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Aripiprazole alone or in combination for acute mania

  1. Rachel Brown1,*,
  2. Matthew J Taylor2,
  3. John Geddes3

Editorial Group: Cochrane Common Mental Disorders Group

Published Online: 17 DEC 2013

Assessed as up-to-date: 31 JUL 2013

DOI: 10.1002/14651858.CD005000.pub2


How to Cite

Brown R, Taylor MJ, Geddes J. Aripiprazole alone or in combination for acute mania. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD005000. DOI: 10.1002/14651858.CD005000.pub2.

Author Information

  1. 1

    Oxford Health NHS Foundation Trust, Clinical Pharmacy Support Unit, Oxford, UK

  2. 2

    Institute of Psychiatry, King's College London, Department of Psychosis Studies, London, UK

  3. 3

    University of Oxford/Warneford Hospital, Department of Psychiatry, Oxford, UK

*Rachel Brown, Clinical Pharmacy Support Unit, Oxford Health NHS Foundation Trust, Unit 46, Sandford Lane, Kennington, Oxford, OX1 5RW, UK. rachel.brown@oxfordhealth.nhs.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 17 DEC 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
CN138-007 {published and unpublished data}
  • Bristol-Myers Squibb. Clinical study report synopsis, protocol CN138-007 [data on file].
  • El Mallakh RS, Vieta E, Rollin L, Marcus R, Carson WH, McQuade R. A comparison of two fixed doses of aripiprazole with placebo in acutely relapsed, hospitalized patients with bipolar disorder I (manic or mixed) in subpopulations (CN138-007). European Neuropsychopharmacology 2010;11:776-83.
Findling 2009 {published and unpublished data}
  • Findling RL, Nyilas M, Forbes RA, McQuade RD, Jin N, Iwamoto T, et al. Acute treatment of pediatric bipolar I disorder, Manic or mixed episode, with aripiprazole:randomized, double-blind, placebo-controlled study [NCT00110461]. Journal of Clinical Psychiatry 2009;70(10):1441-51.
  • Findling RL, Youngstrom EA, Zhao J, Marcus R, Andersson C, McQuade R, et al. Respondent and item level patterns of response of aripiprazole in the acute treatment of pediatric bipolar i disorder. Journal of Affective Disorders 2012;143(1-3):231-5.
  • Loze J-Y, Forbes RA, Zhao J, Chen C-F, Carson W, Iwamoto T, et al. Line item analysis in child and adolescent patients with bipolar I disorder treated with Aripiprazole in an acute study (31-03-240) [conference abstract]. European Child and Adolescent Psychiatry [abstracts from the 14th International Congress of ESCAP European Society for Child and Adolescent Psychiatry] 2011;20:185.
  • Loze J-Y, Mankoski R, Zhao J, Carson W, Youngstrom E, Findling R, et al. Line item analysis in paediatric patients with bipolar I disorder treated with aripiprazole [conference abstract]. European Psychiatry [abstracts from the 19th European Congress of Psychiatry, EPA 2011 Mar 12-15; Vienna, Austria] 2011:26.
  • Mankoski R, Zhao J, Carson WH, Mathew SJ, Forbes RA. Young mania rating scale line item analysis in pediatric subjects with bipolar i disorder treated with aripiprazole in a short-term, double-blind, randomized study. Journal of Child and Adolescent Psychopharmacology 2011;21(4):359-64.
  • Mankoski R, Zhao J, Carson WH, Nyilas M, Mathew S, Forbes RA. YMRS line item analysis in pediatric patients with bipolar i disorder treated with aripiprazole [conference abstract]. 163rd Annual Meeting of the American Psychiatric Association; 2010 May 22-26; New Orleans, LA 2010:NR4-70.
  • Youngstrom E, Zhao J, Mankoski R, Forbes RA, Marcus RM, Carson W, McQuade R, et al. Clinical significance of treatment effects with aripiprazole versus placebo in a study of manic or mixed episodes associated with pediatric bipolar I disorder. Journal of Child and Adolescent Psychopharmacology 2013;23(2):72-9.
Keck 2003 {published data only}
