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Mannitol and other osmotic diuretics as adjuncts for treating cerebral malaria

  1. Christy AN Okoromah2,*,
  2. Bosede B Afolabi3,
  3. Emma CB Wall4

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 13 APR 2011

Assessed as up-to-date: 22 NOV 2010

DOI: 10.1002/14651858.CD004615.pub3

How to Cite

Okoromah CAN, Afolabi BB, Wall ECB. Mannitol and other osmotic diuretics as adjuncts for treating cerebral malaria. Cochrane Database of Systematic Reviews 2011, Issue 4. Art. No.: CD004615. DOI: 10.1002/14651858.CD004615.pub3.

Author Information

  1. 2

    College of Medicine, University of Lagos, Department of Paediatrics and Child Health, Lagos, Lagos, Nigeria

  2. 3

    University of Lagos, Department of Obstetrics and Gynaecology, Lagos, Nigeria

  3. 4

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, UK

*Christy AN Okoromah, Department of Paediatrics and Child Health, College of Medicine University of Lagos, Idi-Araba, Surulere, Lagos, Lagos, PMB 12003, Nigeria. faimer2004_christy@yahoo.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 13 APR 2011

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References

References to studies included in this review

  1. References to studies included in this review
  2. Additional references
Namutangula 2007 {published and unpublished data}
  • Beatrice Namutangula, Grace Ndeezi, Justus S Byarugaba, James K Tumwine. Mannitol as adjunct therapy for childhood cerebral malaria in Uganda: a randomized clinical trial. Malaria Journal 2007;6:138.

