Intervention Review

Normobaric and hyperbaric oxygen therapy for the treatment and prevention of migraine and cluster headache

  1. Michael H Bennett1,*,
  2. Christopher French2,
  3. Alexander Schnabel3,
  4. Jason Wasiak4,
  5. Peter Kranke3,
  6. Stephanie Weibel3

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 28 DEC 2015

Assessed as up-to-date: 15 JUN 2015

DOI: 10.1002/14651858.CD005219.pub3

How to Cite

Bennett MH, French C, Schnabel A, Wasiak J, Kranke P, Weibel S. Normobaric and hyperbaric oxygen therapy for the treatment and prevention of migraine and cluster headache. Cochrane Database of Systematic Reviews 2015, Issue 12. Art. No.: CD005219. DOI: 10.1002/14651858.CD005219.pub3.

Author Information

  1. 1

    Prince of Wales Clinical School, University of NSW, Department of Anaesthesia, Sydney, NSW, Australia

  2. 2

    University of Melbourne, Department of Medicine (RMH), Melbourne, Victoria, Australia

  3. 3

    University of Würzburg, Department of Anaesthesia and Critical Care, Würzburg, Germany

  4. 4

    The Epworth Hospital, Department of Radiation Oncology, Richmond, Australia

*Michael H Bennett, Department of Anaesthesia, Prince of Wales Clinical School, University of NSW, Sydney, NSW, Australia.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 28 DEC 2015




  1. Top of page
  2. Abstract
  3. Plain language summary
  4. Laički sažetak
  5. Резюме на простом языке


Migraine and cluster headaches are severe and disabling. Migraine affects up to 18% of women, while cluster headaches are much less common (0.2% of the population). A number of acute and prophylactic therapies are available. Hyperbaric oxygen therapy (HBOT) is the therapeutic administration of 100% oxygen at environmental pressures greater than one atmosphere, while normobaric oxygen therapy (NBOT) is oxygen administered at one atmosphere. This is an updated version of the original Cochrane review published in Issue 3, 2008 under the title 'Normobaric and hyperbaric oxygen for migraine and cluster headache'.


To examine the efficacy and safety of normobaric oxygen therapy (NBOT) and hyperbaric oxygen therapy (HBOT) in the treatment and prevention of migraine and cluster headache.

Search methods

We updated searches of the following databases up to 15 June 2015: CENTRAL (the Cochrane Library), MEDLINE, EMBASE, and CINAHL. For the original review we searched the following databases up to May 2008: CENTRAL, MEDLINE, EMBASE, CINAHL, DORCTIHM, and reference lists from relevant articles. We handsearched relevant journals and contacted researchers to identify trials.

Selection criteria

Randomised controlled trials comparing HBOT or NBOT with one another, other active therapies, placebo (sham) interventions, or no treatment in participants with migraine or cluster headache.

Data collection and analysis

Three review authors independently extracted data and assessed the quality of the evidence using the GRADE approach.

Main results

In this update, we included 11 trials with 209 participants. Five trials (103 participants) compared HBOT versus sham therapy for acute migraine, three trials compared NBOT to sham therapy or ergotamine tartrate for cluster headache (145 participants), two trials evaluated HBOT for cluster headache (29 participants), and one trial (56 participants) compared NBOT to sham for a mixed group of headache. The risk of bias varied considerably across these trials but in general trial quality was poor to moderate. One trial may not have been truly randomised and two included studies were reported as abstracts only. Seven trials did not indicate allocation concealment or randomisation method. Notably, 10 of the 11 trials used a sham comparator therapy and masked the outcome assessor to allocation.

We pooled data from three trials, which suggested that HBOT was effective in relieving migraine headaches compared to sham therapy (risk ratio (RR) 6.21, 95% CI 2.41 to 16.00; 58 participants, three trials). The quality of evidence was low, having been downgraded for small crossover studies with incomplete reporting. There was no evidence that HBOT could prevent migraine episodes, reduce the incidence of nausea and vomiting, or reduce the requirement for rescue medication. There was no evidence that HBOT was effective for the termination of cluster headache (RR 11.38, 95% CI 0.77 to 167.85; P = 0.08) (one trial), but this trial had low power.

NBOT was effective in terminating cluster headache compared to sham in a single small study (RR 7.88, 95% CI 1.13 to 54.66), but not superior to ergotamine administration in another small trial (RR 1.17, 95% CI 0.94 to 1.46; P = 0.16). A third trial reported a statistically significant difference in the proportion of attacks successfully treated with oxygen (117 of 150 attacks were successfully treated with NBOT (78%) versus 30 of 148 attacks treated with NBOT (20%)). The proportion of responders was consistent across these three trials, and suggested more than 75% of headaches were likely to respond to NBOT.

No serious adverse events during HBOT or NBOT were reported.

Authors' conclusions

Since the last version of this review, two new included studies have provided additional information to change the conclusions. There was some evidence that HBOT was effective for the termination of acute migraine in an unselected population, and some evidence that NBOT was similarly effective in cluster headache. Given the cost and poor availability of HBOT, more research should be done on patients unresponsive to standard therapy. NBOT is cheap, safe, and easy to apply, so will probably continue to be used despite the limited evidence in this review.


