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Enteral iron supplementation in preterm and low birth weight infants

  1. Ryan John Mills1,*,
  2. Mark W Davies2

Editorial Group: Cochrane Neonatal Group

Published Online: 14 MAR 2012

Assessed as up-to-date: 12 AUG 2011

DOI: 10.1002/14651858.CD005095.pub2


How to Cite

Mills RJ, Davies MW. Enteral iron supplementation in preterm and low birth weight infants. Cochrane Database of Systematic Reviews 2012, Issue 3. Art. No.: CD005095. DOI: 10.1002/14651858.CD005095.pub2.

Author Information

  1. 1

    Logan Hospital and University of Queensland, Department of Paediatrics, Loganholme DC, Queensland, Australia

  2. 2

    Department of Paediatrics & Child Health, The University of Queensland, Grantley Stable Neonatal Unit, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia

*Ryan John Mills, Department of Paediatrics, Logan Hospital and University of Queensland, P.O. Box 4096, Loganholme DC, Queensland, 4129, Australia. Ryan_Mills@health.qld.gov.au.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 14 MAR 2012

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Aggarwal 2005 {published data only}
  • Aggarwal D, Sachdev HP, Nagpal J, Singh T, Mallika V. Haematological effect of iron supplementation in breast fed term low birth weight infants. Archives of Disease in Childhood 2005;90:26-9.
Arnon 2009 {published data only}
  • Arnon S, Regev RH, Bauer S, Shainkin-Kestenbaum R, Shiff Y, Bental Y, et al. Vitamin E levels during early iron supplementation in preterm infants. American Journal of Perinatology 2009;26:387-92.
Barclay 1991 {published data only}
Berglund 2010 {published data only}
Berseth 2004 {published data only}
Coles 1954 {published data only}
Diamond 1958 {published data only}
  • Diamond EF, Gonzales FG, Pisani A. The effect of cobalt-iron therapy on the blood picture in premature infants. Illinois Medical Journal 1958;113:154-6.
Ferlin 1998 {published data only}
Franz 2000 {published data only}
  • Franz AR, Mihatsch WA, Sander S, Kron M, Pohlandt F. Prospective randomized trial of early versus late enteral iron supplementation in infants with a birth weight of less than 1301 grams. Pediatrics 2000;106:700-6.
Friel 2001 {published data only}
  • Andrews WL, Friel JK, Simmons B, Aziz K, Kwa PG, Downton G. Effect of two levels of iron supplementation of infant formulas on developmental outcome and iron nutrition in very low birth weight infants. Pediatric Research 1998;43:255A.
  • Friel JK, Andrews WL, Aziz K, Kwa PG, Lepage G, L'Abbe MR. A randomized trial of two levels of iron supplementation and developmental outcome in low birth weight infants. Journal of Pediatrics 2001;139:254-60.
Gorten 1964 {published data only}
Griffin 1999 {published data only}
  • Griffin IJ, Cooke RJ, Reid MM, McCormick KP, Smith JS. Iron nutritional status in preterm infants fed formulas fortified with iron. Archives of Disease in Childhood Fetal and Neonatal Edition 1999;81:45-9.
Groh-Wargo 1990 {published data only}
  • Groh-Wargo SL, Danish EH, Super DM. Iron therapy in the premature infant. Pediatric Research 1990;27:284A.
Gross 1985 {published data only}
Hall 1993 {published data only}
  • Hall RT, Wheeler RE, Benson J, Harris G, Rippetoe L. Feeding iron-fortified premature formula during initial hospitalization to infants less than 1800 grams birth weight. Pediatrics 1993;92:409-14.
Halliday 1983 {published data only}
Hanninen 1961 {published data only}
  • Hanninen P, Peltonen T, Salmi T. On the use of iron in the treatment of premature infants. Kinderarztliche Praxis 1961;29:521-4.
Jansson 1979 {published data only}
Lundstrom 1977 {published data only}
Melhorn 1971 {published data only}
Melnick 1988 {published data only}
  • Melnick G, Crouch JB, Caksackkas HL, Churella HR. Iron status of low-birth-weight infants fed formulas containing high or low iron content. Pediatric Research 1988;23:488A.
Quilligan 1954 {published data only}
  • Quilligan JJ Jr. Effect of a cobalt-iron mixture on the anemia of prematurity. Texas State Journal of Medicine 1954;50:294-6.
Reedy 1952 {published data only}
Rudolph 1981 {published data only}
Sankar 2009 {published data only}
Steinmacher 2007 {published data only}
  • Steinmacher J, Pohlandt F, Bode H, Sander S, Kron M, Franz AR. Randomized trial of early versus late enteral iron supplementation in infants with a birth weight of less than 1301 grams: neurocognitive development at 5.3 years' corrected age. Pediatrics 2007;120:538-46.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Arnon 2007 {published data only}
  • Arnon S, Shiff Y, Litmanovitz I, Regev RH, Bauer S, Shainkin-Kestenbaum R, et al. The efficacy and safety of early supplementation of iron polymaltose complex in preterm infants. American Journal of Perinatology 2007;24:95-100.
Brozovic 1974 {published data only}
Carnielli 1998 {published data only}
