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Multiple-micronutrient supplementation for women during pregnancy

  1. Batool A Haider,
  2. Zulfiqar A Bhutta*

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 18 OCT 2006

Assessed as up-to-date: 7 AUG 2006

DOI: 10.1002/14651858.CD004905.pub2


How to Cite

Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database of Systematic Reviews 2006, Issue 4. Art. No.: CD004905. DOI: 10.1002/14651858.CD004905.pub2.

Author Information

  1. The Aga Khan University Hospital, Department of Paediatrics & Child Health, Karachi, Pakistan

*Zulfiqar A Bhutta, Department of Paediatrics & Child Health, The Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi, 74800, Pakistan. zulfiqar.bhutta@aku.edu.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 18 OCT 2006

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This is not the most recent version of the article. View current version (13 APR 2017)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Bangladesh 2002 {unpublished data only}
  • Anonymous. Multiple micronutrient supplementation of women during pregnancy. Data on file.
Christian 2003 {published data only}
  • Christian P, Khatry SK, Katz J, Pradhan EK, LeClerq SC, Shrestha SR, et al. Effects of alternative maternal micronutrient supplements on low birth weight in rural Nepal: double blind randomised community trial. BMJ 2003;326:571.
  • Christian P, Shrestha J, LeClerq SC, Khatry SK, Jiang T, Wagner T, et al. Supplementation with micronutrients in addition to iron and folic acid does not further improve the hematologic status of pregnant women in rural Nepal. Journal of Nutrition 2003;133:3492-8.
  • Christian P, West KP Jr, Khatry SK, LeClerq SC, Pradhan EK, Katz J, et al. Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomised trial in Nepal. American Journal of Clinical Nutrition 2003;78:1194-202.
Dieckmann 1943 {published data only}
  • Dieckmann WJ, Adair FL, Michel H, Kramer S, Dunkle F, Arthur B, et al. Calcium, phosphorus, iron and nitrogen balances in pregnant women. American Journal of Obstetrics and Gynecology 1943;47:357-68.
Friis 2004 {published data only}
  • Friis H, Gomo E, Nyazema N, Ndhlovu P, Krarup H, Kaestel P, et al. Effect of micronutrient supplementation on gestational length and birth size: a randomized, placebo-controlled, double-blind effectiveness trial in Zimbabwe. American Journal of Clinical Nutrition 2004;80:178-84.
Guinea-Bissau 2003 {unpublished data only}
  • Anonymous. Multiple micronutrient supplementation in pregnancy. Data on file.
Osrin 2005 {published data only}
  • Osrin D, Vaidya A, Shrestha Y, Baniya RB, Manandhar DS, Adhikari RK, et al. Effects of antenatal micronutrient supplementation on birthweight and gestational duration in Nepal: double-blind, randomised controlled trial. Lancet 2005;365:955-62.
Pakistan 2002 {unpublished data only}
  • Anonymous. Multiple micronutrient supplementation in pregnancy. Data on file.
Ramakrishnan 2003 {published data only}
  • Ramakrishnan U, Gonzalez-Cossio T, Neufeld LM, Rivera J, Martorell R. Multiple micronutrient supplementation during pregnancy does not lead to greater infant birth size than does iron-only supplementation: a randomized controlled trial in a semirural community in Mexico. American Journal of Clinical Nutrition 2003;77:720-5.
  • Ramakrishnan U, Neufeld LM, Gonzalez-Cossio T, Villalpando S, Garcia-Guerrra A, Juan R, et al. Multiple micronutrient supplements during pregnancy do not reduce anemia or improve iron status compared to iron-only supplements in semirural Mexico. Journal of Nutrition 2004;134:898-903.
Tatala 2002 {published data only}
  • Makola D, Ask DM, Tatala SR, Latham MC, Ndossi G, Mehansho H. A micronutrient-fortified beverage prevents iron deficiency, reduces anemia and improves the hemoglobin concentration in pregnant tanzanian women. Journal of Nutrition 2003;133:1339-46.
