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Nutrient-enriched formula milk versus human breast milk for preterm infants following hospital discharge

  • Review
  • Intervention

Authors

  • Ginny Henderson,

    1. Griffith University, School of Nursing and Midwifery, South Brisbane, Queensland, Australia
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  • Tom Fahey,

    1. Royal College of Surgeons in Ireland Medical School, Department of Family Medicine and General Practice, Dublin, Ireland
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  • William McGuire

    Corresponding author
    1. Australian National University Medical School, Department of Paediatrics and Child Health, Canberra, ACT 2606, Australia
    • William McGuire, Department of Paediatrics and Child Health, Australian National University Medical School, Canberra Hospital Campus, Canberra, ACT 2606, Australia. william.mcguire@act.gov.au.

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Abstract

Background

Preterm infants are often growth-restricted at hospital discharge. Feeding infants after hospital discharge with nutrient-enriched formula milk instead of human breast milk might facilitate "catch-up" growth and improve development.

Objectives

To determine the effect of feeding nutrient-enriched formula compared with human breast milk on growth and development of preterm infants following hospital discharge.

Search methods

The standard search strategy of the Cochrane Neonatal Review Group was used. This included searches of the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 2, 2007), MEDLINE (1966 - May 2007), EMBASE (1980 - May 2007), CINAHL (1982 - May 2007), conference proceedings, and previous reviews.

Selection criteria

Randomised or quasi-randomised controlled trials that compared feeding preterm infants following hospital discharge with nutrient-enriched formula compared with human breast milk.

Data collection and analysis

The standard methods of the Cochrane Neonatal Review Group were used, with separate evaluation of trial quality and data extraction by two review authors.

Main results

No eligible trials were identified.

Authors' conclusions

There are no data from randomised controlled trials to determine whether feeding preterm infants following hospital discharge with nutrient-enriched formula milk versus human breast milk affects growth and development. Mothers who wish to breast feed, and their health care advisors, would require very clear evidence that feeding with a nutrient-enriched formula milk had major advantages for their infants before electing not to feed (or to reduce feeding) with maternal breast milk. If evidence from trials that compared feeding preterm infants following hospital discharge with nutrient-enriched versus standard formula milk demonstrated an effect on growth or development, then this might strengthen the case for undertaking trials of nutrient-enriched formula milk versus human breast milk.

摘要

背景

早產兒在出院後使用加強營養的配方奶或母奶

早產兒通常在出院後仍呈現生長受限的狀態。餵哺出院後的早產兒加強營養的配方奶來取代母奶,也許可以加速其成長及改善發展。

目標

為了決定餵哺加強營養配方奶及母奶在出院後早產兒的生長及發展上的影響。

搜尋策略

使用Cochrane Neonatal Review Group的標準搜尋策略。這包括搜尋Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 2, 2007), MEDLINE (1966  May 2007), EMBASE (1980 May 2007), CINAHL (1982  May 2007), 會議記錄及之前的回顧文章。

選擇標準

選擇有關餵哺出院後早產兒加強營養配方奶或母奶之隨機分配或半隨機分配的文章。

資料收集與分析

使用Cochrane Neonatal Review Group的標準方法,藉兩位回顧文章作者來分開評估其研究品質及資料的選取。

主要結論

無符合標準的試驗。

作者結論

沒有關於餵哺出院後早產兒營養加強配方奶或是母奶,影響其生長或發展的隨機分配試驗。想要餵哺母奶的媽媽及他們的健康照護提供者,也許在選擇不餵哺母奶或減少餵哺母奶之前,需要明確的證據證明餵哺加強營養配方奶對他們的寶寶是有好處的。假如研究中的證據顯示餵食營養加強配方奶比標準配方奶有較好的生長發展,那麼更加強了研究營養加強配方奶和母奶差異的必要性。

翻譯人

本摘要由馬偕醫院曾至凡翻譯。

此翻譯計畫由臺灣國家衛生研究院 (National Health Research Institutes, Taiwan) 統籌。

總結

當出院回家時,早產兒通常比足月兒小很多。這回顧想證明在這些嬰兒餵哺加強營養配方奶比哺餵母奶有較好的生長及發展。搜尋後找不到關於此類的試驗,而早產兒的母親是否願意接受此類臨床試驗仍屬未知。

Plain language summary

Nutrient-enriched formula milk versus human breast milk for preterm infants following hospital discharge

Preterm infants are often much smaller than term infants by the time that they are discharged home from hospital. This review sought evidence that feeding these infants with nutrient-enriched formula milk rather than breast milk would increase growth rates and benefit development. No trials of this intervention were found. Whether undertaking such trials would be acceptable to mothers of preterm infants is not known.