Intervention Review

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Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media

  1. Sanguansak Thanaviratananich1,*,
  2. Malinee Laopaiboon2,
  3. Patravoot Vatanasapt1

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 13 DEC 2013

Assessed as up-to-date: 15 MAR 2013

DOI: 10.1002/14651858.CD004975.pub3


How to Cite

Thanaviratananich S, Laopaiboon M, Vatanasapt P. Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD004975. DOI: 10.1002/14651858.CD004975.pub3.

Author Information

  1. 1

    Faculty of Medicine, Khon Kaen University, Department of Otorhinolaryngology, Khon Kaen, Thailand

  2. 2

    Khon Kaen University, Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen, Thailand

*Sanguansak Thanaviratananich, Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, 123 Friendship Road, Khon Kaen, 40002, Thailand. sthanaviratananich@gmail.com. sanguansak2011@gmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions), comment added to review
  2. Published Online: 13 DEC 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Behre 1997 {published data only (unpublished sought but not used)}
  • Behre U, Burow HM, Quinn P, Cree F, Harrison HE. Efficacy of twice-daily dosing of amoxycillin/clavulanate in acute otitis media in children. Infection 1997;25(3):163-6.
Damrikarnlert 2000 {published and unpublished data}
  • Damrikarnlert L, Jauregui AC, Kzadri M. Efficacy and safety of amoxycillin/clavulanate (Augmentin) twice daily versus three times daily in the treatment of acute otitis media in children. The Augmentin 454 Study Group. Journal of Chemotherapy 2000;12(1):78-97.
Hoberman 1997 {published data only}
  • Hoberman A, Paradise JL, Burch DJ, Valinski WA, Hedrick JA, Aronovitz GH, et al. Equivalent efficacy and reduced occurrence of diarrhea from a new formulation of amoxicillin/clavulanate potassium (Augmentin) for treatment of acute otitis media in children. Pediatric Infectious Diseases Journal 1997;16(5):463-70.
Murph 1993 {published data only}
Principi 1986 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Jacobsson 1993 {published data only}
  • Jacobsson S, Fogh A, Larsson A, Lomborg S. Evaluation of amoxicillin clavulanate twice daily versus thrice daily in the treatment of otitis media in children. Danish-Swedish Study Group. European Journal of Clinical Microbiology and Infectious Diseases 1993;12(5):319-24. [MEDLINE: 8354296]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
AAPS 2004
  • American Academy of Pediatrics Subcommittee. Diagnosis and management of acute otitis media. Pediatrics 2004;113:1451-65. [PUBMED: 15121972]
Barnett 1995
  • Barnett ED, Klein JO. The problem of resistant bacteria for the management of acute otitis media. Pediatric Clinics of North America 1995;42(3):509-17. [PUBMED: 7761138]
Carlin 1987
  • Carlin SA, Marchant CD, Shurin PA, Johnson CE, Murdell-Panek D, Barenkamp SJ. Early recurrences of otitis media: reinfection or relapse?. Journal of Pediatrics 1987;110(1):20-5. [PUBMED: 3540247]
Cars 1997
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Daly 1999
Drusano 1997
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Duval 2000
Faden 1994
  • Faden H, Doern G, Wolf J, Blocker M. Antimicrobial susceptibility of nasopharyngeal isolates of potential pathogens recovered from infants before antibiotic therapy: implications for the management of otitis media. Pediatric Infectious Diseases Journal 1994;13(7):609-12. [PUBMED: 7970948]
Froom 1997
  • Froom J, Culpepper L, Jacobs M, DeMelker RA, Green LA, van Buchem L, et al. Antimicrobials for acute otitis media? A review from the International Primary Care Network. BMJ 1997;315(7100):98-102. [PUBMED: 9240050]
Grob 1992
  • Grob PR. Antibiotic prescribing practices and patient compliance in the community. Scandinavian Journal of Infectious Diseases - Supplementum 1992;83:7-14. [PUBMED: 1488629]
Henderson 1988
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Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Jacobs 1998
  • Jacobs MR, Dagan R, Appelbaum PC, Burch DJ. Prevalence of antimicrobial-resistant pathogens in middle ear fluid: multinational study of 917 children with acute otitis media. Antimicrobial Agents and Chemotherapy 1998;42(3):589-95. [PUBMED: 9517937]
Johnson 1996
  • Johnson AP, Speller DC, George RC, Warner M, Domingue G, Efstratiou A. Prevalence of antibiotic resistance and serotypes in pneumococci in England and Wales: results of observational surveys in 1990 and 1995. BMJ 1996;312:1454-6. [PUBMED: 8664623]
Kaplan 1995
  • Kaplan SL. The emergence of resistant pneumococcus as a pathogen in childhood upper respiratory infections. Seminars in Respiratory Infections 1995;10:31-6. [PUBMED: 7761712 ]
Kardas 2007
  • Kardas P. Comparison of patient compliance with once-daily and twice-daily antibiotic regimens in respiratory tract infections: results of a randomized trial. Journal of Antimicrobial Chemotherapy 2007;59:531-6. [PUBMED: 17289766]
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville G. Chapter 6: Searching for studies. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. Available from www.cochrane-handbook.org. Chichester, UK: Wiley-Blackwell, 2011.
Leibovitz 2003
  • Leibovitz E. Acute otitis media in pediatric medicine: current issues in epidemiology, diagnosis, and management. Paediatric Drugs 2003;5(Suppl 1):1-12. [PUBMED: 14632101]
Light 1984
  • Light RJ, Pillemer DB. Summing Up: The Science of Reviewing Research. Cambridge, Massachusetts: Harvard University Press, 1984.
McCaig 1995
  • McCaig LF, Hughes JM. Trends in antimicrobial drug prescribing among of office-based physicians the United States. JAMA 1995;273:214-9. [PUBMED: 7807660]
Pechere 2007
  • Pechere JC, Hughes D, Kardas P, Cornaglia G. Non-compliance with antibiotic therapy for acute community infections: a global survey. International Journal of Antimicrobial Agents 2007;29:245-53. [PUBMED: 17229552]
Pichichero 2003
  • Pichichero ME, Casey JR. Acute otitis media disease management. Minerva Pediatrica 2003;55(5):415-38. [PUBMED: 14608265]
RevMan 2012
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Rosenfeld 2001
  • Rosenfeld RM, Casselbrant ML, Hannley MT. Implications of the AHRQ evidence report on acute otitis media. Otolaryngology - Head and Neck Surgery 2001;125(5):440-8. [PUBMED: 14608265]
Rovers 2004
Rovers 2006
  • Rovers MM, Glasziou P, Appelman CL, Burke P, McCormick DP, Damoiseaux RA, et al. Antibiotics for acute otitis media: a meta-analysis with individual patient data. Lancet 2006;368(9545):1429-35. [PUBMED: 17055944]
Teele 1989
  • Teele DW, Klein JO, Rosner B. Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. Journal of Infectious Diseases 1989;160(1):83-94. [PUBMED: 2732519]
Urquhart 1992
  • Urquhart J. Ascertaining how much compliance is enough with outpatient antibiotic regimens. Postgraduate Medical Journal 1992;68(Suppl 3):49-58. [PUBMED: 1287619]
Venekamp 2013

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Thanaviratananich 2008
Thanaviratananich 2011