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Intervention Review

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Antifibrinolytic drugs for acute traumatic injury

  1. Ian Roberts1,*,
  2. Haleema Shakur2,
  3. Katharine Ker1,
  4. Tim Coats3,
  5. on behalf of the CRASH-2 Trial collaborators2

Editorial Group: Cochrane Injuries Group

Published Online: 12 DEC 2012

Assessed as up-to-date: 14 JUL 2010

DOI: 10.1002/14651858.CD004896.pub3


How to Cite

Roberts I, Shakur H, Ker K, Coats T, on behalf of the CRASH-2 Trial collaborators. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database of Systematic Reviews 2012, Issue 12. Art. No.: CD004896. DOI: 10.1002/14651858.CD004896.pub3.

Author Information

  1. 1

    London School of Hygiene & Tropical Medicine, Cochrane Injuries Group, London, UK

  2. 2

    London School of Hygiene & Tropical Medicine, Clinical Trials Unit, London, UK

  3. 3

    Leicester Royal Infirmary, Department of Emergency Medicine, Leicester, UK

*Ian Roberts, Cochrane Injuries Group, London School of Hygiene & Tropical Medicine, North Courtyard, Keppel Street, London, WC1E 7HT, UK. Ian.Roberts@Lshtm.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 12 DEC 2012

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This is not the most recent version of the article. View current version (09 MAY 2015)

[Analysis 1.1]
Analysis 1.1. Comparison 1 Tranexamic acid versus placebo, Outcome 1 All-cause mortality.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Tranexamic acid versus placebo, Outcome 2 Proportion undergoing surgical intervention.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Tranexamic acid versus placebo, Outcome 3 Proportion receiving blood transfusion.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Tranexamic acid versus placebo, Outcome 4 Volume of blood transfused.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Aprotinin versus placebo, Outcome 1 Death.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Aprotinin versus placebo, Outcome 2 Proportion undergoing surgical intervention.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Aprotinin versus placebo, Outcome 3 Volume of blood transfused.