Intervention Protocol

High versus low thresholds for repeat administration of surfactant in intubated preterm neonates

  1. David J. McCulley2,
  2. Gautham Suresh1,*,
  3. Roger Soll3

Editorial Group: Cochrane Neonatal Group

Published Online: 26 JAN 2004

Assessed as up-to-date: 24 SEP 2003

DOI: 10.1002/14651858.CD004594


How to Cite

McCulley DJ, Suresh G, Soll R. High versus low thresholds for repeat administration of surfactant in intubated preterm neonates (Protocol). Cochrane Database of Systematic Reviews 2004, Issue 1. Art. No.: CD004594. DOI: 10.1002/14651858.CD004594.

Author Information

  1. 1

    Dartmouth-Hitchcock Medical Center, Department of Pediatrics, Neonatal Division, Lebanon, NH, USA

  2. 2

    University of Vermont, Pediatric Residency Program, Burlington, Vermont, USA

  3. 3

    University of Vermont, Division of Neonatal-Perinatal Medicine, Burlington, Vermont, USA

*Gautham Suresh, Department of Pediatrics, Neonatal Division, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH, 03576-001, USA. gautham.suresh@hitchcock.org.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 26 JAN 2004

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

1. To determine, in preterm infants who have received an initial dose of surfactant either as prophylaxis or treatment of established respiratory distress syndrome, whether the use of a high threshold for administration of a second or subsequent dose of surfactant when compared to a low threshold leads to improved respiratory outcome, decreased morbidity associated with prematurity, decreased resource utilization and decreased mortality.

2. To compare the effects of high versus low thresholds in different subgroups formed on initial dosing strategy (prophylactic dosing versus rescue dosing), degree of prematurity, birth weight, type of ventilator (conventional versus HFOV), antenatal steroid use, and the type of surfactant (natural versus synthetic)