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Fluoroquinolones for treating tuberculosis

  1. Lilia E Ziganshina1,*,
  2. Stephen B Squire2

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 21 JAN 2009

Assessed as up-to-date: 13 OCT 2007

DOI: 10.1002/14651858.CD004795.pub3

Database Title

Additional Information

How to Cite

Ziganshina LE, Squire SB. Fluoroquinolones for treating tuberculosis. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD004795. DOI: 10.1002/14651858.CD004795.pub3.

Author Information

  1. 1

    Kazan State Medical Academy, Department of Clinical Pharmacology and Pharmacotherapy, Kazan, Tatarstan, Russian Federation

  2. 2

    Liverpool School of Tropical Medicine, Clinical Group, Liverpool, Merseyside, UK

*Lilia E Ziganshina, Department of Clinical Pharmacology and Pharmacotherapy, Kazan State Medical Academy, 11 Mushtari Street, 420012, 14-15 Malaya Krasnaya Street, 420015, Kazan, Tatarstan, Russian Federation. lezign@mail.ru. lezign@gmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 JAN 2009

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ARTICLE TOOLS

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[Analysis 1.1]
Analysis 1.1. Comparison 1 Fluoroquinolone substituted into regimen, Outcome 1 Cure (sputum culture conversion) at 8 weeks.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Fluoroquinolone substituted into regimen, Outcome 2 Treatment failure at 12 months.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Fluoroquinolone substituted into regimen, Outcome 3 Relapse.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Fluoroquinolone substituted into regimen, Outcome 4 Relapse: by HIV status.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Fluoroquinolone substituted into regimen, Outcome 5 Time to sputum culture conversion (months).
[Analysis 1.6]
Analysis 1.6. Comparison 1 Fluoroquinolone substituted into regimen, Outcome 6 Time to sputum culture conversion (months): by HIV status.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Fluoroquinolone substituted into regimen, Outcome 7 Clinical or radiological improvement at 8 weeks.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Fluoroquinolone substituted into regimen, Outcome 8 Serious adverse events.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Fluoroquinolone substituted into regimen, Outcome 9 Total number of adverse events.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Fluoroquinolone substituted into regimen, Outcome 10 Total number of adverse events, substitutions for ethambutol.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Fluoroquinolone added to regimen, Outcome 1 Cure (sputum culture conversion) at 8 weeks.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Fluoroquinolone added to regimen, Outcome 2 Treatment failure at 12 months.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Fluoroquinolone added to regimen, Outcome 3 Clinical or radiological improvement at 8 weeks.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Fluoroquinolone added to regimen, Outcome 4 Death from any cause.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Fluoroquinolone added to regimen, Outcome 5 Tuberculosis-related death.
[Analysis 2.6]
Analysis 2.6. Comparison 2 Fluoroquinolone added to regimen, Outcome 6 Serious adverse events.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Comparison of fluoroquinolones (levofloxacin vs ofloxacin) substituted into regimen, Outcome 1 Cure (sputum culture conversion) within 2 to 3 weeks.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Comparison of fluoroquinolones (levofloxacin vs ofloxacin) substituted into regimen, Outcome 2 Treatment failure at 12 months.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Comparison of fluoroquinolones (levofloxacin vs ofloxacin) substituted into regimen, Outcome 3 Clinical or radiological improvement at 8 weeks.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Comparison of fluoroquinolones (levofloxacin vs ofloxacin) substituted into regimen, Outcome 4 Total number of adverse events.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Comparison of fluoroquinolones (sparfloxacin vs ofloxacin) added to regimens, Outcome 1 Cure (sputum culture conversion within 2 to 3 weeks).
[Analysis 4.2]
Analysis 4.2. Comparison 4 Comparison of fluoroquinolones (sparfloxacin vs ofloxacin) added to regimens, Outcome 2 Treatment failure at 12 months.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Comparison of fluoroquinolones (sparfloxacin vs ofloxacin) added to regimens, Outcome 3 Clinical or radiological improvement at 8 weeks.
[Analysis 4.4]
Analysis 4.4. Comparison 4 Comparison of fluoroquinolones (sparfloxacin vs ofloxacin) added to regimens, Outcome 4 Total number of adverse events.
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