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Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery

  1. Daniel J Jones1,*,
  2. Frances Bunn2,
  3. Sophie V Bell-Syer3

Editorial Group: Cochrane Wounds Group

Published Online: 9 MAR 2014

Assessed as up-to-date: 5 DEC 2013

DOI: 10.1002/14651858.CD005360.pub4


How to Cite

Jones DJ, Bunn F, Bell-Syer SV. Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery. Cochrane Database of Systematic Reviews 2014, Issue 3. Art. No.: CD005360. DOI: 10.1002/14651858.CD005360.pub4.

Author Information

  1. 1

    University of York, Department of Health Sciences, York, UK

  2. 2

    University of Hertfordshire, Centre for Research in Primary and Community Care, Hatfield, Hertfordshire, UK

  3. 3

    Royal United Hospital, Bath, UK

*Daniel J Jones, Department of Health Sciences, University of York, Seebohm Rowntree Building, York, YO10 5DD, UK. ugm4djj@gmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 9 MAR 2014

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Amland 1995 {published data only}
  • Amland PF, Andenaes K, Samdal F, Linaas E, Sandsmark M, Abeyholm F, et al. A prospective double-blind, placebo-controlled trial of a single dose of azithromycin on postoperative wound infections in plastic surgery. Plastic and Reconstructive Surgery 1995;96(6):1378-83.
Bold 1998 {published data only}
  • Bold RJ, Mansfield PF, Berger DH, Pollock RE, Sinletary SE, Ames FC, et al. Prospective randomised, double-blind study of prophylactic antibiotics in axillary lymph node dissection. American Journal of Surgery 1998;176(3):239-43.
Cabaluna 2012 {published data only}
  • Cabaluna ND, Galicia RM, Yray MDS. A randomized, double-blinded placebo-controlled clinical trial of the routine use of preoperative antibiotic prophylaxis in modified radical mastectomy. World Journal of Surgery 2012;37:59-66.
Chow 2000 {published data only}
  • Chow LW, Yuen KY, Woo PC, Wei W. Clarithromycin attenuates mastectomy-induced acute inflammatory response. Clinical and Diagnostic Laboratory Immunology 2000;7(6):925-31.
Gulluoglu 2013 {published data only}
  • Gulluoglu B, Guler S, Ugurlu U. Efficacy of prophylactic antibiotic administration for breast cancer surgery in overweight or obese patients. Annals of Surgery 2013;257(1):37-43.
Gupta 2000 {published data only}
  • Gupta R, Sinnett D, Carpenter R, Preece PE, Royle GT. Antibiotic prophylaxis for post-operative wound infection in clean elective breast surgery. European Journal of Surgical Oncology 2000;26(4):363-6.
Hall 2006 {published data only}
Paajanen 2009 {published data only}
  • Paajanen H, Hermunen H. Does preoperative core needle biopsy increase surgical site infections in breast cancer surgery? Randomized study of antibiotic prophylaxis. Surgical Infections 2009;10(4):317-21.
Platt 1990 {published data only}
  • Platt R, Zaleznik DF, Hopkins CC, Dellinger EP, Karchmer AW, Bryan CS, et al. Perioperative antibiotic prophylaxis for hernioplasty and breast surgery. New England Journal of Medicine 1990;322(3):153-60.
Wagman 1990 {published data only}
  • Wagman LD, Tegtmeier B, Beatty JD, Kloth DD, Kokal WA, Riihimaki DU, et al. A prospective, randomised double-blind study of the use of antibiotics at the time of mastectomy. Surgery, Gynecology and Obstetrics 1990;170(1):12-6.
Yetim 2010 {published data only}
  • Yetim I, Ozkan OV, Dervisoglu A, Erzurumlu K, Canbolant E. Effect of local gentamycin application on healing and wound infection in patients with modified radical mastectomy: a prospective randomised study. Journal of International Medical Research 2010;38(4):1442-7.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Baker 2000 {published data only}
  • Baker KA. Antibiotic prophylaxis for selected implants and devices. CDA Journal 2000;28(35):620-6.
Baker 2005 {published and unpublished data}
  • Baker E, Kumar S, Whetter D, Melling A, Leaper D. Does warming effect wound healing profiles following breast surgery?. European wound management association conference; 2005, 15-17 September; Stuttgart, Germany 2005;2:68.
Bertin 1998 {published data only}
Boyd 1981 {published data only}
D'Amico 2001 {published data only}
  • D'Amico DF, Parimbelli P, Ruffolo C. Antibiotic prophylaxis in clean surgery: breast surgery and hernia repair. Journal of Chemotherapy 2001;13(1):108-11.
Erfle 2002 {published data only}
  • Erfle V, Schoen A, Marquart KH, Pawlita M. [HGF-Strategiefond 'Infektabwehr und Krebspaevention'. Impfstoff gegen krebs-Infektionsabwehr und Krebspraevention. Abschlussbericht. GSF- Forschungszentrum fuer Umwelt und Gesundhiet Neuherberg GmbH Oberschleissheim (DE)]. SIGLE. 2002.
