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Routine surgery in addition to chemotherapy for treating spinal tuberculosis

  1. Paul C Jutte1,*,
  2. Joke H van Loenhout-Rooyackers2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 17 MAR 2010

Assessed as up-to-date: 21 OCT 2007

DOI: 10.1002/14651858.CD004532.pub2

Database Title

Additional Information

How to Cite

Jutte PC, van Loenhout-Rooyackers JH. Routine surgery in addition to chemotherapy for treating spinal tuberculosis. Cochrane Database of Systematic Reviews 2006, Issue 1. Art. No.: CD004532. DOI: 10.1002/14651858.CD004532.pub2.

Author Information

  1. 1

    University Medical Center Groningen, Groningen, Netherlands

  2. 2

    GGD Regio Nijmegen (Public Health Office), Department of Tuberculosis, Nijmegen, Netherlands

*Paul C Jutte, University Medical Center Groningen, Hanzeplein 1, PO Box 30.001, Groningen, 9700 RB, Netherlands. p.c.jutte@orth.umcg.nl.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 17 MAR 2010

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[Figure 1]
Figure 1. Lateral radiograph of the spine shows a kyphosis angle because two vertebral bodies were destroyed by tuberculosis; the bodies have fused, and further deterioration of the angle is unlikely. The angle is measured by drawing lines parallel to the healthy vertebral bodies above and below the fused bodies
[Figure 2]
Figure 2. Lateral drawing of the spine illustrating the various levels
[Figure 3]
Figure 3. Participant flow in MRC 1974a
[Figure 4]
Figure 4. Participant flow in ICMR/MRC 1989
[Analysis 1.1]
Analysis 1.1. Comparison 1 Chemotherapy plus surgery versus chemotherapy alone, Outcome 1 Change of allocated treatment.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Chemotherapy plus surgery versus chemotherapy alone, Outcome 2 Clinically significant increase in kyphosis angle.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Chemotherapy plus surgery versus chemotherapy alone, Outcome 3 Improvement in neurological deficit.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Chemotherapy plus surgery versus chemotherapy alone, Outcome 4 Bony fusion.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Chemotherapy plus surgery versus chemotherapy alone, Outcome 5 Absence of spinal tuberculosis.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Chemotherapy plus surgery versus chemotherapy alone, Outcome 6 Deaths from any cause.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Chemotherapy plus surgery versus chemotherapy alone, Outcome 7 Regained activity level.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Chemotherapy plus surgery versus chemotherapy alone, Outcome 8 Deterioration of bone loss.
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