This is the protocol for a review and there is no abstract. The objectives are as follows:
1. The primary aim of this review will be to assess the adequacy of the antibiotic regimens in eradicating initial sepsis and the need for subsequent interventions to eradicate peritoneal sepsis. As part of the review, mortality associated with the initial pathology will be also be assessed and correlated to the efficacy of the different antibiotic regimens.
2. Patients with peritonitis frequently undergo surgery to treat the cause of infection, and a secondary objective is to identify whether certain systemic antibiotic regimens reduce post-operative infection rates and post-operative stay. Wound, urinary and chest infection rates will be specifically examined, together with an evaluation of the success of antibiotic regimens in adequate source control, most specifically the need for subsequent interventions to eradicate peritoneal sepsis.
3. Certain antibiotics, particularly the aminoglycosides, have higher toxicity compared to the others. We would aim to elucidate and compare the various adverse events relating to the regimens used.