Esposito 2006 {published data only}
  • Esposito S, Leone S, Noviello S, Ianniello F, Marvaso A, Cuniato V, et al. Antibiotic prophylaxis in hernia repair and breast surgery: a prospective randomised study comparing piperacillin/tazobactam versus placebo. Journal of Chemotherapy 2006;18(3):278-84.
Exener 1992 {published data only}
  • Exner K, Lang E, Borsche A, Lemperle G. Efficacy, tolerability and pharmokinetics of teicoplanin in patients undergoing breast surgery. European Journal of Surgery 1992;Suppl 567:9-12.
Franchelli 1994 {published data only}
  • Franchelli S, Leone MS, Vigna E, Rapsosio E, Cafierio F, Constantini M, et al. Perioperative teicoplanin prophylaxis in patients undergoing breast reconstruction with the abdominal wall. A case control study. Minerva Chirurgica 1994;49(1):59-60.
Hall 2000 {published data only}
Kumar 2005 {published and unpublished data}
  • Kumar S, Melling A, Wong PF, Whetter D, Leaper DJ. Wound infection prophylaxis in breast surgery: a randomised controlled trial comparing the efficacy of antibiotics and perioperative wound warming. British Journal of Surgery 2005;92(1):67.
LeRoy 1991 {published data only}
Lewis 1995 {published data only}
Melling 2005 {published and unpublished data}
  • Melling A, Kumar S, Whetter D, Baker L, Leaper D. A comparison of warming with antibiotics or both on the rate of surgical site infection after breast surgery. European wound management association conference; 2005, 15-17 September; Stuttgart, Germany 2005;Thursday 14:00-15:30; V25-3:67.
Melling 2006 {published and unpublished data}
  • Melling A, Kumar S, Whetter D, Baker E, Leaper D. Local warming may enhance the effect of prophylactic antibiotics in breast surgery. 16th conference of the european wound management association; 2006, 18-20 May; Prague, Czech Republic. 2006:88, Abstract no.109.
Morimoto 1998 {published data only}
Nicholas 2007 {published data only}
  • Nicholas P, Yazdan Y, Marie Pierre C, Sylvia G, Jean Charles N, Daniele L, et al. Prevention of surgical site infection after breast cancer surgery by targeted prophylaxis antibiotic in patients at high risk of surgical site infection. Journal of Surgical Oncology 2007;96(2):124-9.
Pennel 2004 {published data only}
  • Pennel N, Fournier C, Giard S, Lefebvres D. A prospective evaluation of antibiotic prophylaxis for breast surgery following previous chemotherapy. Bulletin du Cancer 2004;91(5):445-8.
Platt 1992 {published data only}
  • Platt R, Zucker JR, Zaleznik DF, Hopkins CC, Dellinger EP, Karchmer AW, et al. Prophylaxis against wound infection following hernioplasty or breast surgery. Journal of Infectious Diseases 1992;166(3):556-60.
Platt 1993 {published data only}
  • Platt R, Zucker JR, Zaleznik DF, Hopkins CC, Dellinger EP, Karchmer AW, et al. Perioperative antibiotic prophylaxis and wound infection following breast surgery. Journal of Antimicrobial Chemotherapy 1993;31(Suppl B):43-8.
Sanguinetti 2009 {published data only}
  • Sanguinetti A, Rosato L, Cirocchi R, Barberini F, Pezzolla A, Cavallaro G, et al. Antibiotic prophylaxis in breast surgery. Preliminary results of a multicenter randomised study on 1400 cases [Antibiotico profilassi in Chirurgia Senologica Risultati preliminari di uno studio multicentrico randomizzato su 1400 casi trattati]. Annali Italiani di Chirurgia 2009;80(4):275-9.
Sasaki 1988 {published data only}
  • Sasaki F, Takada N, Hata Y, Kyunoh K, Uchino J. A study on the transfer of cefbuperazone into postoperative exudate in patients subjected to cancer mastectomy or thyroidectomy. Japanese Journal of Antibiotics 1988;466:114-20.
Serletti 1994 {published data only}
Shamilov 1991 {published data only}
  • Shamilov AK, Smolianskaia AZ. The antibiotic prophylaxis of postoperative complications in breast cancer patients. Antibiotiki i Khimioterapiia 1991;36(6):43-4.
Spicher 2003 {published data only}
  • Spicher I, Beer GM, Minder J, Ruef Ch, Szucs T, Meyer VE. Perioperative antibiotic prophylaxis at the clinic of reconstructive surgery of the university hospital Zurich [Zur umsetzung einer perioperativen antibiotikapropylaxe an der klinik fur wiederstellungschirugie des universitatsspitals Zurich]. Swiss Surgery 2003;9(1):9-14.
Sultan 1989 {published data only}
  • Sultan S, Ahmed R, Mufti T, Mohammad G, Nawaz M. Use of prophylactic antibiotics in clean surgical cases - a prospective trial of various regimens. Journal of Pakistan Medical Association 1989;39(1):9-12.