  • Jody D, Marcus R, Keck P, Saha AR, Iwamoto T, Tourkodimitris S, et al. Aripiprazole vs placebo in acute mania [abstract]. International Journal of Neuropsychopharmacology [Proceedings of the 23rd Congress of the Collegium Internationale Neuro-Psychopharmacologicum; 2002 June 23-27; Montreal, Canada] 2002;5(Suppl 1):57.
  • Keck PE, Marcus R, Tourkodimitris S, Ali M, Liebeskind A, Saha A, et al. A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania. American Journal of Psychiatry 2003;160(9):1651-8.
  • Marcus R, Saha A, Jody D, Tourkodimitris S, Archibald D, Iwamoto T. Aripiprazole versus placebo in acute mania. New Research Abstracts, 155th Annual Meeting of the American Psychiatric Association; 2002 May 18-23; Philadelphia, Pennsylvania, USA.. San Francisco: American Psychiatric Association, 2002:p86, Abstract no: NR314.
  • Marcus R, Saha A, Jody D, Tourkodimitris S, Archibald D, Iwamoto T. Aripiprazole versus placebo in acute mania [abstract]. European Neuropsychopharmacology [Proceedings of the 15th International Congress of the European College of Neuropsychopharmacology; 2002 October 5-9; Barcelona, Spain] 2002;12(Suppl 3):S289.
Keck 2009 {published and unpublished data}
  • Bristol Myers-Squibb. Addendum to Clinical Study Report for Study CN138135: A multicenter, randomized, double-blind, placebo-controlled study of aripiprazole monotherapy in the treatment of acutely manic patients with bipolar I disorder. Clinical Trials Results Bristol-Myers Squibb [http://ctr.bms.com] 2008.
  • Bristol Myers-Squibb. Clinical study report synopsis: A multicenter, randomized, double-blind, placebo-controlled study of aripiprazole monotherapy in the treatment of acutely manic patients with bipolar I disorder [CN138135]. Clinical Trials Results Bristol-Myers Squibb [http://ctr.bms.com] 2008.
  • El-Mallakh RS, Marcus R, Baudelet C, McQuade R, Carson WH, Owen R. A 40-week double-blind aripiprazole versus lithium follow-up of a 12-week acute phase study (total 52 weeks) in bipolar i disorder. Journal of Affective Disorders 2012;136(3):258-66.
  • Keck PE, Orsulak PJ, Cutler AJ, Sanchez R, Torbeyns A, Marcus RN, et al. Aripiprazole monotherapy in the treatment of acute bipolar I mania: a randomised, double-blind, placebo and lithium controlled study. Journal of Affective Disorders 2009;112:36-49.
NCT00665366 {unpublished data only}
  • Bristol Myers Squibb. Study to evaluate the efficacy and safety of aripiprazole administered with lithium or valproate over 12 weeks in the treatment of mania in bipolar I disorder. http://clinicaltrials.gov/show/NCT00665366 2013.
Sachs 2006 {published and unpublished data}
  • Bristol-Myers Squibb. Clinical study report synopsis: a multicenter, randomized, double-blind study of aripiprazole versus placebo in the treatment of acutely manic patients with bipolar disorder [CN138074]. Clinical Trials Results Bristol-Myers Squibb [http://ctr.bms.com] 2003.
  • Hadjakis WJMarcus R, Abou-Gharbia N, Tourkodimitris S, Archibald DG, Carson WH, Iwamoto T, et al. Aripiprazole in acute mania: results from a second placebo-controlled study. Bipolar Disorders 2004;6(Suppl 1):39-40.
  • Sachs G, Sanchez R, Marcus R, Stock E, McQuade R, Carson W, et al. Aripiprazole in the treatment of acute manic or mixed episodes in patients with bipolar I disorder: a 3 week placebo-controlled study. Journal of Psychopharmacology 2006;20(4):536-46.
  • Sachs GS, Sanchez R, Marcus RN, Kujawa MJ, Archibald DG, Carson WH Jr, et al. Aripiprazole versus placebo in patients with an acute manic or mixed episode. New Research Abstracts, 157th Annual Meeting of the American Psychiatric Association; 2004 May 1-6; New York, NY. 2004:p279, Abstract No:NR742.
Tramontina 2009 {published and unpublished data}