  • Tatala SR, Ash D, Makola D, Latham M, Ndosi G, Grohn Y. Effect of micronutrient fortified beverage on nutritional anaemia during pregnancy. East African Medical Journal 2002;79(11):598-603.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
An 2001 {published data only}
  • An H, Yin S, Xu Q. Effects of supplementing calcium, iron and zinc on the fetus development and growth during pregnancy. Zhonghua Yu Fang Yi Xue Za Zhi 2001;35(6):370-3.
Beazley 2002 {published data only}
  • Beazley D, Ahokas R, Livingston J, Griggs M, Scroggs A, Sibai B. Effects of vitamin C and E supplementation on total antioxidant status (TAS) and 8-isoprostane (IP) levels is women at high risk for preeclampsia. American Journal of Obstetrics and Gynecology 2002;187(6 Pt 2):S76.
  • Beazley D, Livingston J, Kao L, Sibai B. Vitamin C and E supplementation in women at high risk for preeclampsia: a double blind placebo controlled trial. American Journal of Obstetrics and Gynecology 2002;187(6 Pt 2):S216.
Biswas 1984 {published data only}
  • Biswas MK, Pernoll MJ, Mabie WC. A placebo controlled comparative trial of various prenatal vitamin formulations in pregnant women. Clinical Therapeutics 1984;6(6):763-9.
Caulfield 1999 {published data only}
  • Caulfield L, Zavaleta N, Figueroa A, Leon Z. Maternal zinc supplementation does not affect birth size or pregnancy duration in Peru. Journal of Nutrition 1999;129:1563-8.
  • Caulfield LE, Zavaleta N, Figueroa A. Adding zinc to prenatal iron and folate supplements improves maternal and neonatal zinc status in a Peruvian population. American Journal of Clinical Nutrition 1999;69:1257-63.
Chames 2002 {published data only}
  • Chames M, Liu H, Bendich A, Bogden J, Siabi B, Prada J. A randomized trial of calcium supplementation: effects on blood lead levels in pregnancy. American Journal of Obstetrics and Gynecology 2002;187(6 Pt 2):S137.
Christian 2001 {published data only}
  • Christian P, Khatry SK, Yamini S, Stallings R, LeClerq SC, Shrestha SR, et al. Zinc supplementation might potentiate the effect of vitamin A in restoring night vision in pregnant Nepalese women. American Journal of Clinical Nutrition 2001;73:1045-51.
Czeizel 1996 {published data only}
Dawson 1987 {published data only}
Dawson 1998 {published data only}
  • Dawson EB, Dawson R, Behrens J, DeVora M, McGanity WJ. Iron in prenatal multivitamin / multimineral supplements. Journal of Reproductive Medicine 1998;43:133-40.
Fawzi 1998 {published data only}
  • Fawzi WW, Msamanga GI, Spiegelman D, Urassa EJN, McGarth N, Mwakagile D, et al. Randomized controlled trial of the effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV -1 infected women in Tanzania. Lancet 1998;351:1477-82.
Fawzi 2000 {published data only}
  • Fawzi WW, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, et al. Randomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania. Journal of Acquired Immune Deficiency Syndromes 2000;23(3):246-54.
Fawzi 2004 {published data only}
  • Fawzi W, Msamanga G, Antelman G, Xu C, Hertzmark E, Spiegelman D, et al. Effect of prenatal vitamin supplementation on lower genital levels of HIV type 1 and interleukin type 1 beta at 36 weeks of gestation. Clinical Infectious Diseases 2004;38(5):716-22.
Fawzi 2004a {published data only}
  • Fawzi WW, Msamanga G, Spiegelman D, Wei R, Kapiga S, Villamor E, et al. A randomised trial of multivitamin supplements and HIV disease progression and mortality. New England Journal of Medicine 2004;351(1):23-32.
Fleming 1986 {published data only}
  • Fleming AF, Ghatoura GBS, Harrison KA, Briggs ND, Dunn DT. The prevention of anemia in pregnancy in primigravidae in the guinea savana of Nigeria. Annals of Tropical Medicine and Parasitology 1986;80(2):211-33.
