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Unit-dose packaged drugs for treating malaria

  1. Lois C Orton1,*,
  2. Guy Barnish2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 7 OCT 2009

Assessed as up-to-date: 24 MAR 2009

DOI: 10.1002/14651858.CD004614.pub2

Database Title

Additional Information

How to Cite

Orton LC, Barnish G. Unit-dose packaged drugs for treating malaria. Cochrane Database of Systematic Reviews 2005, Issue 2. Art. No.: CD004614. DOI: 10.1002/14651858.CD004614.pub2.

Author Information

  1. 1

    University of Manchester, School of Nursing, Midwifery and Social Work, Manchester, UK

  2. 2

    Liverpool School of Tropical Medicine, Disease Control Strategy Group, Liverpool, Merseyside, UK

*Lois C Orton, School of Nursing, Midwifery and Social Work, University of Manchester, University Place, Oxford Road, Manchester, M13 9PL, UK. Lois.Orton@manchester.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 7 OCT 2009

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Ansah 2003 {published data only}
  • Ansah EK, Gyapong JO, Agyepong IA, Evans DB. Improving adherence to malaria treatment for children: the use of pre-packed chloroquine tablets vs. chloroquine syrup. Tropical Medicine and International Health 2003;6(7):496-504.
    Direct Link:
Lauwo 2006 {published and unpublished data}
  • Lauwo JAK, Hombhanje FW, Tulo SP, Maibani G, Bjorge S. Impact of pre-packaging antimalarial drugs and counselling on compliance with malaria treatment at Port Moresby General Hospital Adult Outpatient Department. Papua New Guinea Medical Journal 2006;49:14-21.
Li 1998a {published and unpublished data}
  • Li Q, Duan J, Tang L, Zhang X, Liang J, Hay A, et al. The effect of drug packaging on patients' compliance with treatment for Plasmodium vivax malaria in China. Bulletin of the World Health Organization 1998;76 Suppl 1:21-7.
Li 1998b {published and unpublished data}
  • Li Q, Duan J, Tang L, Zhang X, Liang J, Hay A, et al. The effect of drug packaging on patients' compliance with treatment for Plasmodium vivax malaria in China. Bulletin of the World Health Organization 1998;76 Suppl 1:21-7.
Yeboah-Antwi 2001 {published and unpublished data}
  • Yeboah-Antwi K, Gyapong JO, Asare IK, Barnish G, Evans DB, Adjei S. Impact of prepackaging antimalarial drugs on cost to patients and compliance with treatment. Bulletin of the World Health Organization 2001;79(5):394-9.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Agyepong 2002 {published data only}
  • Agyepong IA, Ansah E, Gyapong M, Adjei S, Barnish G, Evans D. Strategies to improve adherence to recommended chloroquine treatment regimes: a quasi-experiment in the context of integrated primary health care delivery in Ghana. Social Science & Medicine 2002;55:2215-26.
Browne 2001 {unpublished data only}
  • Browne ENL, Hall-Baidu D, Sangber-Dery F, Owusu-Antwi F. Early appropriate management of fevers in children aged 6 months to 6 years in Ghana [unpublished]. World Health Organization TDR PROJECT No. 990614 2001.
Cullinan 1997 {published data only}
  • Cullinan TR, Pieterick C. Packaged treatment for first-line care in cerebral malaria and meningitis. Bulletin of the World Health Organization 1998;76(3):257-64.
Krudsood 2002 {published data only}
  • Krudsood S, Looareesuwan S, Silachamroon U, Chalermrut K, Pittrow D, Canbon N, et al. Artesunate and mefloquine given simultaneously for three days via a prepacked blister is equally effective and tolerated as a standard sequential treatment of uncomplicated acute Plasmodium falciparum malaria: randomized, double-blind study in Thailand. American Journal of Tropical Medicine and Hygiene 2002;67(5):465-72.
Okonkwo 2001 {published data only}
  • Okonkwo PO, Akpala CO, Okafor HU, Mbah AU, Nwaiwu O. Compliance to correct dose of chloroquine in uncomplicated malaria correlates with improvement in the condition of rural Nigerian children. Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(3):320-4.
Pagnoni 1997 {published data only}
  • Pagnoni F, Convelbo N, Tiendrebeogo J, Cousens S, Esposito F. A community-based programme to provide prompt and adequate treatment of presumptive malaria in children. Transactions of the Royal Society of Tropical Medicine and Hygiene 1997;91(5):512-7.
Shwe 1998 {published data only}
  • Shwe T, Lwin M, Aung S. Influence of blister packaging on the efficacy of artesunate + mefloquine over artesunate alone in community-based treatment of non-severe falciparum malaria in Myanmar. Bulletin of the World Health Organization 1998;76 Suppl 1:35-41.
Sirima 2003 {published data only}
  • Sirima SB, Konate A, Tiono AB, Convelbo N, Cousens S, Pagnoni F. Early treatment of childhood fevers with pre-packaged antimalarial drugs in the home reduces severe malaria morbidity in Burkina Faso. Tropical Medicine and International Health 2003;8(2):133-9.
    Direct Link:

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Alderson 2004
  • Alderson P, Green S, Higgins J, editors. Highly sensitive search strategy for identifying reports of randomized controlled trials in MEDLINE. Cochrane Reviewers' Handbook 4.2.2 [Updated March 2004]; Appendix 5b. http://www.cochrane.org/resources/handbook/hbook.htm (accessed 25 January 2005).
Becker 1986
  • Becker LA, Glanz K, Sobel E, Mossey J, Zinn SL, Knott KA. A randomized trial of special packaging of antihypertensive medications. Journal of Family Practice 1986;22(4):357-61.
Biritwum 2000
  • Biritwum RB, Welbeck J, Barnish G. Incidence and management of malaria in two communities of different socio-economic level, in Accra, Ghana. Annals of Tropical Medicine and Parasitology 2000;94(8):771-8.
Bloland 2003
Francis 1997
  • Francis F. The packaging of anti-malarials in Africa: communication issues [oral presentation]. The Tropical Diseases and Health Sector Reform Task Force Meeting, 10-12 September 1997, Liverpool.
Gomes 1998
  • Gomes M, Wayling S, Pang L. Interventions to improve the use of antimalarials in south-east Asia: an overview. Bulletin of the World Health Organization 1998;76 Suppl 1:9-19.
Haynes 1996
Haynes 2008
  • Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane Database of Systematic Reviews 2008, Issue 2. [Art. No.: CD000011. DOI: ]
Heneghan 2006
  • Heneghan CJ, Glasziou PP, Perera R. Reminder packaging for improving adherence to self-administered long-term medications. Cochrane Database of Systematic Reviews 2006, Issue Issue 1. [DOI: ]
Henry 1999
  • Henry A, Batey RG. Enhancing compliance not a prerequisite for effective eradication of Helicobacter pylori: the HelP Study. The American Journal of Gastroenterology 1999;94(3):811-5.
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Higgins 2008
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1. [Updated September 2008]. The Cochrane Collaboration, 2008.
Juni 2001
Kilian 2003
  • Kilian AHD, Tindyebwa D, Gulck T, Byamukama W, Rubaale T, Kabagambe G, et al. Attitude of women in western Uganda towards pre-packed, unit-dosed malaria treatment for children. Tropical Medicine and International Health 2003;8(5):431-8.
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Marsh 2004
  • Marsh VM, Mutemi WM, Willetts A, Bayah K, Were S, Ross A, et al. Improving malaria home treatment by training drug retailers in rural Kenya. Tropical Medicine and International Health 2004;9(4):451-60.
    Direct Link:
Mullen 1997
Ondari 2003
  • Ondari C. Personal communication 20 March 2003.
Peterson 1984
  • Peterson GM, McLean S, Millingen KS. A randomised trial of strategies to improve patient compliance with anticonvulsant therapy. Epilepsia 1984;25(4):412-7.
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RevMan 2008
  • The Nordic Cochrane Centre. The Cochrane Collaboration. Review Manager (RevMan). 5.0. Copenhagen: The Nordic Cochrane Centre. The Cochrane Collaboration, 2008.
Richardson 2003
  • Richardson, Edwards. Inc. A brief history of packaging. www.richanded.com/html/packaging_history.htm (accessed 18 September 2003).
Sackett 1979
  • Sackett DL, Snow JC. The magnitude of adherence and nonadherence. In: Haynes RB, Taylor DW, Sackett DL editor(s). Compliance in health care. Baltimore: John Hopkins University Press, 1979:11-22.
Standing 2004
Sumartojo 1993
Volmink 1997
White 1998
White 1999
WHO 1993
  • World Health Organization. A global strategy for malaria for malaria control. Geneva: World Health Organization, 1993.
WHO 2000
  • World Health Organization, Gilles HM. Management of severe malaria: a practical handbook. 2nd Edition. World Health Organization: Geneva, 2000.
WHO 2003
  • Malaria Control Department, World Health Organization. An update on quality assurance and procurement through WHO for improving access to artemisinin-based combination treatments (ACTs) for malaria. http://www.paho.org/English/AD/DPC/CD/mal-acts-update-7-03.pdf 2003 (accessed 11 November 2003).
WHO 2004
  • World Health Organization. The world health report 2004: changing history. World Health Organization: Geneva, 2004.
WHO 2006
  • World Health Organization. Guidelines for the treatment of malaria 2006.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Orton 2005
  • Orton L, Barnish G. Unit-dose packaged drugs for treating malaria. Cochrane Database of Systematic Reviews 2005, Issue 2. [Art. No.: CD004614. DOI: ]
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