  • Tramontina S, Zeni CP, Ketzer CR, Phuela GF, Narvaez J, Rohde LA. Aripiprazole in children and adolescents with bipolar disorder comorbid with attention-deficit/hyperactivity disorder:a pilot randomised clinical trial [NCT00116259]. Journal of Clinical Psychiatry 2009;70(5):756-64.
Vieta 2005 {published and unpublished data}
  • Bourin M, Auby P, Marcus RN, Swanik R, McQuade RD, Iwamoto T, et al. Aripiprazole versus haloperidol for maintained treatment effect in acute mania. New Research Abstracts 156th Annual Meeting of the American Psychiatric Association; 2003 May 17-22; San Francisco CA. 2003:p175, Abstract No:NR467.
  • Bourin M, Auby P, Swanik E, Marcus R, McQuade R, Iwamoto T, et al. Aripiprazole vs. haloperidol for maintained treatment effect in acute mania. European Neuropsychopharmacology [abstracts of the 16th Congress of the European College of Neuropsychopharmacology; 2003 September 20-24; Prague, Czech Republic] 2003;13(Suppl 4):S333.
  • Bristol Myers-Squibb. Clinical study report synopsis: a multicenter, randomized, double-blind study of aripiprazole and haloperidol in the maintained response to treatment for an acute manic episode (Protocol CN138008). Clinical Trials Results Bristol-Myers Squibb [http://ctr.bms.com] 2003.
  • Bristol-Myers Squibb. Cumulative 26-Week Clinical Study Report Including the 14-Week Extension Phase CN138008: a multicenter, randomized, double-blind study of aripiprazole and haloperidol in the maintained response to treatment for an acute manic episode. Clinical Trials Results Bristol-Myers Squibb [http://ctr.bms.com] 2003.
  • Sanchez R, Bourin M, Auby P, Swanik R, Marcus R, McQuade RD, et al. Aripiprazole vs. haloperidol for maintained treatment effect in acute mania. Bipolar Disorders [Posters - Fifth International Conference on Bipolar Disorder; 2003 June 12-14; Pittsburgh, PA, USA] 2003;5(Suppl1):p80, Abstract no:174.
  • Vieta E, Bourin M, Sanchez R, Marcus R, Stock E, McQuade R, et al. Effectiveness of aripiprazole v. haloperidol in acute bipolar mania: double-blind, randomised, comparative 12-week trial. British Journal of Psychiatry 2005;187:235-42.
Vieta 2008 {published and unpublished data}
  • Bristol-Myers Squibb. Addendum 01 to Clinical Study Report for Study CN138134: efficacy of aripiprazole in combination with valproate or lithium in the treatment of mania in patients with bipolar I disorder partially nonresponsive to valproate or lithium monotherapy. Clinical Trials Results Bristol-Myers Squibb [http://ctr.bms.com] 2008.
  • Bristol-Myers Squibb. Clinical study synopsis report: efficacy of aripiprazole in combination with valproate or lithium in the treatment of mania in patients with bipolar I disorder partially nonresponsive to valproate or lithium monotherapy [CN138134]. Clinical Trials Results Bristol-Myers Squibb [http://ctr.bms.com] 2007.
  • VIeta E, T'joen C, MacQuade RD, Carson WHJr, Marcus RN, Sanchez R, et al. Efficacy of adjunctive aripiprazole to either valproate or lithium in bipolar mania patients partially nonresponsive to valproate or lithium monotherapy: a placebo-controlled study [NCT00257972, CN138-134] [Comment in Am J Psychiatry. 2008 Oct;165(10):1234-6]. American Journal of Psychiatry 2008;165(10):1316-25.
Young 2009 {published and unpublished data}
  • Bristol-Myers Squibb. Clinical study synopsis report: a multicenter, randomized, double-blind, placebo-controlled study of aripiprazole monotherapy in the treatment of acutely manic patients with bipolar I disorder [CN138162]. Clinical Trials Results Bristol-Myers Squibb [http://ctr.bms.com] 2007.
  • Young AH, Oren DA, Lowy A, McQuade RD, Marcus RN, Carson WH, et al. Aripiprazole monotherapy in acute mania: 12 week randomised placebo- and haloperidol-controlled study [NCT00097266, CN138-162]. British Journal of Psychiatry 2009;194(1):40-8.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
CN138077 {unpublished data only}
