgins 2011
  • Higgins J, Altman DG. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.0.2 (updated September 2009. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Katchamart 2010
  • Katchamart W, Trudeau J, Phumethum V, Bombardier C. Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis. Cochrane Database of Systematic Reviews 2010, Issue 4. [DOI: 10.1002/14651858.CD008495]
Kirnap 2000
  • Kirnap M, Demir H, Sigan YT, Koc H, Ozsoy O. Efficacy and side effects of low dose methotrexate treatment in the patients with ankylosing spondylitis. Journal of Rheumatology 2000;27(Suppl 59):57.
Maini 1998
  • Maini RN, Breedveld FC, Kalden JR, Smolen JS, Davis D, MacFarlane JD, et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis and Rheumatism 1998;41(9):1552-63.
McLeod 2007
  • McLeod C, Bagust A, Boland A, Dagenais P, Dickson R, Dundar Y, et al. Adalimumab, etanercept and infliximab for the treatment of ankylosing spondylitis: a systematic review and economic evaluation. Health Technology Assessment 2007;11(28):1-158.
Olivieri 2002
Ostendorf 1998
  • Ostendorf B, Specker C, Schneider M. Methotrexate lacks efficacy in the treatment of severe ankylosing spondylitis compared with rheumatoid and psoriatic arthritis. Journal of Clinical Rheumatology 1998;4(3):129-36.
Perez-Guijo 2007
  • Perez-Guijo VC, Cravo AR, Castro Mdel C, Font P, Munoz-Gomariz E, Collantes-Estevez E. Increased efficacy of infliximab associated with methotrexate in ankylosing spondylitis.. Joint Bone Spine 2007;74(3):254-8.
Review Manager (RevMan)
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Sampaio-Barros 2000
Sieper 2009
  • Sieper J, Rudwaleit M, Baraliakos X, Brandt J, Braun J, Burgos-Vargas R, et al. The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis. Annal of the Rheumatic Diseases 2009;68(Suppl 2):ii1-44.
Smolen 2010
  • Smolen JS, Landewé R, Breedveld FC, Dougados M, Emery P, Gaujoux-Viala C, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Annals of the Rheumatic Diseases 2010;69(6):964-75.
Suarez-Almazor 2003
van der Heijde 1999
  • van der Heijde D, van der Linden S, Bellamy N, Calin A, Dougados M, Khan MA. Which domains should be included in a core set for endpoints in ankylosing spondylitis? Introduction to the ankylosing spondylitis module of OMERACT IV. The Journal of Rheumatology 1999;26(4):945-7.
van der Heijde 2002
  • van der Heijde D, Braun J, McGonagle D, Siegel J. Treatment trials in ankylosing spondylitis: current and future considerations. Annals of the Rheumatic Diseases 2002;61(Suppl 3):iii24-32.
van der Heijde 2005
Zochling 2005
  • Zochling J, Maxwell L, Beardmore J, Boonen A. TNF-alpha inhibitors for ankylosing spondylitis. Cochrane Database of Systematic Reviews 2005, Issue 3. [DOI: 10.1002/14651858.CD005468]

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Chen 2004
  • Chen J, Liu C. Methotrexate for ankylosing spondylitis. Cochrane Database of Systematic Reviews 2003, Issue 3. [DOI: 10.1002/14651858.CD004524.pub2]
Chen 2006