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Multiple-micronutrient supplementation for women during pregnancy

  1. Batool A Haider1,
  2. Zulfiqar A Bhutta2,*

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 14 NOV 2012

Assessed as up-to-date: 17 FEB 2012

DOI: 10.1002/14651858.CD004905.pub3


How to Cite

Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD004905. DOI: 10.1002/14651858.CD004905.pub3.

Author Information

  1. 1

    Harvard School of Public Health, Departments of Epidemiology and Nutrition, Boston, MA, USA

  2. 2

    Aga Khan University Hospital, Division of Women and Child Health, Karachi, Pakistan

*Zulfiqar A Bhutta, Division of Women and Child Health, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi, 74800, Pakistan. zulfiqar.bhutta@aku.edu.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 14 NOV 2012

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This is not the most recent version of the article. View current version (13 APR 2017)

[Figure 1]
Figure 1. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Funnel plot of comparison: 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), outcome: 1.1 Preterm births.
[Figure 4]
Figure 4. Funnel plot of comparison: 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), outcome: 1.2 Small-for-gestational age.
[Figure 5]
Figure 5. Funnel plot of comparison: 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), outcome: 1.6 Low birthweight.
[Figure 6]
Figure 6. Funnel plot of comparison: 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), outcome: 1.13 Perinatal mortality.
[Figure 7]
Figure 7. Funnel plot of comparison: 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), outcome: 1.14 Stillbirths.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 1 Preterm births.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 2 Small-for-gestational age.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 3 Small-for-gestational age: maternal BMI.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 4 Small for gestational age: maternal height.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 5 Small-for-gestational age: supplementation.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 6 Low birthweight.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 7 Low birthweight: maternal BMI.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 8 Low birthweight: maternal height.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 9 Low birthweight: supplementation.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 10 Pre-eclampsia.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 11 Miscarriage (loss before 28 weeks).
[Analysis 1.12]
Analysis 1.12. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 12 Maternal mortality.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 13 Perinatal mortality.
[Analysis 1.14]
Analysis 1.14. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 14 Stillbirths.
[Analysis 1.15]
Analysis 1.15. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 15 Neonatal mortality.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 16 Maternal anaemia (third trimester Hb < 110 g/L).
[Analysis 1.17]
Analysis 1.17. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 17 Placental abruption.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 18 Very preterm birth (before 34 weeks of gestation).
[Analysis 1.19]
Analysis 1.19. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 19 Side effects of supplements.
[Analysis 1.20]
Analysis 1.20. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 20 Congenital anomalies (including neural tube defects).
[Analysis 1.21]
Analysis 1.21. Comparison 1 Multiple micronutrients versus controls (no supplements, placebo or two or less than two micronutrients), Outcome 21 Neurodevelopmental outcome: BSID scores.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 1 Preterm births.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 2 Small-for-gestational age.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 3 Small-for-gestational age: maternal BMI.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 4 Small-for-gestational age: maternal height.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 5 Small-for-gestational age: supplementation.
[Analysis 2.6]
Analysis 2.6. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 6 Low birthweight.
[Analysis 2.7]
Analysis 2.7. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 7 Low birthweight: maternal BMI.
[Analysis 2.8]
Analysis 2.8. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 8 Low birthweight: maternal height.
[Analysis 2.9]
Analysis 2.9. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 9 Low birthweight: supplementation.
[Analysis 2.10]
Analysis 2.10. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 10 Pre-eclampsia.
[Analysis 2.11]
Analysis 2.11. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 11 Miscarriage (loss before 28 weeks).
[Analysis 2.12]
Analysis 2.12. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 12 Maternal mortality.
[Analysis 2.13]
Analysis 2.13. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 13 Perinatal mortality.
[Analysis 2.14]
Analysis 2.14. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 14 Perinatal mortality: maternal BMI.
[Analysis 2.15]
Analysis 2.15. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 15 Perinatal mortality: maternal height.
[Analysis 2.16]
Analysis 2.16. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 16 Perinatal mortality: supplementation.
[Analysis 2.17]
Analysis 2.17. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 17 Stillbirths.
[Analysis 2.18]
Analysis 2.18. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 18 Neonatal mortality.
[Analysis 2.19]
Analysis 2.19. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 19 Maternal anaemia (third trimester Hb <110 g/L).
[Analysis 2.20]
Analysis 2.20. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 20 Very preterm birth (before 34 weeks of gestation).
[Analysis 2.21]
Analysis 2.21. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 21 Side effects.
[Analysis 2.22]
Analysis 2.22. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 22 Congenital anomalies.
[Analysis 2.23]
Analysis 2.23. Comparison 2 Multiple micronutrients versus iron folate only, Outcome 23 Neurodevelopmental outcome: BSID scores.