  • Bristol Myers Squibb. Synpotic Clinical Study Report: a multicentre, randomized, double-blind, placebo-controlled study of aripiprazole in the treatment of acutely manic patients with bipolar disorder [CN138077]. Clinical Trials Results Bristol Myers Squibb [http://ctr.bms.com].
CN138189 {unpublished data only}
  • Abbar M, Khan A, Rollin L, Sanchez R, Carson W, Morris B, et al. Efficacy of adjunctive aripiprazole to lithium or valproate in the long-term treatment of mania in subjects with bipolar I disorder (CN138-189) [conference abstract]. European Psychiatry [abstracts from the 19th European Congress of Psychiatry, EPA 2011 Mar 12-15; Vienna, Austria] 2011;26(Suppl 1):186. [DOI: dx.doi.org/10.1016/S0924-9338(11)71897-1]
  • Ammerman D, Fyans P, Marler SV, Forbes RA, Rahman Z, Baker RA, et al. Aripiprazole with lithium or valproate in the long-term treatment of mania in patients with bipolar I disorder (CN138-189) [conference poster P3]. Bipolar Disorders [abstracts of the 9th International Conference on Bipolar Disorder; 9 - 11 June 2011, Pittsburgh, PA United States] 2011;13(s1):27.
  • Bristol Myers Squibb. Clinical study report synopsis: efficacy of aripiprazole in combination with lithium or valproate in the long term treatment of mania in patients with bipolar I disorder partially nonresponsive to lithium or valproate monotherapy [CN138189]. Clinical Trials Results Bristol Myers Squibb [http://ctr.bms.com].
  • De Hert M, Kemp DE, Fyans P, Rahman Z, Marler SV, Eudicone JM, et al. Long-term metabolic effects of aripiprazole adjunctive to lithium, valproate or lamotrigine [conference abstract]. European Neuropsychopharmacology [abstracts from the 24th Congress of the European College of Neuropsychopharmacology, ECNP 2011 Paris France, 3-7 Sept] 2011;21(Suppl 3):S431.
  • Fountoulakis KN, Ammerman D, Fyans P, Marler SV, Forbes RA, Rahman Z, et al. Effect of aripiprazole adjunctive to lithium or valproate on manic and mixed subpopulations: 52-week, double-blind, randomised relapse prevention trial [conference abstract]. European Neuropsychopharmacology [abstracts from the 24th Congress of the European College of Neuropsychopharmacology, ECNP 2011 Paris France, 3-7 Sept] 2011;21(Suppl 3):S429.
  • Marcus R, Khan A, Rollin L, Morris B, Timko K, Carson W, et al. Efficacy of aripiprazole adjunctive to lithium or valproate in the long-term treatment of patients with bipolar I disorder with an inadequate response to lithium or valproate monotherapy: a multicenter, double-blind, randomized study [CN138-189]. Bipolar Disorders 2011;13(2):133-44.
  • Masand PS, Tohen M, Everitt AL, Baker RA, Forbes RA, Carlson BX. Does shorter vs. longer time to stabilization in patients with bipolar i disorder predict relapse prevention? (CN138-189) [conference poster P132]. Bipolar Disorders [abstracts of the 9th International Conference on Bipolar Disorder; 9 - 11 June 2011, Pittsburgh, PA United States] 2011;13(s1):70.
  • Owen R, Rollin L, Khan A, Sanchez R, Carson W, Morris B, et al. Efficacy of adjunctive aripiprazole to lithium or valproate in the long-term treatment of mania in subjects with bipolar i disorder (CN138-189) [conference abstract].. 163rd Annual Meeting of the American Psychiatric Association; 2010 May 22-26; New Orleans, LA 2010:NR4-69.
  • Yatham LN, Fountoulakis KN, Rahman Z, Ammerman D, Fyans P, Marler SV, et al. Efficacy of aripiprazole versus placebo as adjuncts to lithium or valproate in relapse prevention of manic or mixed episodes in bipolar i patients stratified by index manic or mixed episode. Journal of Affective Disorders 2013;147(1-3):365-72.
NCT00484471 {unpublished data only}
  • Korea Otsuka International Asia Arab. A double-blind, randomized, placebo-controlled trial of aripiprazole plus valproate in the short-term and long-term treatment of bipolar disorder. http://clinicaltrials.gov/show/NCT00484471 2012.
