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Interferon beta for secondary progressive multiple sclerosis

  • Protocol
  • Intervention


  • G PA Rice,

  • GC Ebers,

  • S Fredrikson,

  • D Mason,

  • F Tesser,

  • G Filippini

Prof George PA Rice, Clinical Neurological Sciences, University of Western Ontario, 339 Windermere Road, London, Ontario, N6A 5A5, CANADA.


This is the protocol for a review and there is no abstract. The objectives are as follows:

The primary question is whether interferon beta is more effective than placebo in decreasing the number of SPMS patients who experience disability progression during follow-up. We also aim to evaluate the incidence and seriousness of side effects and adverse events.

The secondary objectives are to examine the effect of interferon beta on relapses during follow-up, on patient activities of daily living and quality of life, and reducing the need for other treatments. We will also evaluate change in MRI parameters during follow-up.