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Interventions for American cutaneous and mucocutaneous leishmaniasis

  1. Urbà González 1,*,
  2. Mariona Pinart1,
  3. Mónica Rengifo-Pardo2,
  4. Antonio Macaya3,
  5. Jorge Alvar4,
  6. John A Tweed2

Editorial Group: Cochrane Skin Group

Published Online: 15 APR 2009

Assessed as up-to-date: 25 JAN 2009

DOI: 10.1002/14651858.CD004834.pub2

Database Title

Additional Information

How to Cite

González U, Pinart M, Rengifo-Pardo M, Macaya A, Alvar J, Tweed JA. Interventions for American cutaneous and mucocutaneous leishmaniasis. Cochrane Database of Systematic Reviews 2009, Issue 2. Art. No.: CD004834. DOI: 10.1002/14651858.CD004834.pub2.

Author Information

  1. 1

    Hospital Plató, Department of Dermatology, Research Unit for Evidence-based Dermatology, Barcelona, Catalunya, Spain

  2. 2

    University of Nottingham, c/o Cochrane Skin Group, Nottingham, UK

  3. 3

    Bellvitge Hospital, Barcelona, Fleixa Llarga s/n l'hospitalet de Llobregat, Barcelona, Spain

  4. 4

    World Health Organization, Control of Neglected Tropical Diseases (WHO/CDS/NTD/IDM), Geneva 27, Switzerland

*Urbà González , Department of Dermatology, Research Unit for Evidence-based Dermatology, Hospital Plató, c/ Plato 21, Barcelona, Catalunya, 08006, Spain. urba.gonzalez@hospitalplato.com .