Additional references

  1. References to studies included in this review
  2. Additional references
Alderson 2004
  • Alderson P, Green S, Higgins J, editors. Highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE. Cochrane Reviewer's Handbook 4.2.2 [updated March 2004]; Appendix 5b. In: The Cochrane Library. The Cochrane Collaboration. Chichester, UK: John Wiley & Sons, Ltd.; 2004, Issue 3.
Barnes 2009
  • Barnes K I, Chanda P, Ab Barnabas G. Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and Ethiopia. Malaria Journal 2009;8 Suppl 1:S8.
Bassat 2009
  • Bassat Q, Guinovart C, Sigauque B, Mandomando I, Aide P, Sacarlal J, et al. Severe malaria and concomitant bacteraemia in children admitted to a rural Mozambican hospital. Tropical Medicine and International Health 2009;14(9):1011-9.
Beare 2004
  • Beare N A, Southern C, Chalira C, Taylor T E, Molyneux M E, Harding S P. Prognostic significance and course of retinopathy in children with severe malaria. Archives of Ophthalmology 2004;122(8):1141-7.
Beare 2006
  • Beare N A, Riva C E, Taylor T E, Molyneux M E, Kayira K, White V A, et al. Changes in optic nerve head blood flow in children with cerebral malaria and acute papilloedema. Journal of Neurology, Neurosurgery and Psychiatry 2006;77(11):1288-90.
Bereczki 2007
  • Bereczki D, Liu M, Fernandes do Prado G, Fekete I. Mannitol for acute stroke. Cochrane Database of Systematic Reviews 2007, Issue 3. [Art. No.: CD001153. DOI: ]
Brain Trauma Foundation 2000
  • The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Initial management. Journal of Neurotrauma 2000;17(6-7):463-9.
Commey 1980
  • Commey JOO, Mills-Tetteh D, Phillips BJ. Cerebral malaria in Accra, Ghana. Ghana Medical Journal 1980;19:68-72.
De Vivo 1985
Grau 1989
  • Grau GE, Taylor TE, Molyneux ME, Wirima JJ, Vassalli P, Hommel M, et al. Tumor necrosis factor and disease severity in children with falciparum malaria. New England Journal of Medicine 1989;320(24):1586-91.
Ho 1998
  • Ho M, Schollaardt T, Snape S, Looareesuwan S, Suntharasamai P, White NJ. Endogenous interleukin-10 modulates proinflammatory response in Plasmodium falciparum malaria. Journal of Infectious Diseases 1998;178(2):520-5.
Ichai 2009
  • Ichai C, Armando G, Orban J C, Berthier F, Rami L, Samat-Long C, et al. Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients. Intensive Care Medicine 2009;35(3):471-9.
Jüni 2001
Kingston 1971
Krishna 1994
  • Krishna S, Waller D W, ter Kuile F, Kwiatkowski D, Crawley J, Craddock C F, et al. Lactic acidosis and hypoglycaemia in children with severe malaria: pathophysiological and prognostic significance. Transactions of the Royal Society of Tropical Medicine and Hygiene 1994;88(1):67-73.
Lesi 2004
  • Lesi F E, Okoromah C N. Management of children with cerebral malaria in Lagos - a medical audit. Nigerian Postgraduate Medical Journal 2004;11(4):286-9.
Looareesuwan 1995
  • Looareesuwan S, Wilairatana P, Krishna S, Kendall B, Vannaphan S, Viravan C, et al. Magnetic resonance imaging of the brain in patients with cerebral malaria. Clinical Infectious Disease 1995;21(2):300-9.
Looareesuwan 2009
  • Looareesuwan S, Laothamatas J, Brown T R, Brittenham G M. Cerebral malaria: a new way forward with magnetic resonance imaging (MRI). American Journal of Tropical Medicine and Hygiene 2009;81(4):545-7.
Maitland 2005
  • Maitland K, Pamba A, English M, Peshu N, Marsh K, Newton C, et al. Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit. Clinical Infectious Diseases 2005;40(4):538-45.
Mishra 2009
Mung'Ala-Odera 2004
  • Mung'Ala-Odera V, Snow R W, Newton C R. The burden of the neurocognitive impairment associated with Plasmodium falciparum malaria in sub-Saharan Africa. American Journal of Tropical Medicine and Hygiene 2004;71(2 Suppl):64-70.
Murphy 2001
  • Murphy SC, Breman JG. Gaps in the childhood malaria burden in Africa: cerebral malaria, neurological sequelae, anemia, respiratory distress, hypoglycemia, and complications of pregnancy. American Journal of Tropical Medicine and Hygiene 2001;64 Suppl 1-2:57-67.
Newton 1991
Newton 1994a
Newton 1994b
  • Newton CR. Intracranial hypertension in Kenyan children with cerebral malaria [MD thesis]. Cape Town: University of Cape Town, 1994.
Newton 1996
Newton 1997
Okoromah 2004
  • Okoromah C A, Afolabi B B. Mannitol and other osmotic diuretics as adjuncts for treating cerebral malaria. The Cochrane Database of Systematic Reviews 2004;18(4):CD004615.
Parmar 1998
  • Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Statistics in Medicine 1998;17(24):2815-34.
Patankar 2002
  • Patankar TF, Karnad DR, Shetty PG, Desal AP, Prasad SR. Adult cerebral malaria: prognostic importance of imaging findings and correlation with post-mortem findings. Radiology 2002;224(3):811-6.
Potchen 2009
  • Potchen M J, Birbeck G L, Demarco J K, Kampondeni S D, Beare N, Molyneux M E, et al. Neuroimaging findings in children with retinopathy-confirmed cerebral malaria. European Journal of Radiology 2009;74(1):262-8.
Prasad 2000
  • Prasad K, Garner P. Steroids for treating cerebral malaria. The Cochrane Database of Systematic Reviews 2000;2:CD000972.
Review Manager 5
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
Roca-Feltrer 2008
  • Roca-Feltrer A, Carneiro I, Armstrong Schellenberg J R. Estimates of the burden of malaria morbidity in Africa in children under the age of 5 years. Tropical Medicine and International Health 2008;13(6):771-83.
Rothe 1956
  • Rothe H. 100 cases of cerebral malaria. East African Medical Journal 1956;33(10):406-7.
Tomlinson 2003
Wakai 2007
  • Wakai A, Roberts I, Schierhout G. Mannitol for acute traumatic brain injury. The Cochrane Databse of Systematic Reviews 2007;24(1):CD001049.
Walker 1992
  • Walker O, Salako LA, Sowumni A, Thomas JO, Sodeinde O, Bondi FS. Prognostic risk factors and post mortem findings in cerebral malaria. Transactions of the Royal Society of Medicine and Hygiene 1992;86(5):491-3.
WHO 2000
  • Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Transactions of the Royal Society of Tropical Medicine and Hygiene 2000;94 Suppl 1:1-90.
WHO 2006
  • World Health Organization. World Health Organization guidelines for the treatment of malaria. Bulletin of the World Health Organization. World Health Organization, 2006, issue viii:1-253.