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Atovaquone-proguanil for treating uncomplicated malaria

  1. Alex Osei-Akoto1,*,
  2. Lois C Orton2,
  3. Shirley Owusu-Ofori3

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 21 JAN 2009

Assessed as up-to-date: 26 JUN 2005

DOI: 10.1002/14651858.CD004529.pub2

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Additional Information

How to Cite

Osei-Akoto A, Orton LC, Owusu-Ofori S. Atovaquone-proguanil for treating uncomplicated malaria. Cochrane Database of Systematic Reviews 2005, Issue 4. Art. No.: CD004529. DOI: 10.1002/14651858.CD004529.pub2.

Author Information

  1. 1

    Komfo Anokye Teaching Hospital, Department of Child Health, Kumasi, Ghana

  2. 2

    University of Manchester, School of Nursing, Midwifery and Social Work, Manchester, UK

  3. 3

    Komfo Anokye Teaching Hospital, Department of Medicine, Kumasi, Ghana

*Alex Osei-Akoto, Department of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana. oseiyakoto@hotmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 JAN 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Anabwani 1999 {published data only}
  • Anabwani G, Canfield CJ, Hutchinson DB. Combination atovquone and proguanil hydrochloride vs. halofantrine for treatment of acute Plasmodium falciparum malaria in children. Pediatric Infectious Disease Journal 1999;18(5):456-61.
Borrmann 2003 {published data only}
  • Borrmann S, Faucher J-F, Bagaphou T, Missinou MA, Binder RK, Pabisch S, et al. Atovaquone and proguanil versus amodiaquine for the treatment of Plasmodium falciparum malaria in African infants and young children. Clinical Infectious Diseases 2003;37(11):1441-7.
Bouchaud 2000 {published data only}
  • Bouchaud O, Monlun E, Muanza K, Fontanet A, Scott T, Goetschel A, et al. Atovaquone plus proguanil versus halofantrine for the treatment of imported acute uncomplicated Plasmodium falciparum malaria in non-immune adults: a randomized comparative trial. American Journal of Tropical Medicine and Hygiene 2000;63(5-6):274-9.
De Alencar 1997 {published data only}
  • de Alencar FE, Cerutti C Jr, Durlacher RR, Boulos M, Alves FP, Milhous W, et al. Atovaquone and proguanil for the treatment of malaria in Brazil. Journal of Infectious Diseases 1997;175(6):1544-7.
Giao 2004 {published data only}
  • Giao PT, de Vries PJ, Hung le Q, Binh TQ, Nam NV, Kager PA. CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam. Tropical Medicine and International Health 2004;9(2):209-16.
    Direct Link:
Llanos-Cuentas 2001 {published data only}
  • Llanos-Cuentas A, Campos P, Clendenes M, Canfield CJ, Hutchinson DB. Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru. Brazilian Journal of Infectious Diseases 2001;5(2):67-72.
Looareesuwan 1999a {published data only}
  • Looareesuwan S, Wilairatana P, Chalermarut K, Rattanapong Y, Canfield CJ, Hutchinson DB. Efficacy and safety of atovaquone/proguanil compared with mefloquine for treatment of acute Plasmodium falciparum malaria in Thailand. American Journal of Tropical Medicine and Hygiene 1999;60(4):526-32.
Mulenga 1999 {published data only}
  • Mulenga M, Sukwa TY, Canfield CJ, Hutchinson DB. Atovaquone and proguanil versus pyrimethamine/sulfadoxine for the treatment of acute falciparum malaria in Zambia. Clinical Therapeutics 1999;21(5):841-52.
Radloff 1996 {published data only}
Van Vugt 2002 {published data only}
  • van Vugt M, Leonardi E, Phaipun L, Slight T, Thway KL, McGready R, et al. Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil. Clinical Infectious Diseases 2002;35(12):1498-504.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bustos 1999 {published data only}
  • Bustos DG, Canfield CJ, Canete-Miguel E, Hutchinson DB. Atovaquone-proguanil compared with chloroquine-sulfadoxine-pyrimethamine for treatment of acute Plasmodium falciparum malaria in the Philippines. The Journal of Infectious Diseases 1999;179(6):1587-90.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Beerahee 1999
  • Beerahee M. Clinical pharmacology of atovaquone and proguanil hydrochloride (http://www.malarone.com/hcp/clinical.html). Journal of Travel Medicine 1999; Vol. 6 Suppl 1.
