Intervention Protocol

Statins for preventing major vascular events in people with hypertension

  1. Guido Rosito1,*,
  2. Airton T Stein2

Editorial Group: Cochrane Hypertension Group

Published Online: 8 DEC 2010

Assessed as up-to-date: 8 NOV 2010

DOI: 10.1002/14651858.CD004933.pub2


How to Cite

Rosito G, Stein AT. Statins for preventing major vascular events in people with hypertension (Protocol). Cochrane Database of Systematic Reviews 2010, Issue 12. Art. No.: CD004933. DOI: 10.1002/14651858.CD004933.pub2.

Author Information

  1. 1

    Porto Alegre, Brazil

  2. 2

    Universidade Federal de Ciências da Saúde, Department of Public Health, Porto Alegre, Brazil

*Guido Rosito, Rua Dr Vale 651/902, Porto Alegre, 90560-010, Brazil. guidorosito@cpovo.net.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 8 DEC 2010

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary Objective

To determine if statins, as compared to placebo or no treatment, reduce major vascular endpoints (such as total and cardiovascular mortality, stroke and myocardial infarction) in patients with elevated blood pressure.

Secondary Objectives

To determine the magnitude of the effect of statins on systolic and diastolic blood pressure in patients with elevated blood pressure.
To determine the magnitude of the effect of statin on plasma lipids (total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides) in patients with elevated blood pressure.
To determine the rate of withdrawal due to adverse effects with statins as compared to placebo or no treatment in patients with elevated blood pressure.