  • Carnielli VP, Da Riol R, Montini G. Iron supplementation enhances response to high doses of recombinant human erythropoietin in preterm infants. Archives of Disease in Childhood Fetal and Neonatal Edition 1998;79:F44-8.
Creutz 1958 {published data only}
  • Creutz E, Steinhoff A. Prevention of anemia in the newborn with cobalt-ferrlecit. Kinderarztliche Praxis 1958;26:17-20.
Del Mundo 1964 {published data only}
  • Del Mundo F, Adiao AC, Sta. Ana P. A study of iron depletion prophylaxis by the use of iron-containing milk formulas. Journal of the Philippine Medical Association 1964;40:779-86.
Dewey 2004 {published data only}
  • Dewey KG, Cohen RJ, Brown KH. Exclusive breast-feeding for 6 months, with iron supplementation, maintains adequate micronutrient status among term, low-birthweight, breast-fed infants in Honduras. Journal of Nutrition 2004;134:1091-8.
Friel 1995 {published data only}
  • Friel JK, Andrews WL, Hall MS, Rodway MS, McCloy UC, Matthew JD, et al. Intravenous iron administration to very-low-birth-weight newborns receiving total and partial parenteral nutrition. Journal of Parenteral and Enteral Nutrition 1995;19:114-8.
Friel 2003 {published data only}
  • Friel JK, Aziz K, Andrews WL, Harding SV, Courage ML, Adams RJ. A double-masked, randomized control trial of iron supplementation in early infancy in healthy term breast-fed infants. Journal of Pediatrics 2003;143:582-6.
Fydryk 1962 {published data only}
  • Fydryk J, Lacki L, Cieslak E. Treatment of hypochromic anemia in underweight infants with oral iron preparations. Pediatria Polska 1962;37:919-26.
Garry 1981 {published data only}
Graeber 1977 {published data only}
Greer 1988 {published data only}
  • Greer FR, McCormick A. Growth and calcium metabolism in premature infants fed varying amounts of protein and minerals during the first year of life. Pediatric Research 1988;23:492A.
Gross 1974 {published data only}
Heese 1990 {published data only}
  • Heese HD, Smith S, Watermeyer S, Dempster WS, Jakubiec L. Prevention of iron deficiency in preterm neonates during infancy. South African Medical Journal 1990;77:339-45.
James 1960 {published data only}
  • James JA, Combes M. Iron deficiency in the premature infant: Significance, and prevention by the intramuscular administration of iron-dextran. Pediatrics 1960;26:368-74.
Jobert 1975 {published data only}
  • Jobert J, Bachelot C, Jerome JM, Sele M, Bost M. Trial treatment of early anemia in premature infants. Pediatrie 1975;30:809-20.
Kivivuori 1999 {published data only}
  • Kivivuori SM, Virtanen M, Raivio KO, Viinikka L, Siimes MA. Oral iron is sufficient for erythropoietin treatment of very low birth-weight infants. European Journal of Pediatrics 1999;158:147-51.
Lindberg 1973 {published data only}
  • Lindberg T. Supply of vitamins and iron to premature babies. Lakartidningen 1973;70:3260-2.
Meyer 1996 {published data only}
  • Meyer MP, Haworth C, Meyer JH, Commerford A. A comparison of oral and intravenous iron supplementation in preterm infants receiving recombinant erythropoietin. Journal of Pediatrics 1996;129:258-63.
Miller 2006 {published data only}
Naude 2000 {published data only}
  • Naude S, Clijsen S, Naulaers G, Daniels H, Vanhole C, Devlieger H. Iron supplementation in preterm infants: a study comparing the effect and tolerance of a Fe2+ and a nonionic FeIII compound. Journal of Clinical Pharmacology 2000;40:1447-51.
Nazir 2002 {published data only}
  • Nazir S, Peverini RL, Derning DD, Hopper AO, Vyhmeister NR. Comparison of 2 iron doses in infants receiving recombinant human erythropoietin therapy. Archives of Pediatrics and Adolescent Medicine 2002;156:540-4.
Nelson 1988 {published data only}
Niccum 1953 {published data only}
  • Niccum WL, Jackson RL, Stearns G. Use of ferric and ferrous iron in the prevention of hypochromic anemia in infants. American Journal of Diseases in Children 1953;86:553-67.
Olivares 1992 {published data only}
Oski 1972 {published data only}
Owen 1981 {published data only}
Picciano 1980 {published data only}
Rothe-Meyer 1953 {published data only}
  • Rothe-Meyer A, Kreutzfeldt H. Iron therapy for the premature infant. Ugeskrift for Laeger 1953;115:331-3.
Saarinen 1978 {published data only}
Siep 1956 {published data only}
  • Halvorsen S, Seip M. Erythrocyte production and iron stores in premature infants during the first months of life; the anemia of prematurity-etiology, pathogenesis, iron requirement. Acta Paediatrica 1956;45:600-17.
Singhal 2000 {published data only}
Sitarz 1960 {published data only}
  • Sitarz AL, Wolff JA, Von Hofe FH. Comparison of oral and intramuscular administration of iron for prevention of the late anemia of premature infants. Pediatrics 1960;26:375-86.
Tevetoglu 1958 {published data only}
  • Tevetoglu F, Ozkaragoz K. Cobalt-iron therapy in the treatment and prevention of the anemia of prematurity. Medical Times 1958;86:81-7.
Tuttle 1952 {published data only}
Victorin 1984 {published data only}

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Hurgoiu 1986 {published data only}
  • Hurgoiu V, Rub-Saidac A, Filipas V, Marcu A, Adam M. Test of maternal milk supplemented with iron in the feeding of premature infants. Revista de Pediatrie, Obstetrica Si Ginecologie Pediatria 1986;35:91-5.
Neimann 1957 {published data only}
  • Neimann N, De Vezeaux De Lavergne E, Pierson M, Stehlin S, Daubinet G. Iron metabolism in infants and the problem of physiological hypochromic anemia in infancy, results of iron therapy. Semaine des Hopitaux 1957;33:4007-18P.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
AAP 1985
  • American Academy of Pediatrics Committee on Nutrition. Nutritional needs of low-birth-weight infants. Pediatrics 1985;75:976-86.
Baker 2010
  • Baker RD, Greer FR, Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics 2010;126:1040-50.
Brown 1996
  • Brown MS. Effect of transfusion and phlebotomy on serum ferritin levels in low birth weight infants. Journal of Perinatology 1996;16:39-42.
Cooke 1997
Dani 2001
Doyle 1992
  • Doyle JJ, Zipursky A. Neonatal blood disorders. In: Sinclair JC, Bracken MB editor(s). Effective Care of the Newborn Infant. Oxford: Oxford University Press, 1992:425.
Hesse 1997
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hyams 1995
  • Hyams JS, Treem WR, Etienne NL, Weinerman H, MacGilpin D, Hine P, et al. Effect of infant formula on stool characteristics of young infants. Pediatrics 1995;95:50-4.
Inder 1997
  • Inder TE, Clemett RS, Austin NC, Graham P, Darlow BA. High iron status in very low birth weight infants is associated with an increased risk of retinopathy of prematurity. Journal of Pediatrics 1997;131:541-4.
Lozoff 1987
  • Lozoff B, Brittenham GM, Wolf AW, McClish DK, Kuhnert PM, Jimenez E, et al. Iron deficiency anaemia and iron therapy effects on infant developmental test performance. Pediatrics 1987;79:981-95.
McGuire 2003
  • McGuire W, Anthony MY. Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review. Archives of Disease in Childhood Fetal & Neonatal Edition 2003;88:F11-4.
Ng 2001
  • Ng PC, Lam CW, Lee CH, To KF, Fok TF, Chan IH, et al. Hepatic iron storage in very low birthweight infants after multiple blood transfusions. Archives of Disease in Childhood Fetal & Neonatal Edition 2001;84:F101-5.
Rao 2002
RevMan 2011
  • Copenhagen: The Nordic Cochrane Centre. Review Manager (RevMan). Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011, Version 5.1.
Shaw 1982
  • Shaw JC. Iron absorption by the premature infant. The effect of transfusion and iron supplements on the serum ferritin levels. Acta Paediatrica Scandinavica Suppl 1982;299:83-9.
Walter 1989