Publication History

  1. Publication Status: New
  2. Published Online: 15 APR 2009

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ARTICLE TOOLS

View Full Article (HTML) Summary (64K)Standard (1040K)Full (1309K)
[Analysis 1.1]
Analysis 1.1. Comparison 1 IMMA (20 mg/kg/d for 20 d) vs placebo (3 tablets/4 times a day for 28 d) in L. braziliensis and L. panamensis; FU: 3 months and 1 year, Outcome 1 Complete cure.
[Analysis 2.1]
Analysis 2.1. Comparison 2 10-day IMMA versus 20-day IMMA in L. braziliensis and L. panamensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 2.2]
Analysis 2.2. Comparison 2 10-day IMMA versus 20-day IMMA in L. braziliensis and L. panamensis; FU: 1 year, Outcome 2 Adverse effects.
[Analysis 3.1]
Analysis 3.1. Comparison 3 IVMA 20 mg/kg/d for 15 d vs no treatment in L. panamensis; FU: 12 months, Outcome 1 Complete cure.
[Analysis 3.2]
Analysis 3.2. Comparison 3 IVMA 20 mg/kg/d for 15 d vs no treatment in L. panamensis; FU: 12 months, Outcome 2 Relapses.
[Analysis 4.1]
Analysis 4.1. Comparison 4 IVMA for 7 days + placebo topically TD for 10 d vs IVMA for 20 d in L. braziliensis & L. panamensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 5.1]
Analysis 5.1. Comparison 5 IVMA 15% (14 mg/kg/d) vs IVMA 30% (28 mg/kg/d) ; FU: 2 years, Outcome 1 Complete cure (CL plus MCL).
[Analysis 5.2]
Analysis 5.2. Comparison 5 IVMA 15% (14 mg/kg/d) vs IVMA 30% (28 mg/kg/d) ; FU: 2 years, Outcome 2 Complete cure CL form.
[Analysis 5.3]
Analysis 5.3. Comparison 5 IVMA 15% (14 mg/kg/d) vs IVMA 30% (28 mg/kg/d) ; FU: 2 years, Outcome 3 complete cure MCL form.
[Analysis 6.1]
Analysis 6.1. Comparison 6 10-day IVMA+ 10-day placebo versus 20-day IVMA in L. braziliensis and L. mexicana; FU: 1 year, Outcome 1 Complete cure.
[Analysis 7.1]
Analysis 7.1. Comparison 7 IMSSG 20 mg/kg/d for 20d vs IMMA (20 mg/kg/d for 20d) in L. panamensis; FU: 6 months, Outcome 1 Complete cure.
[Analysis 7.2]
Analysis 7.2. Comparison 7 IMSSG 20 mg/kg/d for 20d vs IMMA (20 mg/kg/d for 20d) in L. panamensis; FU: 6 months, Outcome 2 Adverse effects.
[Analysis 8.1]
Analysis 8.1. Comparison 8 IMSSG (branded) vs IMSSG (generic). Dose: 20 mg/kg/d for 20 d in L .panamensis; FU: 6 months, Outcome 1 Complete cure.
[Analysis 8.2]
Analysis 8.2. Comparison 8 IMSSG (branded) vs IMSSG (generic). Dose: 20 mg/kg/d for 20 d in L .panamensis; FU: 6 months, Outcome 2 Adverse effects.
[Analysis 9.1]
Analysis 9.1. Comparison 9 IVSSG for 28 days versus IVSSG for 40 days in L. braziliensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 10.1]
Analysis 10.1. Comparison 10 Oral ketoconazole for 28 days versus IMMA for 20 days in L. panamensis and L. mexicana; FU: 3 months, Outcome 1 Complete cure.
[Analysis 11.1]
Analysis 11.1. Comparison 11 Oral ketoconazole versus oral placebo for 28 days in L. panamensis and L. mexicana; FU: 3 months, Outcome 1 Complete cure.
[Analysis 12.1]
Analysis 12.1. Comparison 12 Oral AL 20 mg/kg/d (4 doses) for 15d vs. AL + IVMA (same regimen) in L. panamensis; FU: 12 months, Outcome 1 Complete cure.
[Analysis 12.2]
Analysis 12.2. Comparison 12 Oral AL 20 mg/kg/d (4 doses) for 15d vs. AL + IVMA (same regimen) in L. panamensis; FU: 12 months, Outcome 2 Relapses.
[Analysis 13.1]
Analysis 13.1. Comparison 13 Oral AL 20 mg/kg/d (4 doses) x 15d vs. IVMA (same regimen) in L. panamensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 13.2]
Analysis 13.2. Comparison 13 Oral AL 20 mg/kg/d (4 doses) x 15d vs. IVMA (same regimen) in L. panamensis; FU: 1 year, Outcome 2 Relapses.
[Analysis 14.1]
Analysis 14.1. Comparison 14 Oral AL + IVMA (20 mg/kg/d (4 doses) for 15d) vs. IVMA (same regimen) in L. panamensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 14.2]
Analysis 14.2. Comparison 14 Oral AL + IVMA (20 mg/kg/d (4 doses) for 15d) vs. IVMA (same regimen) in L. panamensis; FU: 1 year, Outcome 2 Relapses.
[Analysis 15.1]
Analysis 15.1. Comparison 15 Oral AL for 28d vs IMMA 20mg/kg/d for 20 d in L braziliensis and L. panamensis ; FU: 12 month, Outcome 1 Complete cure.
[Analysis 16.1]
Analysis 16.1. Comparison 16 Oral AL + IVSSG (20 mg/kg/d (4 doses) x 15d) vs IVSSG (same dose) in L. braziliensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 16.2]
Analysis 16.2. Comparison 16 Oral AL + IVSSG (20 mg/kg/d (4 doses) x 15d) vs IVSSG (same dose) in L. braziliensis; FU: 1 year, Outcome 2 Oral AL plus IV antimonials vs. IV antimonials.
[Analysis 17.1]
Analysis 17.1. Comparison 17 Oral AL + IVSSG (20 mg/kg/d (4 doses) for 28d) vs IVSSG (same dose); FU: 12 months, Outcome 1 Complete cure.
[Analysis 18.1]
Analysis 18.1. Comparison 18 Oral AL 20 mg/kg/d (4 doses) for 15 d vs no treatment in L. panamensis; FU: 12 months, Outcome 1 Complete cure.
[Analysis 18.2]
Analysis 18.2. Comparison 18 Oral AL 20 mg/kg/d (4 doses) for 15 d vs no treatment in L. panamensis; FU: 12 months, Outcome 2 Relapses.
[Analysis 19.1]
Analysis 19.1. Comparison 19 Oral AL 28 days versus placebo in L. braziliensis and L. panamensis; FU: 12 months, Outcome 1 Complete cure.
[Analysis 20.1]
Analysis 20.1. Comparison 20 Oral AL + IVMA (20 mg/kg/ d in 4 doses for 15d) vs no treatment in L. panamensis; FU: 12 months, Outcome 1 Complete cure.