Plain language summary

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. Laički sažetak
  5. Резюме на простом языке

Normal pressure oxygen therapy and hyperbaric oxygen therapy for migraine and cluster headaches


Migraine and cluster headaches are severe and disabling. Hyperbaric oxygen therapy (HBOT, that is the breathing of pure oxygen at pressures greater than one atmosphere in a pressurised chamber) and normal pressure oxygen therapy (NBOT) can be delivered via a mask at home or in a clinic. These treatments may help to end acute attacks and prevent future attacks.


We originally searched the literature widely in May 2008, and most recently in June 2015. We looked for high quality trials that would help define whether or not there was good evidence for or against the use of oxygen for migraine or cluster headache. We included 11 trials in this review.

Quality of the evidence

We found some low quality evidence to suggest that HBOT relieves pain with acute migraine headaches and possibly cluster headaches, and that NBOT may relieve pain with cluster headache. We found no evidence that either treatment can prevent future attacks. Many migraines can be treated simply with appropriate drug therapy, so further research is needed to help choose the most appropriate patients (if any) to receive HBOT.


Laički sažetak

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. Laički sažetak
  5. Резюме на простом языке

Terapija kisikom pod normalnim tlakom i hiperbarična terapija kisikom za migrenu i glavobolje u nakupinama (cluster glavobolje)

Dosadašnje spoznaje

Migrena i glavobolje u nakupinama (engl. cluster) su teška i onesposobljavajuća stanja. Hiperbarična terapija kisikom (HBOT) uključuje udisanje čistog kisika pod tlakom većim od jedne atmosfere u komori koja je pod tlakom), a terapija kisikom pod normalnim tlakom (NBOT) može se davati kod kuće preko maske ili na klinici. Te terapije mogle bi možda pomoći u ublažavanju akutnih napadaja glavobolje i sprječavanju budućih napadaja.


U prvoj verziji sustavnog pregleda literatura je bila pretražena do svibnja 2008., a u ovoj obnovljenoj verziji pretražena je literatura objavljena do lipnja 2015. Tražene su visokokvalitetne studije koje bi mogle pomoći definirati postoje li dobri dokazi za ili protiv uporabe terapije kisikom u liječenju migrene ili glavobolje u nakupinama (tzv. cluster glavobolja). U ovaj Cochrane sustavni pregled literature uključeno je 11 studija.

Kvaliteta dokaza

U ovom Cochrane sustavnom pregledu autori su pronašli određene slabe dokaze koji sugeriraju da HBOT pomaže osobama s akutnim migrenskim glavoboljama i možda pomaže osobama s glavoboljama u nakupinama, te da NBOT može pomoći osobama s glavoboljama u nakupinama. Nisu nađeni dokazi da bilo koja od ovih terapija može spriječiti buduće napade. Budući da se mnoge migrene mogu jednostavno liječiti odgovarajućom terapijom lijekovima, potrebna su daljnja istraživanja kako bi se mogli odabrati najprikladniji bolesnici (ako ih ima) za primjenu HBOT-a.

Bilješke prijevoda

Hrvatski Cochrane
Prevele: Katarina Vučić i Livia Puljak
Ovaj sažetak preveden je u okviru volonterskog projekta prevođenja Cochrane sažetaka. Uključite se u projekt i pomozite nam u prevođenju brojnih preostalih Cochrane sažetaka koji su još uvijek dostupni samo na engleskom jeziku. Kontakt:


Резюме на простом языке

  1. Top of page
  2. Abstract
  3. Plain language summary
  4. Laički sažetak
  5. Резюме на простом языке

Терапия кислородом под нормальным давлением (НБО) и гипербарическая кислородная терапия (ГБО) при мигрени и кластерных головных болях


Мигрень и кластерные головные боли (приступообразные боли в части головы) тяжело переносятся и лишают возможности выполнять обычные действия. Гипербарическая кислородная терапия (ГБО - то есть вдыхание чистого кислорода под давлением более одной атмосферы в герметичной камере) и нормобарическая кислородная терапия (НБО - вдыхание кислорода при нормальном давлении) могут быть осуществлены с помощью маски в домашних условиях или в клинике. Такое лечение может способствовать купированию острого приступа (снятие боли) и предотвращению последующих мигренозных атак.


Мы первоначально провели обширный поиск литературы в мае 2008 года, и обновили его в июне 2015 года. Мы искали клинические испытания высокого качества, которые помогли бы определить, имеются ли достаточные основания (доказательства) за или против использования кислорода при мигрени или кластерной головной боли. Мы включили 11 испытаний в этот обзор.

Качество доказательств

Мы нашли доказательства низкого качества, что ГБО снимает боль при острых мигренозных головных болях и, возможно, при кластерных головных болях, и что НБО может облегчить кластерную головную боль. Мы не нашли доказательств, что кислородная терапия (либо ГБО, либо НБО) может предотвратить последующие атаки. Многие виды мигрени можно лечить просто с помощью соответствующих лекарств, поэтому необходимы дальнейшие исследования, чтобы помочь выделить наиболее подходящих пациентов (если таковые имеются) для лечения с помощью ГБО.

Заметки по переводу

Перевод: Зиганшина Лилия Евгеньевна. Редактирование: Юдина Екатерина Викторовна. Координация проекта по переводу на русский язык: Cochrane Russia - Кокрейн Россия (филиал Северного Кокрейновского Центра на базе Казанского федерального университета). По вопросам, связанным с этим переводом, пожалуйста, обращайтесь к нам по адресу: