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Intervention Protocol

Antiglucocorticoid treatments in mood disorders: efficacy and safety

  1. P Mackin,
  2. P Gallagher,
  3. K Froom,
  4. J Geddes,
  5. AH Young

Editorial Group: Cochrane Depression, Anxiety and Neurosis Group

Published Online: 24 JAN 2005

DOI: 10.1002/14651858.CD005168


How to Cite

Mackin P, Gallagher P, Froom K, Geddes J, Young AH. Antiglucocorticoid treatments in mood disorders: efficacy and safety (Protocol). Cochrane Database of Systematic Reviews 2005, Issue 1. Art. No.: CD005168. DOI: 10.1002/14651858.CD005168.

Author Information

*Dr Paul Mackin, Academic Specialist Registrar, Department of Psychiatry, University of Newcastle upon Tyne, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK. paul.mackin@ncl.ac.uk.

Publication History

  1. Published Online: 24 JAN 2005

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

1. To determine the efficacy of antiglucocorticoid drugs:
1.1 in improving mood symptoms in unipolar depression and bipolar disorder
1.2 in improving neuropsychological function in mood disorders
1.3 on patients' general health and social functioning as measured by clinical global impression

2. To assess the acceptibility of short-term treatment with antiglucocorticoid drugs to patients, measured by reference to patients' expressed views regarding treatment and patient satisfaction

3. To investigate the adverse effects of antiglucocorticoid drug treatment, including the general prevalence of side effects. The prevalence of the following adverse effects will be investigated:
Switch to depression
Switch to mania
Switch to a mixed affective state
Malaise
Lethargy
Dizziness
Confusion
Headache
Hypotension
Abdominal pain
Nausea and vomiting
Liver dysfunction
Rashes
Angioedema
Thrombocytopenia
Parasthesia
Photophobia
Alopecia
Hirsutism
Gynaecomastia
Death