Zhiling decoction for vascular dementia
Editorial Group: Cochrane Dementia and Cognitive Improvement Group
Published Online: 16 JUL 2008
Assessed as up-to-date: 5 MAY 2008
Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
How to Cite
Jirong Y, Yang X, Wu T, Defen S, Dong B. Zhiling decoction for vascular dementia. Cochrane Database of Systematic Reviews 2004, Issue 4. Art. No.: CD004670. DOI: 10.1002/14651858.CD004670.pub2.
- Publication Status: New search for studies and content updated (no change to conclusions)
- Published Online: 16 JUL 2008
Zhiling decoction has a fixed composition of 15 Chinese herbs. The properties of each of these herbs and in combination provide the therapeutic rationale for a possible action of Zhiling decoction in dilating cerebral vessels and increasing cerebral blood flow, as well as reducing serum cholesterol. Thus the aim of this review is to evaluate efficacy and safety of Zhiling decoction for the treatment of vascular dementia.
To assess the efficacy and safety of Zhiling decoction for vascular dementia.
The Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (CDCIG), The Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL and LILACS were searched on 17 March 2008 using the term: zhiling. The CDCIG Specialized Register contains records from all major health care databases (The Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL, LILACS) as well as from many trials databases and grey literature sources.
Randomised trials comparing Zhiling decoction with placebo in people with vascular dementia.
Data collection and analysis
Two reviewers independently assessed trial quality and extracted data. Study authors were contacted for additional information. Adverse effects information was collected from the trials where possible.
In the absence of any suitable randomised placebo-controlled trials in this area, we were unable to perform a meta-analysis.
The currently available evidence is insufficient to assess the potential for Zhiling decoction in the treatment of vascular dementia. The little objective data concerning the management of Zhiling decoction versus Naofukang suggests that Zhiling decoction may be effective in treating vascular dementia.
There is no evidence for or against Zhiling as a treatment for vascular dementia. Further randomised, double-blind, placebo-controlled trials are urgently needed in order to define the relative efficacy and acceptability of Zhiling in vascular dementia.
Plain language summary
No evidence from randomised controlled trials for or against the use of Zhiling concoction in the treatment of people with vascular dementia
Zhiling is a decoction of 15 Chinese herbs which is thought to contribute to dilating cerebral vessels and increasing cerebral blood flow, as well as reducing serum cholesterol. No randomised controlled trials of Zhiling decoction versus placebo were found and thus its efficacy and safety could not be analysed in this review. There is a need for randomised placebo controlled trials of Zhiling decoction.
2006年6月7日使用Zhiling為關鍵字搜尋Cochrane Dementia and Cognitive Improvement Group Specialized Register資料庫。該資料庫含有所有主要健康照護資料庫的記錄及許多進行中臨床試驗資料庫的資料，且規律地更新。 此外，回顧者人工搜尋83種傳統中醫期刊，時間為1993年到2003年。
此翻譯計畫由臺灣國家衛生研究院(National Health Research Institutes, Taiwan)統籌。