Garg 1994 {published data only}
  • Garg HK, Singhal KC, Arshad Z. Effect of oral zinc supplementation on copper and haemoglobin levels in pregnant women. Indian Journal of Physiology and Pharmacology 1994;38(4):272-6.
Goldenberg 1995 {published data only}
Guldholt 1991 {published data only}
Haibin 2001 {published data only}
  • Haibin AN, Shi'an YIN, Qingmei XU, et al. Effects of calcium, iron and zinc on fetus development and growth during pregnancy. Chinese Journal of Preventive Medicine 2001;35(6):370-3.
Harrison 1985 {published data only}
  • Harrison KA, Fleming AF, Briggs ND, Rossiter CE. Growth during pregnancy in Nigerian teenage primigravidae. British Journal of Obstetrics and Gynaecology 1985;92(Suppl 5):32-9.
Hillman 1963 {published data only}
Hininger 2004 {published data only}
  • Hininger I, Favier M, Arnaud J, Faure H, Thoulon JM, Hariveau E, et al. Effects of a combined micronutrient supplementation on maternal biological status and newborn anthropometric measurements: a randomized double-blind, placebo-controlled trial in apparently healthy pregnant women. European Journal of Clinical Nutrition 2004;58:52-9.
Holly 1955 {published data only}
Hunt 1983 {published data only}
  • Hunt IF, Murphy NJ, Cleaver AE, Fardji B, Swendseid ME, Coulson AH, et al. Zinc supplementation during pregnancy: effects on selected blood constituents and on progress and outcome of pregnancy in low-income women of Mexican descent. American Journal of Clinical Nutrition 1984;40:508-21.
  • Hunt IF, Murphy NJ, Cleaver AE, Fardji B, Swendseid ME, Coulson AH, et al. Zinc supplementation during pregnancy: zinc concentration of serum and hair from low income women of Mexican descent. American Journal of Clinical Nutrition 1983;37:572-82.
Hunt 1985 {published data only}
  • Hunt IF, Murphy NJ, Cleaver AE, Fardji B, Swendseid ME, Browdy BL, et al. Zinc supplementation during pregnancy in low-income teenagers of Mexican descent: effects on selected blood constituents and on progress and outcome of pregnancy. American Journal of Clinical Nutrition 1985;42:815-28.
ICMR 2000 {published data only}
  • Indian Council of Medical Research (ICMR) Collaborating Centers, Central Technical Co-ordinating Unit. Multicentric study of efficacy of periconceptional folic acid containing vitamin supplementation in prevention of open neural tube defects in India. Indian Journal of Medical Research 2000;112:206-11.
Marya 1987 {published data only}
Mathan 1979 {published data only}
  • Mathan VI, Baker SJ, Sood SK, Ramachandran K, Ramalingaswami V. WHO sponsored collaborative studies on nutritional anaemia in India. The effects of ascorbic acid and protein supplementation on the response of pregnant women to iron, pteroylglutamic acid and cyanocobalamin therapy. British Journal of Nutrition 1979;42:391-8.
Menon 1962 {published data only}
  • Menon MKK, Rajan L. Prophylaxis of anaemia in pregnancy. British Journal of Obstetrics and Gynaecology of the British Commonwealth 1962;12:382-9.
Merchant 2005 {published data only}
  • Merchant AT, Msamanga G, Villamor E, Saathoff E, O'Brien M, Hertzmark E, et al. Multivitamin supplementation of HIV- positive women during preganncy reduces hypertension. Journal of Nutrition 2005;135(7):1776-81.
Merialdi 1998 {published data only}
  • Merialdi M, Caulfield LE, Zavaleta N, Figueroa A, DiPietro JA. Adding zinc to prenatal iron and folate tablets improves fetal neurobehavioral development. American Journal of Obstetrics and Gynecology 1998;180:483-90.
Muslimatun 2001 {published data only}
  • Muslimatun S, Schmidt MK, Schultink W, West CE, Hautvast JGAJ, Gross R. Weekly supplementation with iron and vitamin A during pregnancy increases hemoglobin concentration but decreases serum ferritin concentration in Indonesian pregnant women. Journal of Nutrition 2001;131(1):85-90.
  • Muslimatun S, Schmidt MK, West CE, Schultink W, Hautvast JGAJ, Karyadi D. Weekly vitamin A and iron supplementation during pregnancy increases vitamin A concentration of breast milk but not iron status in Indonesian lactating women. Journal of Nutrition 2001;131:2664-9.
Robertson 1991 {published data only}
Schmidt 2001 {published data only}
  • Schmidt MK, Muslimatun S, West CE, Schultink W, Hautvast JGAJ. Vitamin A and iron supplementation of Indonesian pregnant women benefits vitamin A status of their infants. British Journal of Nutrition 2001;86:607-15.
Schmidt 2002 {published data only}
  • Schmidt MK, Muslimatun S, Schultink W, West CE, Hautvast JGAJ. Randomized double blind trial of the effect of vitamin A supplementation of Indonesian pregnant women on morbidity and growth of their infants during the first year of life. European Journal of Clinical Nutrition 2002;56:338-46.
Schmidt 2004 {published data only}
  • Schmidt MK, Muslimatun S, West CE, Schultink W, Hautvast JG. Mental and psychomotor development in Indonesian infants of mothers supplemented with vitamin A in addition to iron during pregnancy. British Journal of Nutrition 2004;91(2):279-85.
Semba 2001 {published data only}
Sood 1975 {published data only}
  • Sood SK, Ramachandran K, Mathur M, Gupta K, Ramalingaswami V, Swarnbai C, et al. WHO sponsored collaborative study on nutritional anemia in India. Quarterly Journal of Medicine, New Series XLIV 1975;174:241-58.
Suharno 1993 {published data only}
Suprapto 2002 {published data only}
Tanumihardjo 2002 {published data only}
  • Tanumihardjo SA. Vitamin A and iron status are improved by vitamin A and iron supplementation in pregnant Indonesian women. Journal of Nutrition 2002;132:1909-12.
Thauvin 1992 {published data only}
  • Thauvin E, Fusselier M, Arnaud J, Faure H, Favier M, Coudray C, et al. Effects of multivitamin mineral supplement on zinc and copper status during pregnancy. Biological Trace Element Research 1992;32:405-14.
Villamor 2002 {published data only}
  • Villamor E, Msamanga G, Spiegelman D, Antelman G, Peterson KE, Hunter DJ, et al. Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1 infected women. American Journal of Clinical Nutrition 2002;76:1082-90.
Villamor 2005 {published data only}
  • Villamor E, Saathoff E, Bosch RJ, Hertzmark E, Baylin A, Manji K, et al. Vitamin supplementation of HIV-infected women improves postnatal child growth. American Journal of Clinial Nutrition 2005;81(4):880-8.
Zavaleta 2000 {published data only}
  • Zavaleta N, Caulfield LE, Garcia T. Changes in iron status during pregnancy in Peruvian women receiving prenatal iron and folic acid supplements with or without zinc. American Journal of Clinical Nutrition 2000;71:956-61.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Kubik 2004 {published data only}
  • Kubik P, Kowalska B, Laskowska-Klita T, Chelchowska M, Leibschang J. Effect of vitamin-mineral supplementation on the status of some microelements in pregnant women. Przeglad Lekarski 2004;61(7):764-8.
Ling 1996 {published data only}
  • Ling CD, Zhang ZJ, Chen ZL. Studies on nutritional effects of traditional Chinese tonics with strengthened nutrients on pregnant women and rats. Chung-Kuo Chung Hsi i Chieh Ho Tsa Chih 1996;16:270-3.
People's League 1942 {published data only}
  • People's League of Health. Nutrition of expectant and nursing mothers: interim report. Lancet 1942;2:10-2.
  • Peoples League of Health. The nutrition of expectant and nursing mothers in relation to maternal and infant mortality and morbidity. Journal of Obstetrics and Gynaecology of the British Empire 1946;53:498-509.

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  3. References to studies awaiting assessment
  4. Additional references
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