Intervention Review

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Drug therapy for pain in amyotrophic lateral sclerosis or motor neuron disease

  1. Johannes Brettschneider1,*,
  2. Jerome Kurent2,
  3. Albert Ludolph1

Editorial Group: Cochrane Neuromuscular Group

Published Online: 5 JUN 2013

Assessed as up-to-date: 3 JUL 2012

DOI: 10.1002/14651858.CD005226.pub3


How to Cite

Brettschneider J, Kurent J, Ludolph A. Drug therapy for pain in amyotrophic lateral sclerosis or motor neuron disease. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD005226. DOI: 10.1002/14651858.CD005226.pub3.

Author Information

  1. 1

    University of Ulm, Neurology, Ulm, Germany

  2. 2

    Medical University of South Carolina, Department of Neurosciences, Charleston, South Carolina, USA

*Johannes Brettschneider, Neurology, University of Ulm, Oberer Eselsberg 45, Ulm, 89081, Germany. johannes.brettschneider@uni-ulm.de.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 5 JUN 2013

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References

References to studies excluded from this review

  1. References to studies excluded from this review
  2. Additional references
  3. References to other published versions of this review
Abe 2008 {published data only}
  • Abe Y, Miyashita M, Ito N, Shirai Y, Momose Y, Ichikawa Y, et al. Attitude of outpatients with neuromuscular diseases in Japan to pain and use of analgesics. Journal of the Neurological Sciences 2008;267(1-2):22-7. [PUBMED: 17916366]
Adelman 2004 {published data only}
  • Adelman EE, Albert SM, Rabkin JG, Del Bene ML, Tider T, O'Sullivan I. Disparities in perceptions of distress and burden in ALS patients and family caregivers. Neurology 2004;62(10):1766-70. [PUBMED: 15159475]
Amtmann 2004 {published data only}
  • Amtmann D, Weydt P, Johnson KL, Jensen MP, Carter GT. Survey of cannabis use in patients with amyotrophic lateral sclerosis. American Journal of Hospice and Palliative Care 2004;21(2):95-104. [PUBMED: 15055508]
Bedlack 2009 {published data only}
  • Bedlack RS, Pastula DM, Hawes J, Heydt D. Open-label pilot trial of levetiracetam for cramps and spasticity in patients with motor neuron disease. Amyotrophic Lateral Sclerosis 2009;10(4):210-5. [PUBMED: 18821142]
Borasio 2001a {published data only}
  • Borasio GD, Shaw PJ, Hardiman O, Ludolph AC, Sales Luis ML, Silani V, European ALS Study Group. Standards of palliative care for patients with amyotrophic lateral sclerosis: results of a European survey. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2001;2(3):159-64. [PUBMED: 11771773]
Bradley 2001 {published data only}
  • Bradley WG, Anderson F, Bromberg M, Gutmann L, Harati Y, Ross M, et al. ALS CARE Study Group. Current management of ALS: comparison of the ALS CARE Database and the AAN Practice Parameter. The American Academy of Neurology. Neurology 2001;57(3):500-4. [PUBMED: 11502920]
Carter 2010 {published data only}
  • Carter GT, Abood ME, Aggarwal SK, Weiss MD. Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials. The American Journal of Hospice and Palliative Care 2010;27(5):347-56. [PUBMED: 20439484]
Chio 2001 {published data only}
  • Chiò A, Silani V, Italian ALS Study Group. Amyotrophic lateral sclerosis care in Italy: a nationwide study in neurological centers. Journal of the Neurological Sciences 2001;191(1-2):145-50. [PUBMED: 11677006]
de Carvalho 2001 {published data only}
  • de Carvalho M. Gabapentin for the treatment of spasticity in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2001;2(1):47-8. [PUBMED: 11465933]
de Castro-Costa 1999 {published data only}
  • de Castro-Costa CM, Oria RB, Machado-Filho JA, Franco MT, Diniz DL, Giffoni SD, et al. Amyotrophic lateral sclerosis. Clinical analysis of 78 cases from Fortaleza (northeastern Brazil). Arquivos de Neuro-Psiquiatria 1999;57(3B):761-74. [PUBMED: 10751910]
Drake 1983 {published data only}
Forshew 2003 {published data only}
  • Forshew DA, Bromberg MB. A survey of clinicians' practice in the symptomatic treatment of ALS. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2003;4(4):258-63. [PUBMED: 14753660]
Ganzini 1998 {published data only}
  • Ganzini L, Johnston WS, McFarland BH, Tolle SW, Lee MA. Attitudes of patients with amyotrophic lateral sclerosis and their care givers toward assisted suicide. New England Journal of Medicine 1998;339(14):967-73. [PUBMED: 9753713]
Ganzini 1999 {published data only}
Ganzini 2002a {published data only}
  • Ganzini L, Silveira MJ, Johnston WS. Predictors and correlates of interest in assisted suicide in the final month of life among ALS patients in Oregon and Washington. Journal of Pain and Symptom Management 2002;24(3):312-7. [PUBMED: 12458112]
Ganzini 2002b {published data only}
Hecht 2002 {published data only}
  • Hecht M, Hillemacher T, Gräsel E, Tigges S, Winterholler M, Heuss D, et al. Subjective experience and coping in ALS. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2002;3(4):225-31. [PUBMED: 12710513]
Jensen 2005 {published data only}
  • Jensen MP, Abresch RT, Carter GT, McDonald CM. Chronic pain in persons with neuromuscular disease. Archives of Physical Medicine and Rehabilitation 2005;86(6):1155-63. [PUBMED: 15954054]
Maessen 2010 {published data only}
  • Maessen M, Veldink JH, van den Berg LH, Schouten HJ, van der Wal G, Onwuteaka-Philipsen BD. Requests for euthanasia: origin of suffering in ALS, heart failure, and cancer patients. Journal of Neurology 2010;257(7):1192-8. [PUBMED: 20148336]
Mandler 2001 {published data only}
  • Mandler RN, Anderson FA Jr, Miller RG, Clawson L, Cudkowicz M, Del Bene M, ALS C.A.R.E. Study Group. The ALS Patient Care Database: insights into end-of-life care in ALS. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2001;2(4):203-8. [PUBMED: 11958732]
McClelland 2008 {published data only}
Neudert 2001 {published data only}
Newrick 1984 {published data only}
Newrick 1985 {published data only}
O'Brien 1992 {published data only}
Oliver 1996 {published data only}
Oliver 1998 {published data only}
Saunders 1981 {published data only}
  • Saunders C, Walsh TD, Smith M. Hospice care in motor neuron disease. In: Saunders C, Summers DH, Teller N editor(s). Hospice: The Living Idea. London: Edward Arnold, 1981. [0713143983]
Shibata 2003 {published data only}
  • Shibata M, Abe K, Jimbo A, Shimizu T, Mihara M, Sadahiro S, et al. Complex regional pain syndrome type I associated with amyotrophic lateral sclerosis. Clinical Journal of Pain 2003;19(1):69-70. [PUBMED: 12514459]
Tedman 1997 {published data only}
  • Tedman BM, Young CA, Williams IR. Assessment of depression in patients with motor neuron disease and other neurologically disabling illness. Journal of the Neurological Sciences 1997;152(Suppl 1):S75-9. [PUBMED: 9419059]
Trail 2003 {published data only}
  • Trail M, Nelson ND, Van JN, Appel SH, Lai EC. A study comparing patients with amyotrophic lateral sclerosis and their caregivers on measures of quality of life, depression, and their attitudes toward treatment options. Journal of the Neurological Sciences 2003;209(1-2):79-85. [PUBMED: 12686407]
Weber 2010 {published data only}
  • Weber M, Goldman B, Truniger S. Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: a randomised, double-blind crossover trial. Journal of Neurology, Neurosurgery and Psychiatry 2010;81(10):1135-40. [PUBMED: 20498181]
Winter 2010 {published data only}
  • Winter Y, Schepelmann K, Spottke AE, Claus D, Grothe C, Schröder R, et al. Health-related quality of life in ALS, myasthenia gravis and facioscapulohumeral muscular dystrophy. Journal of Neurology 2010 Apr 10 [Epub ahead of print];257(9):1473-81. [PUBMED: 20383521]
Wu 1998 {published data only}
  • Wu PY. The management of patients with advanced motor neuron disease. Zhonghua Yi Xue Za Zhi 1998;61(3):141-5. [PUBMED: 9556945]