Thomas 1999 {published data only}
  • Thomas R, Alivino P, Cortino GR, Accardo R, Rinaldo M, Pizzorusso M, et al. Long acting versus short acting cephalosporins for preoperative prophylaxis in breast surgery: a randomised double-blind trial involving 1,766 patients. Chemotherapy 1999;45(3):217-23.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bray 2004
Coello 1993
Donegan 1995
  • Donegan WL, Spratt JS. Cancer of the Breast. Missouri: Elsevier Science, 1995.
Gillespie 2010
Gruendemann 2001
Haley 1985
  • Haley RW, Culver DH, Mead Morgan W, White JW, Emori GT, Hooton TM. Identifying patients at high risk of surgical wound infection. American Journal of Epidemiology 1985;121(2):206-15.
Harris 2004
  • Harris JR (Ed). Diseases of the Breast. Philadelphia: Lippincott Williams & Wilkins, 2004.
Higgins 2003
Higgins 2011
  • Higgins JPT, Altman DG, on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group (Editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Lefebvre 2000
  • Lefebvre D, Penel N, Deberles MF, Fournier C. Incidence and surgical wound infection risk factors in breast cancer surgery. Presse Medicale 2000;29(35):1927-32.
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville J, on behalf of the Cochrane Information Retrieval Methods Group. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Majoribanks 2004
  • Majoribanks J, Callis K, Jordan V. Antibiotic prophylaxis for elective hysterectomy. Cochrane Database of Systematic Reviews 2004, Issue 1. [DOI: 10.1002/14651858.CD004637]
Mangram 1999
  • Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for the prevention of surgical site infection. Infection Control and Hospital Epidemiology 1999;20(4):247-78.
Mitchell 1999
Morris 1988
  • Morris DM, Robinson K. The effect of method of biopsy and timing of mastectomy on the development of post mastectomy non sociocomial wound infection. Journal of the Louisiana State Medical Society 1988;140(37):363-6.
NICE 2002
  • National Institute for Clinical Excellence. Improving outcomes in breast cancer: Manual update. NICE 2002:http://www.mccn.nhs.uk/userfiles/documents/Improving_outcomes_breastcancer_manual.pdf.
PHLS 2000
  • Public Health Laboratory Service (PHLS). Antimicrobial resistance in 2000. England and Wales. http://www.hpa.org.uk/web/HPAwebFile/HPAweb_C/1194947317696 2000.
Pisani 1999
Pittet 2005
  • Pittet B, Montandon D, Pittet D. Infection in breast implants. Lancet Infectious Diseases 2005;5(2):94-106.
Ritter 1988
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Sajid 2012
Sanchez-Manuel 2007
Schulz 1995
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273(5):408-12.
Sheridan 1994
  • Sheridan RL, Tompkins RG, Burke JF. Prophylactic antibiotics and their role in the prevention of surgical wound infection. Advances in Surgery. Year Book Medical, 1994:43-65.
SIGN 2008a
  • Scottish Intercollegiate Guidelines Network (SIGN). Benefits and risks of antibiotic prophylaxis. Antibiotic prophylaxis in surgery: a national clinical guideline. Available at http://www.sign.ac.uk/pdf/sign104.pdf. Scottish Intercollegiate Guidelines Network, 2008:9-12.
SIGN 2008b
  • Scottish Intercollegiate Guidelines Network (SIGN). Search filters. http://www.sign.ac.uk/methodology/filters.html#random (accessed 14 August 2008).
Spauwen 2000
  • Spauwen PHM, Wobbes T, Van Der Sluis RF. Immediate breast reconstruction: results and satisfaction. European Journal of Plastic Surgery 2000;23:211-3.
Tejirian 2006
  • Tejirian T, DiFronzo A, Haigh PI. Antibiotic prophylaxis for preventing wound infection after breast surgery: a systematic review and meta analysis. Journal of the American College of Surgeons 2006;203(5):729-34.
Tran 2003
  • Tran CL, Langer S, Brodwick-Villa G, DiFronzo LA. Does re-operation predispose to post-operative wound infection in women undergoing operation for breast cancer?. American Surgery 2003;69(10):852-6.
Vazquez-Aragon 2003
  • Vazquez-Aragon P, Lizan-Garcia M, Cascales-Sanchez P, Villar-Canovas MT, Garcia-Olmo D. Nosocomial infection and related risk factors in a general surgery setting: a prospective study. Journal of Infection 2003;46(1):17-22.
Wilson 1986
  • Wilson APR, Treasure T, Sturridge MF, Gruneberg RN. A scoring method (ASEPSIS) for postoperative wound infections for use in clinical trials of antibiotic prophylaxis. Lancet 1986;1(8476):311-3.
Witt 2003
  • Witt A, Yavuz D, Walchetseder C, Strohmer H, Kubista E. Preoperative core needle biopsy as an independent risk factor for wound infection after breast surgery. Obstetrics and Gynecology 2003;101(4):745-50.