Intervention Review

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Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth

  1. Edmund Bailey1,*,
  2. Helen V Worthington2,
  3. Arjen van Wijk3,
  4. Julian M Yates1,
  5. Paul Coulthard1,
  6. Zahid Afzal4

Editorial Group: Cochrane Oral Health Group

Published Online: 12 DEC 2013

Assessed as up-to-date: 20 MAY 2013

DOI: 10.1002/14651858.CD004624.pub2


How to Cite

Bailey E, Worthington HV, van Wijk A, Yates JM, Coulthard P, Afzal Z. Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD004624. DOI: 10.1002/14651858.CD004624.pub2.

Author Information

  1. 1

    School of Dentistry, The University of Manchester, Department of Oral and Maxillofacial Surgery, Manchester, UK

  2. 2

    School of Dentistry, The University of Manchester, Cochrane Oral Health Group, Manchester, UK

  3. 3

    Academic Centre for Dentistry Amsterdam (ACTA), Social Dentistry and Behavioural Sciences, Amsterdam, Netherlands

  4. 4

    City Hospital, Oral and Maxillofacial Surgery, Birmingham, UK

*Edmund Bailey, Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Manchester, Coupland III Building, Oxford Road, Manchester, M13 9PL, UK. edmund.bailey@manchester.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 12 DEC 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Daniels 2009 {published data only}
  • Daniels S, Reader S, Berry P, Goulder M. Onset of analgesia with sodium ibuprofen, ibuprofen acid incorporating poloxamer and acetaminophen--a single-dose, double-blind, placebo-controlled study in patients with post-operative dental pain. European Journal of Clinical Pharmacology 2009;65(4):343-53.
Forbes 1990 {published data only}
  • Forbes JA, Kehm CJ, Grodin CD, Beaver WT. Evaluation of ketorolac, ibuprofen, acetaminophen, and an acetaminophen-codeine combination in postoperative oral surgery pain. Pharmacotherapy 1990;10(6 (Pt 2)):94S-105S.
Hersh 2000 {published data only}
Mehlisch 1995 {published data only}
  • Mehlisch DR, Jasper RD, Brown P, Korn SH, McCarroll K, Murakami AA. Comparative study of ibuprofen lysine and acetaminophen in patients with postoperative dental pain. Clinical Therapeutics 1995;17(5):852-60.
Mehlisch 2010 {published data only}
  • Mehlisch DR, Aspley S, Daniels SE, Bandy DP. Comparison of the analgesic efficacy of concurrent ibuprofen and paracetamol with ibuprofen or paracetamol alone in the management of moderate to severe acute postoperative dental pain in adolescents and adults: a randomized, double-blind, placebo-controlled, parallel-group, single-dose, two-center, modified factorial study. Clinical Therapeutics 2010;32(5):882-95.
Mehlisch 2010a {published data only}
  • Mehlisch DR, Aspley S, Daniels SE, Southerden KA, Christensen KS. A single-tablet fixed-dose combination of racemic ibuprofen/paracetamol in the management of moderate to severe postoperative dental pain in adult and adolescent patients: a multicenter, two-stage, randomized, double-blind, parallel-group, placebo-controlled, factorial study. Clinical Therapeutics 2010;32(6):1033-49.
Olson 2001 {published data only}
  • Olson NZ, Otero AM, Marrero I, Tirado S, Cooper S, Doyle G, et al. Onset of analgesia for liquigel ibuprofen 400 mg, acetaminophen 1000 mg, ketoprofen 25 mg, and placebo in the treatment of postoperative dental pain. Journal of Clinical Pharmacology 2001;41(11):1238-47.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bjornsson 2003 {published data only}
  • Bjornsson GA, Haanaes HR, Skoglund LA. A randomized, double-blind crossover trial of paracetamol 1000 mg four times daily vs ibuprofen 600 mg: effect on swelling and other postoperative events after third molar surgery. British Journal of Clinical Pharmacology 2003;55(4):405-12.
Chopra 2009 {published data only}
  • Chopra D, Rehan HS, Mehra P, Kakkar AK. A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. International Journal of Oral and Maxillofacial Surgery 2009;38(4):350-5.
Dionne 1983 {published data only}
  • Dionne RA, Campbell RA, Cooper SA, Hall DL, Buckingham B. Suppression of postoperative pain by preoperative administration of ibuprofen in comparison to placebo, acetaminophen, and acetaminophen plus codeine. Journal of Clinical Pharmacology 1983;23(1):37-43.
Ikeda 2002 {published data only}
  • Ikeda MC, Arrascue M, Carbajal L, Saravia MA. Ibuprofen, paracetamol and diclofenac plus paracetamol in third molar extractions - a double-blind post-operative study. Journal of Dental Research 2002;81(Spec Iss A):A-316 (Abstract no: 2510).
Merry 2010 {published data only}
  • Merry AF, Gibbs RD, Edwards J, Ting GS, Frampton C, Davies E, et al. Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial. British Journal of Anaesthesia 2010;104(1):80-8.
Ozkan 2010 {published data only}
  • Ozkan BT, Durmus E, Kalayci A, Kurban S, Akca CN. The evaluation of safety and analgesic efficacy of paracetamol and ibuprofen followed by impacted third molar surgery. European Journal of General Medicine 2010;7(3):310-6.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bentley 1987
Boers 2001
Bromley 2010
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Chandrasekharan 2002
  • Chandrasekharan NV, Dai H, Roos KLC, Evanson NK, Tomsik J, Elton TS, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure and expression. Proceedings of the National Academy of Sciences 2002;99(21):13926-31.
Collins 1999
  • Collins S, Moore RA, McQuay HJ, Wiffen PJ, Rees J, Derry S. Single dose oral ibuprofen for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 1999, Issue 1. [DOI: 10.1002/14651858.CD001548]
Colorado-Bonnin 2006
  • Colorado-Bonnin M, Valmaseda-Castellón E, Berini-Aytés L, Gay-Escoda C. Quality of life following lower third molar removal. International Journal of Oral and Maxillofacial Surgery 2006;35(4):343-7.
Conrad 1999
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Cooper 1976
Coulthard 1992
Coulthard 1993
Coulthard 2009
Daniels 2011
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Derry 2009
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Derry 2011
Derry 2013
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Dray 1997
Elbourne 2002
Fisher 1988
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Loeser 1999
Malmberg 1992
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Mehlisch 1990
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Mehlisch 2002
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Moore 1997a
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Moore 1998
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Neal 2012
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Savin 1997
  • Savin J, Ogden GR. Third molar surgery--a preliminary report on aspects affecting quality of life in the early postoperative period. British Journal of Oral and Maxillofacial Surgery 1997;35(4):246-53.
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Toms 2008
Weil 2007
  • Weil K, Hooper L, Afzal Z, Esposito M, Worthington HV, van Wijk A, et al. Paracetamol for pain relief after surgical removal of lower wisdom teeth. Cochrane Database of Systematic Reviews 2007, Issue 3. [DOI: 10.1002/14651858.CD004487.pub2]
Winter 1978