Additional references

  1. References to studies excluded from this review
  2. Additional references
  3. References to other published versions of this review
Ashworth 2006
Baldinger 2012
Borasio 1997
Borasio 2001b
Brooks 2000
  • Brooks BR, Miller RG, Swash M, Munsat TL, World Federation of Neurology Research Group on Motor Neuron Diseases. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2000;1(5):293-9. [PUBMED: 11464847]
Brownell 1970
Clarke 2005
  • Clarke DM, McLeod JE, Smith GC, Trauer T, Kissane DW. A comparison of psychosocial and physical functioning in patients with motor neurone disease and metastatic cancer. Journal of Palliative Care 2005;21(3):173-9. [PUBMED: 16334972]
Coderre 2007
Drory 2001
  • Drory VE, Goltsman E, Reznik JG, Mosek A, Korczyn AD. The value of muscle exercise in patients with amyotrophic lateral sclerosis. Journal of the Neurological Sciences 2001;191(1-2):133-7. [PUBMED: 11677004]
El Tawil 2010
FDA 2006
  • US Food, Drug Administration. FDA orders unapproved quinine drugs from the market and cautions consumers about 'off-label' use of quinine to treat leg cramps. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108799.htm 2006.
FDA 2010
  • US Food, Drug Administration. FDA Drug Safety Communication: new risk management plan and patient Medication Guide for Qualaquin (quinine sulfate). http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm218202.htm 2010 (accessed 17 April 2013).
Gubbay 1985
  • Gubbay SS, Kahana E, Zilber N, Cooper G, Pintov S, Leibowitz Y. Amyotrophic lateral sclerosis. A study of its presentation and prognosis. Journal of Neurology 1985;232(5):295-300. [PUBMED: 4056836]
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. 2011. Available from www.cochrane-handbook.org.
Lawyer 1953
Lou 2003
Miller 1999
  • Miller RG, Rosenberg JA, Gelinas DF, Mitsumoto H, Newman D, Sufit R, et al. Practice parameter: the care of the patient with amyotrophic lateral sclerosis (an evidence based review): report of the Quality Standards Subcommittee of the American Academy of Neurology: ALS Practice Parameters Task Force. Neurology 1999;52(7):1311-23. [PUBMED: 10227612]
Miller 2001
  • Miller RG, Moore DH 2nd, Gelinas DF, Dronsky V, Mendoza M, Barohn RJ, et al. Western ALS Study Group. Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology 2001;56(7):843-8. [PUBMED: 11294919]
Pittenger 2008
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan) [Computer Program]. Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Sung 2003
  • Sung B, Lim G, Mao J. Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats. Journal of Neuroscience 2003;23(7):2899-910. [PUBMED: 12684477]
WHO 1990
  • Cancer pain relief and palliative care. Report of a WHO Expert Committee. World Health Organization Technical Report Series 1990; Vol. 804:1-75. [PUBMED: 1702248]
Worms 2001

References to other published versions of this review

  1. References to studies excluded from this review
  2. Additional references
  3. References to other published versions of this review
Brettschneider 2005
Brettschneider 2008