NCT00606229 {unpublished data only}
  • OtsukaPharmaceutical Co, Ltd. A multicentre investigative study of the safety and efficacy of long-term administration of aripiprazole in combination with mood stabilizer for the treatment of patients with bipolar disorder experiencing a manic or mixed episode. http://clinicaltrials.gov/ct2/show/NCT00606229 2011.
NCT01567527 {unpublished data only}
  • Otsuka Pharmaceutical Development & Commercialization, Inc. Efficacy, safety, and tolerability of an intramuscular formulation of aripiprazole (OPC-14597) as maintenance treatment in bipolar I patients. http://clinicaltrials.gov/ct2/show/NCT01567527 (accessed 19 August 2013).
Woo 2011 {published and unpublished data}
  • Bhak WM, Woo YS, Chung MY, Kim DH, Yoon BH, Lee JH, et al. A randomised, double-blind, placebo-controlled 24 week trial of aripiprazole in recently remitted bipolar I patients [conference abstract, NCT00545675]. Neuropsychopharmacology [abstracts from the 24th Congress of the European College of Neuropsychopharmacology, ECNP 2011 Paris France, 3-7 Sept] 2011;21(Suppl 3):S482.
  • Korea Otsuka Pharmaceutical Co, Ltd. Multicentre, double-blind, randomized, comparative phase 4 clinical trial to evaluate the efficacy and safety of co-administration of Abilify and Depakote in 24 week treatment of mania in patients with bipolar disorder remitted after 6-week treatment with Abilify and Depakote. http://clinicaltrials.gov/ct2/show/NCT00545675 2010.
  • Woo YS, Bahk WM, Chung MY, Kim DH, Yoon BH, Lee JH, et al. Aripiprazole plus divalproex for recently manic or mixed patients with bipolar I disorder: a 6 month, randomized, placebo-controlled, double-blind maintenance trial. Human Psychopharmacology 2011;26(8):543-53. [DOI: 10.1002/hup.1240]
Zeni 2009 {published data only}
  • Zeni CP, Tramontina S, Ruffoni K, Pheula GF, Rohde LA. Methylphenidate combined with aripiprazole in children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder: a randomised crossover trial. Journal of Child and Adolescent Psychopharmacology 2009;19(5):553-61.
Zimbroff 2007 {published and unpublished data}
  • Bristol Myers Squibb. Clinical study report synopsis: a randomised, double-blind comparison of the efficacy and safety of aripiprazole intramuscular formula, lorazepam, or placebo in the treatment of acutely agitated patients diagnosed with bipolar I disorder, manic or mixed [CN138013]. Clinical Trials Results Bristol-Myers Squibb [http://ctr.bms.com].
  • Zimbroff DL, Marcus RN, Manos G, Stock E, McQuade RD, Auby P, et al. Management of acute agitation in patients with bipolar disorder - efficacy and safety of intramuscular aripiprazole. Journal of Clinical Psychopharmacology 2007;27(2):171-6.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Kanba 2012 {published and unpublished data}
  • Kanba S, Kawasaki H, Ishigooka J, Sakamoto K, Kinoshita T, Kuroki T. A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole for the treatment of acute manic or mixed episodes in Asian patients with bipolar I disorder (the AMAZE study). World Journal of Biological Psychiatry 2012;epub ahead of print. [DOI: 10.3109/15622975.2012.669047]
  • Kawasaki H, Kanba S, Kuroki T. A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole for the treatment of acute manic or mixed episodes in Asian patients with bipolar I disorder (The AMAZE Study) [poster P116]. Bipolar Disorders [abstracts of the 5th Biennial Conference of the International Society for Bipolar Disorders. March 14-17, 2012. Istanbul, Turkey] 2012;14(Suppl 1):88.
  • Otsuka Pharmaceutical Co, Ltd. A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group-Comparison Trial of Aripiprazole in the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episode. http://ClinicalTrials.gov/ct2/show/NCT00606281 (accessed 19 August 2013).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