[Analysis 20.2]
Analysis 20.2. Comparison 20 Oral AL + IVMA (20 mg/kg/ d in 4 doses for 15d) vs no treatment in L. panamensis; FU: 12 months, Outcome 2 Relapses.
[Analysis 21.1]
Analysis 21.1. Comparison 21 Oral miltefosine 50 mg for 28 d vs. placebo (same regimen) in L. mexicana, L. panamensis and L. braziliensis; FU: 6 months, Outcome 1 Complete cure.
[Analysis 21.2]
Analysis 21.2. Comparison 21 Oral miltefosine 50 mg for 28 d vs. placebo (same regimen) in L. mexicana, L. panamensis and L. braziliensis; FU: 6 months, Outcome 2 Adverse effects.
[Analysis 22.1]
Analysis 22.1. Comparison 22 Different regimens of IMAS in L. panamensis; FU: 1 year, Outcome 1 AS 12-g base x 7 days versus AS 12-g base x 14 days.
[Analysis 22.2]
Analysis 22.2. Comparison 22 Different regimens of IMAS in L. panamensis; FU: 1 year, Outcome 2 AS 12-g base x 7d versus AS 18-g base for 14 d.
[Analysis 22.3]
Analysis 22.3. Comparison 22 Different regimens of IMAS in L. panamensis; FU: 1 year, Outcome 3 AS 12-g base x 14 d versus AS 18-g base x 14 d.
[Analysis 23.1]
Analysis 23.1. Comparison 23 IMAS for 20 days versus IMMA for 20 days in L. braziliensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 23.2]
Analysis 23.2. Comparison 23 IMAS for 20 days versus IMMA for 20 days in L. braziliensis; FU: 1 year, Outcome 2 Adverse effects.
[Analysis 24.1]
Analysis 24.1. Comparison 24 IMAS for 20 days versus IMPI x 8 applications in L. braziliensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 24.2]
Analysis 24.2. Comparison 24 IMAS for 20 days versus IMPI x 8 applications in L. braziliensis; FU: 1 year, Outcome 2 Adverse effects.
[Analysis 25.1]
Analysis 25.1. Comparison 25 IM Aminosidine20 mg/kg/d for 28 d vs IVMA 20 mg/kg for 28 d; L. braziliensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 26.1]
Analysis 26.1. Comparison 26 IVPI for seven doses versus IVMA for 20 days in L. braziliensis; FU: 6 months, Outcome 1 Complete cure.
[Analysis 26.2]
Analysis 26.2. Comparison 26 IVPI for seven doses versus IVMA for 20 days in L. braziliensis; FU: 6 months, Outcome 2 Adverse effects.
[Analysis 27.1]
Analysis 27.1. Comparison 27 IMPI versus IMMA for 20 days in L. braziliensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 27.2]
Analysis 27.2. Comparison 27 IMPI versus IMMA for 20 days in L. braziliensis; FU: 1 year, Outcome 2 Adverse effects.
[Analysis 28.1]
Analysis 28.1. Comparison 28 Topical PR-MBCL TD for 20d vs placebo TD for 20d in L. panamensis and L. mexicana; FU: 12 months, Outcome 1 Complete cure.
[Analysis 29.1]
Analysis 29.1. Comparison 29 Topical PR-MBCL (TD x 10d) + IVMA x 7 d vs Placebo + IVMA x 7 d in L. braziliensis and L. panamensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 30.1]
Analysis 30.1. Comparison 30 Topical PR-MBCL (TD x 10d) + IVMA x 7 d vs PR-MBCL + IVMA x 3 d in L. braziliensis and L. panamensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 31.1]
Analysis 31.1. Comparison 31 Topical PR-MBCL (TD x 10d) + IVMA x 3 d vs Placebo + IVMA x 7 d in L. braziliensis and L. panamensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 32.1]
Analysis 32.1. Comparison 32 Topical PR-MBCL (TD x 10d) + IVMA x 7 d vs IVMA for 20 d in L. braziliensis and L. panamensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 33.1]
Analysis 33.1. Comparison 33 Topical PR-MBCL (TD x 10d) + IVMA x 3 d vs IVMA for 20 d in L. braziliensis and L. panamensis; FU: 1 year, Outcome 1 Complete cure.
[Analysis 34.1]
Analysis 34.1. Comparison 34 Vaccine vs IMMA (50 mg/kg in 2-3 series of 20 daily injections) in L. braziliensis; FU: 6 months, Outcome 1 Complete cure.
[Analysis 35.1]
Analysis 35.1. Comparison 35 BCG vs. IMMA in L. braziliensis; FU: 6 months, Outcome 1 Complete cure.
[Analysis 36.1]
Analysis 36.1. Comparison 36 Oral pentoxifylline 400 mg 3 times daily for 30d + IVSSG 20 mg/kg /d vs. placebo + IVSSG in L. braziliensis; FU: 4 months, Outcome 1 Complete cure.
[Analysis 37.1]
Analysis 37.1. Comparison 37 7.5% imiquimod cream x 20 days plus IVMA for 20 days versus IVMA x 20 days in L. braziliensis, L. peruviana, L. mexicana and L. amazonensis; FU: 3 months, Outcome 1 Complete cure.
[Analysis 38.1]
Analysis 38.1. Comparison 38 Topical imiquimod 5% + IVMA vs placebo + IM/IVMA in L. braziliensis and L. peruviana; FU: 1 year, Outcome 1 Complete cure.
[Analysis 38.2]
Analysis 38.2. Comparison 38 Topical imiquimod 5% + IVMA vs placebo + IM/IVMA in L. braziliensis and L. peruviana; FU: 1 year, Outcome 2 Adverse effects.
[Analysis 39.1]
Analysis 39.1. Comparison 39 7.5% imiquimod cream x 20 days versus IVMA x 20 days in L. braziliensis, L. peruviana, L. mexicana and L. amazonensis; FU: 3 months, Outcome 1 Complete cure.
[Analysis 40.1]
Analysis 40.1. Comparison 40 IVMA combined or in different regimens in L. braziliensis and L. mexicana; FU: 1 year, Outcome 1 10-day IV MA+10-day IFN-γ versus 10-day IV MA+10-day placebo.
[Analysis 40.2]
Analysis 40.2. Comparison 40 IVMA combined or in different regimens in L. braziliensis and L. mexicana; FU: 1 year, Outcome 2 10-day IV MA+ 10-day IFN-γ versus 20-day IV MA.
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