Blanchard 1994
  • Blanchard TJ, Mabey DC, Hunt-Cooke A, Edwards G, Hutchinson DB, Benjamin S, et al. Multiresistant falciparum malaria cured using atovaquone and proguanil. Transactions of the Royal Society of Tropical Medicine and Hygiene 1994;88(6):693.
Bloland 1997
Brockman 1999
  • Brockman A, Paul RE, Anderson TJ, Hackford I, Phaiphun L, Looareesuwan S, et al. Application of genetic markers to the identification of recrudescent Plasmodium falciparum infections on the northwestern border of Thailand. American Journal of Tropical Medicine and Hygiene 1999;60(1):14-21.
Canfield 1995
Dollery 1991
  • Dollery C, editor. Poguanil hydrochloride. Therapeutic Drugs. 2nd Edition. Vol. 2, New York: Churchill Livingstone, 1991:247-51.
Foege 1997
Fry 1992
  • Fry M, Pudney M. Site of action of the antimalarial hydroxynaphttoquinone, 2-[trans-4-(4'-chlophenyl) cyclohexyl]-3-hydroxy-1, 4 naphthoquinone (566C80). Biochemical Pharmarmacology 1992;43(7):1545-53.
Higgins 2005
  • Higgins J, Green S, editors. Highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE. Cochrane Handbook for Systematic Reviews of Interventions 4.2.5 [updated May 2005]; Appendix 5b. http://www.cochrane.org/resources/handbook/index.htm (accessed 10 August 2005).
Hogh 2000
  • Hogh B, Clarke PD, Camus D, Nothdurft HD, Overbosch D, Gunther M, et al. Malarone International Study Team. Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in non-immune travellers: a randomised, double-blind study. Lancet 2000;356(9245):1888-94.
Jüni 2001
Kamya 2002
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Looareesuwan 1996
  • Looareesuwan S, Viravan C, Webster HK, Kyle DE, Hutchinson DB, Canfield CJ. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. American Journal of Tropical Medicine and Hygiene 1996;54(1):62-6.
Looareesuwan 1999b
  • Looareesuwan S, Chulay JD, Canfield CJ, Hutchinson DB. Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group. American Journal of Tropical Medicine and Hygiene 1999;60(4):533-41.
Ohrt 1997
  • Ohrt C, Mirabelli-Primdahl L, Karnasuta C, Chantakulkij S, Kain KC. Distinguishing Plasmodium falciparum treatment failures from reinfections by restriction fragment length polymorphism and polymerase chain reaction genotyping. American Journal of Tropical Medicine and Hygiene 1997;57(4):430-7.
Overbosch 2001
  • Overbosch D, Schilthuis H, Bienzle U, Behrens RH, Kain KC, Clarke PD, et al. Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: results from a randomized, double-blind study. Clinical Infectious Diseases 2001;33(7):1015-21.
Oyediran 2002
  • Oyediran AB, Ddumba EM, Ochola SA, Lucas AO, Koporc K, Dowdle WR. A public-private partnership for malaria control: lessons from the Malarone Donation Programme. Bulletin of the World Health Organization 2002;80(10):817-21.
Partnerships 2002
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RBM 2001a
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  • Global Partnership to Roll Back Malaria. The use of antimalarial drugs: report of an WHO informal consultation, 13-17 November 2000. Geneva: World Health Organization, 2001:32.
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  • Global Partnership to Roll Back Malaria. World malaria report: 2005. Geneva: World Health Organization, 2005.
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Ringwald 1998
Sabchareon 1998
  • Sabchareon A, Attanath P, Phanuaksook P, Chanthavanich P, Poonpanich Y, Mookmanee D, et al. Efficacy and pharmacokinetics of atovaquone and proguanil in children with multidrug-resistant Plasmodium falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 1998;92(2):201-6.
Shretta 2000
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Stepniewska 2004
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Sukwa 1999
  • Sukwa TY, Mulenga M, Chisdaka N, Roskell NS, Scott TR. A randomised, double-blind, placebo-controlled field trial to determine the efficacy and safety of Malarone (atovaquone/proguanil) for prophylaxis of malaria in Zambia. American Journal of Tropical Medicine and Hygiene 1999;60(4):521-5.
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