APA 1994
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Health Disorders. 4th Edition. Washington, DC: APA, 1994.
APA 2002
  • American Psychiatric Association. Practice Guideline for the Treatment of Patients with Bipolar Disorder (Revision). American Journal of Psychiatry 2002;159(Suppl 4):4-51.
Argo 2004
BMS 2012
  • Bristol Myers Squibb. Clinical trial results. BMS.com (www.bms.com/clinical_trials/results/Pages/default.aspx) (accessed February 2012).
Carson 2002
  • Carson WH, Saha AR, Iwamoto T, Lin C, Kujawa MJ. Meta-analysis of prolactin effects with aripiprazole. International Journal of Neuropsychopharmacology 2002;5(1 Suppl):S186.
Cipriani 2006
Cipriani 2011
  • Cipriani A, Barbui C, Salanti G, Rendell J, Brown R, Stockton S, et al. Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet 2011;378:1306-15.
De Fazio 2010
  • De Fazio P, Girardi P, Maina G, Mauri MC, Mauri M, Monteleone P, et al. Aripiprazole in acute mania and long-term treatment of bipolar disorder. Clinical Drug Investigation 2010;30(12):827-41.
de Zelicourt 2003
  • de Zelicourt M, Dardennes R, Verdoux H, Gandhi G, Khoshnood B, Chomette E. Frequency of hospitalisations and inpatient care costs of manic episodes in patients with bipolar I disorder in France. Pharmacoeconomics 2003;12(15):1081-90.
Dunner 2000
  • Dunner DL. Optimizing lithium treatment. Journal of Clinical Psychiatry 2000;61(Suppl 9):76-81.
ElMallakh 2010
  • ElMallakh RS, Vieta E, Rollin L, Marcus R, Carson WH, McQuade R. A comparison of two fixed doses of aripiprazole with placebo in acutely relapsed, hospitalized patients with bipolar disorder I (manic or mixed) in subpopulations (CN138-007). European Neuropsychopharmacology 2010;11:776-83.
EMEA 2001
  • The European Agency for the Evaluation of Medicinal Products. Note for guidance on clinical investigation of medicinal products for the treatment and prevention of bipolar disorder. http://www.emea.eu.int/pdfs/human/ewp/056798en.pdf (accessed 19 April 2004).
Fountoulakis 2009
  • Fountoulakis KN, Vieta E. Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review. Annals of General Psychiatry 2009;8:16.
Fountoulakis 2011
Geddes 2000
Goodwin 2009
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Grunder 2003
Higgins 2011
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Jody 2002
  • Jody D, Saha AR, Iwamoto T, Biswas D, Lin C, Marcus R, et al. Meta-analysis of weight effects with aripiprazole. International Journal of Neuropsychopharmacology 2002;5(1 Suppl):S186.
Jordan 2002
  • Jordan S, Koprivica V, Chen R, Tottori K, Kikuchi T, Altar CA. The antipsychotic aripiprazole is a potent, partial agonist at human 5HT1a receptor. European Journal of Pharmacology 2002;441(3):137-40.
Keck 2002
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Manji 2000
Marder 2003
  • Marder SR, McQuade RD, Stock E, Kaplita S, Marcus R, Safferman AZ, et al. Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term, placebo-controlled trials. Schizophrenia Research 2003;61(2-3):123-36.
Nivoli 2012
Olie 2002
Perucca 2002
Rendell 2003
  • Rendell JM, Gijsman HJ, Keck PK, Goodwin G, Geddes J. Olanzapine alone or in combination for acute mania. Cochrane Database of Systematic Reviews 2003, Issue Issue 1. [DOI: 10.1002/14651858.CD004040]
Rendell 2006
Segal 2000
Smith 2007
Stock 2002
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Streiner 2008
  • Streiner DL. Missing data and the trouble with LOCF. Evidence Based Mental Health 2008;11(1):3-5.
Taylor 2003
Waraich 2004
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WHO 1992
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Yatham 2002
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